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Amicus Therapeutics
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Overview Fund Activity

265 hedge funds and large institutions have $1.82B invested in Amicus Therapeutics in 2025 Q2 according to their latest regulatory filings, with 35 funds opening new positions, 117 increasing their positions, 79 reducing their positions, and 47 closing their positions.

Holders
265
Holders Change
-16
Holders Change %
-5.69%
% of All Funds
3.56%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
35
Increased
117
Reduced
79
Closed
47
Calls
$2.34M
Puts
$1.56M
Net Calls
+$782K
Net Calls Change
+$2.62M

Top Buyers

1
VPC
1
Vestal Point Capital
New York
$68.2M
2
D.E. Shaw & Co
2
D.E. Shaw & Co
New York
$36.5M
3
Millennium Management
3
Millennium Management
New York
$42.5M
4
Norges Bank
4
Norges Bank
Norway
$18.5M
5
Assenagon Asset Management
5
Assenagon Asset Management
Luxembourg
$20.2M

Top Sellers

1
PA
1
Perceptive Advisors
New York
$42.5M
2
RG
2
Redmile Group
California
$6.81M
3
American Century Companies
3
American Century Companies
Missouri
$0
4
NHAS
4
Novo Holdings A/S
Denmark
$0
5
JPMorgan Chase & Co
5
JPMorgan Chase & Co
New York
$12.7M
Name Market Value Shares Shares
Change 		Shares
Change %
Vanguard Group
1
Vanguard Group
Pennsylvania
$169M 29,407,588 +356,967 +1%
Wellington Management Group
2
Wellington Management Group
Massachusetts
$167M 29,123,962 -76,655 -0.3%
BlackRock
3
BlackRock
New York
$158M 27,532,209 -291,563 -1%
ACA
4
Avoro Capital Advisors
New York
$103M 18,000,000 -2,500,000 -12%
William Blair Investment Management
5
William Blair Investment Management
Illinois
$83.9M 14,642,157 -136,494 -0.9%
VPC
6
Vestal Point Capital
New York
$68.2M 11,900,000 +7,625,000 +178%
State Street
7
State Street
Massachusetts
$66.3M 11,568,097 +2,049,078 +22%
Macquarie Group
8
Macquarie Group
Australia
$44.2M 7,722,318 +907,236 +13%
Millennium Management
9
Millennium Management
New York
$42.5M 7,421,640 +4,062,251 +121%
PA
10
Perceptive Advisors
New York
$42.5M 7,412,830 -14,051,697 -65%
Bank of America
11
Bank of America
North Carolina
$39.2M 6,847,275 +1,247,596 +22%
Geode Capital Management
12
Geode Capital Management
Massachusetts
$38.4M 6,706,489 -57,278 -0.8%
D.E. Shaw & Co
13
D.E. Shaw & Co
New York
$36.5M 6,362,250 +4,071,968 +178%
Citadel Advisors
14
Citadel Advisors
Florida
$34.2M 5,974,643 -1,864,900 -24%
PAI
15
Palo Alto Investors
California
$32.1M 5,610,513 -1,734,489 -24%
Goldman Sachs
16
Goldman Sachs
New York
$24.9M 4,342,755 +1,639,178 +61%
Morgan Stanley
17
Morgan Stanley
New York
$24.6M 4,292,362 +1,864,228 +77%
Pictet Asset Management
18
Pictet Asset Management
Switzerland
$22.8M 3,907,569 +2,279,356 +140%
Massachusetts Financial Services
19
Massachusetts Financial Services
Massachusetts
$21.4M 3,726,468 +450,097 +14%
NL
20
Nuveen LLC
North Carolina
$20.8M 3,631,801 +109,584 +3%
Assenagon Asset Management
21
Assenagon Asset Management
Luxembourg
$20.2M 3,533,854 +3,057,072 +641%
PM
22
Prosight Management
Texas
$19.9M 3,480,044 +2,100,661 +152%
Qube Research & Technologies (QRT)
23
Qube Research & Technologies (QRT)
United Kingdom
$19.9M 3,466,911 +2,396,410 +224%
Point72 Asset Management
24
Point72 Asset Management
Connecticut
$18.8M 3,279,047 +293,939 +10%
Norges Bank
25
Norges Bank
Norway
$18.5M 3,235,538 +3,235,538 New
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