Jefferies Financial Group’s Structure Therapeutics GPCR Stock Holding History

Jefferies Financial Group’s Portfolio GPCR Stock Details GPCR Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q1	–	Sell	-27,100	Closed	-$735K	–	1766
2024 Q4	$735K	Hold	27,100	–	–	﹤0.01%	992
2024 Q3	$1.19M	Buy	+27,100	New	+$1.05M	0.01%	743
2024 Q2	–	Sell	-46,900	Closed	-$2.01M	–	1575
2024 Q1	$2.01M	Buy	+46,900	New	+$1.98M	0.02%	594

Other funds holding GPCR

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return

ACA

Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return

DTC

Deep Track Capital Greenwich, Connecticut $6.12B AUM 144% 1-Year Est. Return

BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return

Principal Financial Group Des Moines, Iowa $187B AUM 18.48% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return

Jefferies Financial Group's GPCR Position: Q1 2026 in Review

Jefferies Financial Group reduced its Structure Therapeutics (GPCR) stake by 39% in Q1 2026, selling an estimated $2.76M and leaving 62,592 shares worth $3.02M. The position accounts for 0.02% of the portfolio, ranked #474.

Jefferies Financial Group first reported a position in GPCR in Q1 2024 and has held it in 6 quarters since. The position peaked at $7.16M in Q4 2025. 196 funds tracked by Wall St. Rank hold GPCR as of Q1 2026.

Jefferies Financial Group held 62,592 shares of Structure Therapeutics worth $3.02M as of Q1 2026.
Jefferies Financial Group sold 40,401 Structure Therapeutics shares in Q1 2026, an estimated $2.76M.
Structure Therapeutics made up 0.02% of Jefferies Financial Group's portfolio in Q1 2026, its #474 holding.
Jefferies Financial Group first reported a position in Structure Therapeutics in Q1 2024 and has held it in 6 quarters since.
Jefferies Financial Group's Structure Therapeutics position peaked at $7.16M in Q4 2025.
196 funds tracked by Wall St. Rank held Structure Therapeutics as of Q1 2026.

Based on Jefferies Financial Group's 13F filing for Q1 2026, filed 8 May 2026.