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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+66.43%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$489M
AUM Growth
-$16.5M
Cap. Flow
-$88.1M
Cap. Flow %
-18.03%
Top 10 Hldgs %
36.36%
Holding
114
New
25
Increased
12
Reduced
45
Closed
25

Top Buys

Rank Stock Value
1
SPRB
Spruce Biosciences
SPRB
+$14.1M
2
AZN icon
AstraZeneca
AZN
+$13.9M
3
SNY icon
Sanofi
SNY
+$10.9M
4
UHS icon
Universal Health Services
UHS
+$10.1M
5
MIRM icon
Mirum Pharmaceuticals
MIRM
+$9.73M

Top Sells

Rank Stock Value
1
JNJ icon
Johnson & Johnson
JNJ
+$17M
2
MCK icon
McKesson
MCK
+$11.8M
3
MOH icon
Molina Healthcare
MOH
+$9.7M
4
AMN icon
AMN Healthcare
AMN
+$9.23M
5
CAH icon
Cardinal Health
CAH
+$8.68M

Sector Composition

Rank Sector Weight
1 Healthcare 81.67%
2 Technology 1.08%
3 Consumer Staples 0.76%
4 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
KOD icon
101
Kodiak Sciences
KOD
$2.84B
– –
-92,150
Closed -$5.46M
CYPH
102
Cypherpunk Technologies Inc
CYPH
$71.7M
– –
-145,200
Closed -$2.88M
MCRB icon
103
PUT
Seres Therapeutics
MCRB
$47.9M
– –
-15,840
Closed -$8.97M
MDT icon
104
Medtronic
MDT
$110B
– –
-39,000
Closed -$4.05M
PMVP icon
105
PMV Pharmaceuticals
PMVP
$62.9M
– –
-1,000
Closed -$36K
QTRX icon
106
Quanterix
QTRX
$180M
– –
-124,609
Closed -$4.2M
RDNT icon
107
RadNet
RDNT
$5.36B
– –
-223,561
Closed -$3.43M
VNDA icon
108
Vanda Pharmaceuticals
VNDA
$308M
– –
-209,205
Closed -$2.02M
SYRS
109
DELISTED
Syros Pharmaceuticals, Inc. Common Stock
SYRS
– –
-16,678
Closed -$1.47M
CSII
110
DELISTED
Cardiovascular Systems, Inc.
CSII
– –
-124,808
Closed -$4.91M
MYOV
111
DELISTED
Myovant Sciences Ltd.
MYOV
– –
-10,100
Closed -$142K
OYST
112
DELISTED
Oyster Point Pharma, Inc. Common Stock
OYST
– –
-105,803
Closed -$2.23M
PANA.U
113
DELISTED
Panacea Acquisition Corp. Units, each consisting of one share of Class A common stock and one-third
PANA.U
– –
-15,000
Closed -$180K
LSACU
114
DELISTED
LifeSci Acquisition Corp. Unit 1 COM & 1 WT
LSACU
– –
-210,000
Closed -$2.86M
1 2 3 4
5

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Sio Capital Management's Q4 2020 Portfolio in Review

As of Q4 2020, Sio Capital Management held 114 positions worth $489M, down 3.3% from $505M the previous quarter. Its ten largest holdings account for 36% of the portfolio.

Sio Capital Management withdrew a net $88.1M in Q4 2020, closing 25 positions and reducing 45 holdings. Its most notable exit was Johnson & Johnson, an estimated $17M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 82% of assets, up from 74% a quarter earlier, followed by Technology and Consumer Staples.

Against the trend, Sio Capital Management opened a new position in Spruce Biosciences worth $15.5M.

  • Sio Capital Management's largest Q4 2020 buy was Spruce Biosciences: 8,489 shares worth $15.5M.
  • Sio Capital Management added most to Kura Oncology in Q4 2020, an estimated $3.55M increase.
  • Sio Capital Management's biggest Q4 2020 reduction was McKesson, cutting an estimated $11.8M.
  • Sio Capital Management fully exited Johnson & Johnson in Q4 2020, selling an estimated $17M.
  • Sio Capital Management's ten largest holdings make up 36% of its $489M portfolio in Q4 2020.
  • Sio Capital Management opened 25 new positions and closed 25 in Q4 2020.
  • Sio Capital Management's portfolio value fell 3.3% quarter-over-quarter to $489M.

Based on Sio Capital Management's 13F filing for Q4 2020, filed 16 Feb 2021.