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Two Sigma Securities’s State Street SPDR S&P Biotech ETF XBI Stock Holding History

Two Sigma Securities’s Portfolio XBI Stock Details XBI Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2024
Q4 		– Sell
-17,500
Closed -$1.73M – 3357
2024
Q3 		$1.73M Sell
17,500
-5,300
-23% -$521K 0.03% 609
2024
Q2 		$2.11M Sell
22,800
-500
-2% -$44.8K 0.03% 687
2024
Q1 		$2.21M Sell
23,300
-31,800
-58% -$2.95M 0.02% 711
2023
Q4 		$4.92M Sell
55,100
-16,600
-23% -$1.23M 0.05% 366
2023
Q3 		$5.24M Buy
71,700
+53,400
+292% +$4.27M 0.06% 354
2023
Q2 		$1.52M Sell
18,300
-1,600
-8% -$134K 0.02% 734
2023
Q1 		$1.52M Sell
19,900
-44,400
-69% -$3.68M 0.03% 641
2022
Q4 		$5.34M Buy
64,300
+42,000
+188% +$3.4M 0.16% 137
2022
Q3 		$1.77M Buy
22,300
+16,500
+284% +$1.39M 0.05% 402
2022
Q2 		$431K Buy
5,800
+2,900
+100% +$218K 0.02% 1015
2022
Q1 		$261K Sell
2,900
-3,800
-57% -$351K 0.01% 1520
2021
Q4 		$750K Sell
6,700
-39,000
-85% -$4.7M 0.03% 360
2021
Q3 		$5.75M Buy
45,700
+13,900
+44% +$1.79M 0.17% 96
2021
Q2 		$4.31M Buy
+31,800
New +$4.18M 0.13% 103
2021
Q1 		– Sell
-24,000
Closed -$3.38M – 1831
2020
Q4 		$3.38M Buy
24,000
+8,700
+57% +$1.11M 0.08% 156
2020
Q3 		$1.71M Sell
15,300
-28,800
-65% -$3.23M 0.03% 237
2020
Q2 		$4.94M Buy
44,100
+12,000
+37% +$1.18M 0.11% 98
2020
Q1 		$2.49M Sell
32,100
-185,500
-85% -$16.4M 0.06% 215
2019
Q4 		$20.7M Buy
217,600
+139,300
+178% +$12M 0.14% 95
2019
Q3 		$5.97M Sell
78,300
-31,900
-29% -$2.65M 0.05% 276
2019
Q2 		$9.67M Buy
110,200
+107,800
+4,492% +$9.19M 0.1% 115
2019
Q1 		$217K Sell
2,400
-32,800
-93% -$2.79M ﹤0.01% 1426
2018
Q4 		$2.53M Sell
35,200
-95,100
-73% -$7.66M 0.03% 292
2018
Q3 		$12.5M Sell
130,300
-189,100
-59% -$18.3M 0.08% 168
2018
Q2 		$30.4M Buy
319,400
+69,100
+28% +$6.35M 0.15% 95
2018
Q1 		$22M Buy
250,300
+181,400
+263% +$16.6M 0.12% 139
2017
Q4 		$5.85M Buy
+68,900
New +$5.77M 0.16% 102

Other funds holding XBI

Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
BNP Paribas Financial Markets
BNP Paribas Financial Markets Paris, France $206B AUM 31.61% 1-Year Est. Return
Bank of America
Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund Toronto, Ontario, Canada $62.2B AUM 31.35% 1-Year Est. Return
Citigroup
Citigroup New York $235B AUM 32.99% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return
Wells Fargo
Wells Fargo San Francisco, California $530B AUM 22.01% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Two Sigma Securities's XBI Position: Q4 2025 in Review

Two Sigma Securities sold out of State Street SPDR S&P Biotech ETF (XBI) in Q4 2025, closing a stake of 4,935 shares — an estimated $494K sold.

Two Sigma Securities first reported a position in XBI in Q1 2015 and held it in 26 quarters. The position peaked at $10.2M in Q1 2017. 813 funds tracked by Wall St. Rank hold XBI as of Q4 2025.

  • Two Sigma Securities reported no remaining State Street SPDR S&P Biotech ETF position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Securities sold 4,935 State Street SPDR S&P Biotech ETF shares in Q4 2025, an estimated $494K.
  • Two Sigma Securities first reported a position in State Street SPDR S&P Biotech ETF in Q1 2015 and held it in 26 quarters.
  • Two Sigma Securities's State Street SPDR S&P Biotech ETF position peaked at $10.2M in Q1 2017.
  • 813 funds tracked by Wall St. Rank held State Street SPDR S&P Biotech ETF as of Q4 2025.

Based on Two Sigma Securities's 13F filing for Q4 2025, filed 17 Feb 2026.