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Amicus Therapeutics
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Overview Fund Activity

265 hedge funds and large institutions have $1.82B invested in Amicus Therapeutics in 2025 Q2 according to their latest regulatory filings, with 35 funds opening new positions, 117 increasing their positions, 79 reducing their positions, and 47 closing their positions.

Holders
265
Holders Change
-16
Holders Change %
-5.69%
% of All Funds
3.56%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
35
Increased
117
Reduced
79
Closed
47
Calls
$2.34M
Puts
$1.56M
Net Calls
+$782K
Net Calls Change
+$2.62M

Top Buyers

1
VPC
1
Vestal Point Capital
New York
$68.2M
2
D.E. Shaw & Co
2
D.E. Shaw & Co
New York
$36.5M
3
Millennium Management
3
Millennium Management
New York
$42.5M
4
Norges Bank
4
Norges Bank
Norway
$18.5M
5
Assenagon Asset Management
5
Assenagon Asset Management
Luxembourg
$20.2M

Top Sellers

1
PA
1
Perceptive Advisors
New York
$42.5M
2
RG
2
Redmile Group
California
$6.81M
3
American Century Companies
3
American Century Companies
Missouri
$0
4
NHAS
4
Novo Holdings A/S
Denmark
$0
5
JPMorgan Chase & Co
5
JPMorgan Chase & Co
New York
$12.7M
Name Market Value Shares Shares
Change 		Shares
Change %
California State Teachers Retirement System (CalSTRS)
101
California State Teachers Retirement System (CalSTRS)
California
$1.2M 209,131 +566 +0.3%
MIM
102
MetLife Investment Management
New Jersey
$992K 173,078 -979 -0.6%
AA
103
ALPS Advisors
Colorado
$952K 166,075 -56,173 -25%
HF
104
HRT Financial
New York
$927K 161,918 -103,776 -39%
Wells Fargo
105
Wells Fargo
California
$926K 161,579 -3,139 -2%
HT
106
Headlands Technologies
Illinois
$914K 159,522 +103,492 +185%
Tudor Investment Corp
107
Tudor Investment Corp
Connecticut
$914K 159,497 +88,206 +124%
Manulife (Manufacturers Life Insurance)
108
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$870K 151,860 -10,763 -7%
WCM
109
Wedge Capital Management
North Carolina
$829K 144,710 +932 +0.6%
Mackenzie Financial
110
Mackenzie Financial
Ontario, Canada
$798K 139,207 +96,602 +227%
GAM
111
Gotham Asset Management
New York
$782K 136,536 +82,546 +153%
First Trust Advisors
112
First Trust Advisors
Illinois
$771K 134,539 +4,537 +3%
IIM
113
INTECH Investment Management
Florida
$705K 123,015 -47,907 -28%
EAM
114
Erste Asset Management
Austria
$693K 116,850 – –
SAM
115
Sectoral Asset Management
Quebec, Canada
$685K 119,585 +12,000 +11%
Russell Investments Group
116
Russell Investments Group
United Kingdom
$677K 118,235 -24,334 -17%
TRSOTSOK
117
Teachers Retirement System of the State of Kentucky
Kentucky
$645K 112,499 +29,916 +36%
AQR Capital Management
118
AQR Capital Management
Connecticut
$639K 111,592 +69,138 +163%
Victory Capital Management
119
Victory Capital Management
Texas
$593K 103,481 -153,607 -60%
GC
120
Guggenheim Capital
Illinois
$576K 100,490 +15,353 +18%
Pathstone Holdings
121
Pathstone Holdings
New Jersey
$574K 100,110 -108 -0.1%
Ensign Peak Advisors
122
Ensign Peak Advisors
Utah
$566K 98,806 – –
BHCM
123
Brevan Howard Capital Management
Jersey
$560K 97,688 +97,688 New
DS
124
DRW Securities
Illinois
$535K 93,387 +93,387 New
CIM
125
CIM Investment Management
Pennsylvania
$511K 67,113 +33,681 +101%
3 4
5
6 7