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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+66.43%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$489M
AUM Growth
-$16.5M
Cap. Flow
-$88.1M
Cap. Flow %
-18.03%
Top 10 Hldgs %
36.36%
Holding
114
New
25
Increased
12
Reduced
45
Closed
25

Top Buys

Rank Stock Value
1
SPRB
Spruce Biosciences
SPRB
+$14.1M
2
AZN icon
AstraZeneca
AZN
+$13.9M
3
SNY icon
Sanofi
SNY
+$10.9M
4
UHS icon
Universal Health Services
UHS
+$10.1M
5
MIRM icon
Mirum Pharmaceuticals
MIRM
+$9.73M

Top Sells

Rank Stock Value
1
JNJ icon
Johnson & Johnson
JNJ
+$17M
2
MCK icon
McKesson
MCK
+$11.8M
3
MOH icon
Molina Healthcare
MOH
+$9.7M
4
AMN icon
AMN Healthcare
AMN
+$9.23M
5
CAH icon
Cardinal Health
CAH
+$8.68M

Sector Composition

Rank Sector Weight
1 Healthcare 81.67%
2 Technology 1.08%
3 Consumer Staples 0.76%
4 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
HROW icon
76
Harrow
HROW
$1.49B
$1.44M 0.29%
209,623
-29,000
-12% -$163K
GYRE icon
77
Gyre Therapeutics
GYRE
$714M
$1.19M 0.24%
25,162
-1,333
-5% -$57.7K
LITS
78
Lite Strategy Inc
LITS
$31.6M
$1.13M 0.23%
21,302
-1,100
-5% -$63.5K
SRRA
79
DELISTED
Sierra Oncology, Inc. Common Stock
SRRA
$1.06M 0.22%
+66,455
New +$923K
AHACU
80
DELISTED
Alpha Healthcare Acquisition Corp Unit
AHACU
$1.06M 0.22%
100,000
– –
DFHTU
81
DELISTED
Deerfield Healthcare Technology Acquisitions Corp. Unit
DFHTU
$750K 0.15%
50,000
– –
NBP
82
NovaBridge Biosciences American Depositary Shares
NBP
$197M
$707K 0.14%
15,000
– –
VINCW
83
DELISTED
Vincerx Pharma, Inc. Warrant
VINCW
$693K 0.14%
+210,000
New +$698K
IDYA icon
84
IDEAYA Biosciences
IDYA
$3.49B
$676K 0.14%
48,298
-6,702
-12% -$90.8K
CASI
85
DELISTED
CASI Pharmaceuticals
CASI
$600K 0.12%
20,343
-2,157
-10% -$46.9K
NGNE icon
86
Neurogene
NGNE
$710M
$540K 0.11%
1,916
– –
RAPT
87
DELISTED
RAPT Therapeutics
RAPT
$282K 0.06%
1,787
– –
TRIL
88
DELISTED
Trillium Therapeutics Inc.
TRIL
$228K 0.05%
+15,500
New +$224K
ZSAN
89
DELISTED
Zosano Pharma Corporation
ZSAN
$225K 0.05%
12,215
-715
-6% -$14K
AFMD
90
DELISTED
Affimed
AFMD
– –
-91,128
Closed -$3.09M
ATNM icon
91
Actinium Pharmaceuticals
ATNM
$24.7M
– –
-189,062
Closed -$1.83M
BNGO icon
92
Bionano Genomics
BNGO
$12.6M
– –
-447
Closed -$174K
CRBP icon
93
PUT
Corbus Pharmaceuticals
CRBP
$180M
– –
-18,533
Closed -$1M
DGX icon
94
Quest Diagnostics
DGX
$26.3B
– –
-75,000
Closed -$8.59M
DYAI icon
95
Dyadic International
DYAI
$37.2M
– –
-209,064
Closed -$1.58M
ELV icon
96
Elevance Health
ELV
$84.9B
– –
-16,031
Closed -$4.31M
ESPR
97
DELISTED
Esperion Therapeutics
ESPR
– –
-61,600
Closed -$2.29M
GDRX icon
98
GoodRx Holdings
GDRX
$1.27B
– –
-1,000
Closed -$56K
GSK icon
99
GSK
GSK
$104B
– –
-165,310
Closed -$7.78M
JNJ icon
100
Johnson & Johnson
JNJ
$619B
– –
-114,400
Closed -$17M
1 2 3
4
5

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Sio Capital Management's Q4 2020 Portfolio in Review

As of Q4 2020, Sio Capital Management held 114 positions worth $489M, down 3.3% from $505M the previous quarter. Its ten largest holdings account for 36% of the portfolio.

Sio Capital Management withdrew a net $88.1M in Q4 2020, closing 25 positions and reducing 45 holdings. Its most notable exit was Johnson & Johnson, an estimated $17M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 82% of assets, up from 74% a quarter earlier, followed by Technology and Consumer Staples.

Against the trend, Sio Capital Management opened a new position in Spruce Biosciences worth $15.5M.

  • Sio Capital Management's largest Q4 2020 buy was Spruce Biosciences: 8,489 shares worth $15.5M.
  • Sio Capital Management added most to Kura Oncology in Q4 2020, an estimated $3.55M increase.
  • Sio Capital Management's biggest Q4 2020 reduction was McKesson, cutting an estimated $11.8M.
  • Sio Capital Management fully exited Johnson & Johnson in Q4 2020, selling an estimated $17M.
  • Sio Capital Management's ten largest holdings make up 36% of its $489M portfolio in Q4 2020.
  • Sio Capital Management opened 25 new positions and closed 25 in Q4 2020.
  • Sio Capital Management's portfolio value fell 3.3% quarter-over-quarter to $489M.

Based on Sio Capital Management's 13F filing for Q4 2020, filed 16 Feb 2021.