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Two Sigma Securities’s State Street SPDR S&P Biotech ETF XBI Stock Holding History

Two Sigma Securities’s Portfolio XBI Stock Details XBI Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2024
Q4 		– Sell
-10,700
Closed -$1.06M – 3356
2024
Q3 		$1.06M Sell
10,700
-8,100
-43% -$796K 0.02% 858
2024
Q2 		$1.74M Sell
18,800
-27,000
-59% -$2.42M 0.02% 778
2024
Q1 		$4.35M Buy
45,800
+1,300
+3% +$121K 0.04% 448
2023
Q4 		$3.97M Buy
44,500
+32,600
+274% +$2.42M 0.04% 433
2023
Q3 		$869K Sell
11,900
-38,300
-76% -$3.06M 0.01% 1141
2023
Q2 		$4.18M Buy
50,200
+37,800
+305% +$3.16M 0.06% 339
2023
Q1 		$945K Sell
12,400
-88,800
-88% -$7.37M 0.02% 863
2022
Q4 		$8.4M Buy
101,200
+73,700
+268% +$5.97M 0.25% 67
2022
Q3 		$2.18M Buy
27,500
+19,500
+244% +$1.64M 0.07% 333
2022
Q2 		$594K Buy
8,000
+600
+8% +$45K 0.02% 799
2022
Q1 		$665K Sell
7,400
-600
-8% -$55.4K 0.02% 831
2021
Q4 		$896K Sell
8,000
-51,800
-87% -$6.25M 0.04% 298
2021
Q3 		$7.52M Buy
59,800
+21,300
+55% +$2.74M 0.22% 63
2021
Q2 		$5.21M Buy
+38,500
New +$5.06M 0.16% 85
2021
Q1 		– Sell
-11,500
Closed -$1.62M – 1829
2020
Q4 		$1.62M Buy
11,500
+100
+0.9% +$12.8K 0.04% 289
2020
Q3 		$1.27M Sell
11,400
-17,600
-61% -$1.97M 0.03% 297
2020
Q2 		$3.25M Buy
29,000
+13,300
+85% +$1.31M 0.07% 151
2020
Q1 		$1.22M Sell
15,700
-81,200
-84% -$7.19M 0.03% 348
2019
Q4 		$9.22M Buy
96,900
+17,300
+22% +$1.5M 0.06% 245
2019
Q3 		$6.07M Sell
79,600
-19,600
-20% -$1.63M 0.06% 272
2019
Q2 		$8.7M Buy
+99,200
New +$8.46M 0.09% 137
2019
Q1 		– Sell
-66,600
Closed -$4.78M – 2523
2018
Q4 		$4.78M Sell
66,600
-117,700
-64% -$9.48M 0.06% 167
2018
Q3 		$17.7M Sell
184,300
-164,400
-47% -$15.9M 0.11% 121
2018
Q2 		$33.2M Buy
348,700
+74,700
+27% +$6.87M 0.17% 79
2018
Q1 		$24M Buy
274,000
+209,000
+322% +$19.1M 0.13% 131
2017
Q4 		$5.52M Buy
+65,000
New +$5.45M 0.15% 110

Other funds holding XBI

Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
BNP Paribas Financial Markets
BNP Paribas Financial Markets Paris, France $206B AUM 31.61% 1-Year Est. Return
Bank of America
Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund Toronto, Ontario, Canada $62.2B AUM 31.35% 1-Year Est. Return
Citigroup
Citigroup New York $235B AUM 32.99% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return
Wells Fargo
Wells Fargo San Francisco, California $530B AUM 22.01% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Two Sigma Securities's XBI Position: Q4 2025 in Review

Two Sigma Securities sold out of State Street SPDR S&P Biotech ETF (XBI) in Q4 2025, closing a stake of 4,935 shares — an estimated $494K sold.

Two Sigma Securities first reported a position in XBI in Q1 2015 and held it in 26 quarters. The position peaked at $10.2M in Q1 2017. 813 funds tracked by Wall St. Rank hold XBI as of Q4 2025.

  • Two Sigma Securities reported no remaining State Street SPDR S&P Biotech ETF position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Securities sold 4,935 State Street SPDR S&P Biotech ETF shares in Q4 2025, an estimated $494K.
  • Two Sigma Securities first reported a position in State Street SPDR S&P Biotech ETF in Q1 2015 and held it in 26 quarters.
  • Two Sigma Securities's State Street SPDR S&P Biotech ETF position peaked at $10.2M in Q1 2017.
  • 813 funds tracked by Wall St. Rank held State Street SPDR S&P Biotech ETF as of Q4 2025.

Based on Two Sigma Securities's 13F filing for Q4 2025, filed 17 Feb 2026.