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Amicus Therapeutics
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Overview Fund Activity

268 hedge funds and large institutions have $1.83B invested in Amicus Therapeutics in 2025 Q2 according to their latest regulatory filings, with 35 funds opening new positions, 118 increasing their positions, 81 reducing their positions, and 47 closing their positions.

Holders
268
Holders Change
-13
Holders Change %
-4.63%
% of All Funds
3.6%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
35
Increased
118
Reduced
81
Closed
47
Calls
$2.41M
Puts
$1.56M
Net Calls
+$846K
Net Calls Change
+$2.68M

Top Buyers

1
VPC
1
Vestal Point Capital
New York
$68.2M
2
D.E. Shaw & Co
2
D.E. Shaw & Co
New York
$36.5M
3
Millennium Management
3
Millennium Management
New York
$42.5M
4
Assenagon Asset Management
4
Assenagon Asset Management
Luxembourg
$20.2M
5
Qube Research & Technologies (QRT)
5
Qube Research & Technologies (QRT)
United Kingdom
$19.9M

Top Sellers

1
PA
1
Perceptive Advisors
New York
$42.5M
2
RG
2
Redmile Group
California
$6.81M
3
American Century Companies
3
American Century Companies
Missouri
$0
4
NHAS
4
Novo Holdings A/S
Denmark
$0
5
JPMorgan Chase & Co
5
JPMorgan Chase & Co
New York
$12.7M
Name Holding Trade Value Shares
Change 		Shares
Change %
DS
126
DRW Securities
Illinois
$535K +$535K +93,387 New
CIM
127
CIM Investment Management
Pennsylvania
$511K +$256K +33,681 +101%
NRD
128
Nebula Research & Development
New York
$510K +$161K +28,075 +46%
State Board of Administration of Florida Retirement System
129
State Board of Administration of Florida Retirement System
Florida
$505K – – –
PA
130
Profund Advisors
Maryland
$502K +$183K +31,997 +57%
Handelsbanken Fonder
131
Handelsbanken Fonder
Sweden
$501K – – –
Canada Life
132
Canada Life
Manitoba, Canada
$480K +$13K +2,263 +3%
DT
133
Diversified Trust
Tennessee
$479K – – –
A
134
AlphaQuest
New York
$465K +$251K +43,765 +117%
Acadian Asset Management
135
Acadian Asset Management
Massachusetts
$422K +$422K +73,915 New
VIA
136
Virtus Investment Advisers
Connecticut
$413K +$210K +36,655 +104%
ASRS
137
Arizona State Retirement System
Arizona
$401K +$33K +5,765 +9%
ProShare Advisors
138
ProShare Advisors
Maryland
$393K -$50.3K -8,783 -11%
II
139
Inspire Investing
Idaho
$391K +$146K +25,479 +60%
PFSRSONJ
140
Police & Firemen's Retirement System of New Jersey
New Jersey
$380K +$21.1K +3,688 +6%
HSBC Holdings
141
HSBC Holdings
United Kingdom
$377K +$84.5K +14,588 +29%
Teacher Retirement System of Texas
142
Teacher Retirement System of Texas
Texas
$370K +$24.7K +4,303 +7%
Envestnet Asset Management
143
Envestnet Asset Management
Illinois
$368K -$701K -122,299 -66%
CUAMC
144
China Universal Asset Management Company
China
$354K +$1.26K +220 +0.4%
Stifel Financial
145
Stifel Financial
Missouri
$353K +$159K +27,811 +82%
Zurich Cantonal Bank
146
Zurich Cantonal Bank
Switzerland
$345K – – –
GCP
147
GSA Capital Partners
United Kingdom
$328K -$13.4K -2,338 -4%
TI
148
Tidal Investments
Wisconsin
$320K +$320K +55,867 New
Thrivent Financial for Lutherans
149
Thrivent Financial for Lutherans
Minnesota
$318K – – –
PD
150
Point72 (DIFC)
United Arab Emirates
$316K +$35K +6,107 +12%
4 5
6
7 8