Jefferies Financial Group’s Structure Therapeutics GPCR Stock Holding History

Jefferies Financial Group’s Portfolio GPCR Stock Details GPCR Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$2.18M	Sell	40,625 -21,967	-35%	-$972K	0.01%	664
2026 Q1	$3.02M	Sell	62,592 -40,401	-39%	-$2.76M	0.02%	474
2025 Q4	$7.16M	Sell	102,993 -67,352	-40%	-$2.75M	0.04%	407
2025 Q3	$4.77M	Buy	+170,345	New	+$3.39M	0.02%	383
2025 Q1	–	Sell	-2,000	Closed	-$54.2K	–	1767
2024 Q4	$54.2K	Sell	2,000 -5,000	-71%	-$177K	﹤0.01%	1495
2024 Q3	$307K	Buy	+7,000	New	+$271K	﹤0.01%	1109
2024 Q2	–	Sell	-2,000	Closed	-$85.7K	–	1576
2024 Q1	$85.7K	Buy	+2,000	New	+$84.3K	﹤0.01%	1451

Other funds holding GPCR

Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return

Wellington Management Group Boston, Massachusetts $580B AUM 38.23% 1-Year Est. Return

ACA

Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return

Jupiter Topco New York $245B AUM

DTC

Deep Track Capital Greenwich, Connecticut $6.87B AUM 205.24% 1-Year Est. Return

BVF Inc San Francisco, California $3.91B AUM 304.52% 1-Year Est. Return

Morgan Stanley New York $1.89T AUM 35.08% 1-Year Est. Return

OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return

Principal Financial Group Des Moines, Iowa $204B AUM 27.99% 1-Year Est. Return

American Century Companies Kansas City, Missouri $226B AUM 44.75% 1-Year Est. Return

Jefferies Financial Group's GPCR Position: Q2 2026 in Review

Jefferies Financial Group reduced its Structure Therapeutics (GPCR) stake by 35% in Q2 2026, selling an estimated $972K and leaving 40,625 shares worth $2.18M. The position accounts for 0.01% of the portfolio, ranked #664.

Jefferies Financial Group first reported a position in GPCR in Q1 2024 and has held it in 7 quarters since. The position peaked at $7.16M in Q4 2025. 191 funds tracked by Wall St. Rank hold GPCR as of Q2 2026.

Jefferies Financial Group held 40,625 shares of Structure Therapeutics worth $2.18M as of Q2 2026.
Jefferies Financial Group sold 21,967 Structure Therapeutics shares in Q2 2026, an estimated $972K.
Structure Therapeutics made up 0.01% of Jefferies Financial Group's portfolio in Q2 2026, its #664 holding.
Jefferies Financial Group first reported a position in Structure Therapeutics in Q1 2024 and has held it in 7 quarters since.
Jefferies Financial Group's Structure Therapeutics position peaked at $7.16M in Q4 2025.
191 funds tracked by Wall St. Rank held Structure Therapeutics as of Q2 2026.

Based on Jefferies Financial Group's 13F filing for Q2 2026, filed 17 Aug 2026.