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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+1.97%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$332M
AUM Growth
+$18M
Cap. Flow
+$32.2M
Cap. Flow %
9.7%
Top 10 Hldgs %
51.98%
Holding
84
New
23
Increased
13
Reduced
10
Closed
14

Top Buys

Rank Stock Value
1
MSAC
Medicus Sciences Acquisition Corp. Class A Ordinary Share
MSAC
+$22.6M
2
COR icon
Cencora
COR
+$12M
3
IONS icon
Ionis Pharmaceuticals
IONS
+$10.2M
4
CAH icon
Cardinal Health
CAH
+$9.51M
5
MRK icon
Merck
MRK
+$8.65M

Top Sells

Rank Stock Value
1
SOLY
Soliton, Inc.
SOLY
+$16.8M
2
HCA icon
HCA Healthcare
HCA
+$13.7M
3
UHS icon
Universal Health Services
UHS
+$12.8M
4
HQY icon
HealthEquity
HQY
+$4.76M
5
VRTX icon
Vertex Pharmaceuticals
VRTX
+$4.63M

Sector Composition

Rank Sector Weight
1 Healthcare 82.8%
2 Financials 7.24%
3 Consumer Staples 2.98%
4 Industrials 0.5%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
NEOG icon
51
PUT
Neogen
NEOG
$2.52B
$1.14M 0.34%
+25,100
New +$1.07M
LITS
52
Lite Strategy Inc
LITS
$32.8M
$1.14M 0.34%
21,302
– –
ARDX icon
53
Ardelyx
ARDX
$1.22B
$1.09M 0.33%
994,604
+422,522
+74% +$502K
FUSN
54
DELISTED
Fusion Pharmaceuticals Inc. Common Shares
FUSN
$1.08M 0.33%
259,763
– –
VINC
55
DELISTED
Vincerx Pharma, Inc. Common Stock
VINC
$1.04M 0.31%
5,102
– –
SVRA icon
56
Savara
SVRA
$1.12B
$807K 0.24%
+651,170
New +$775K
NXTC icon
57
NextCure
NXTC
$21M
$780K 0.24%
+10,833
New +$906K
CRIS icon
58
CALL
Curis
CRIS
$9.39M
$685K 0.21%
+360
New +$856K
AYLA
59
DELISTED
Ayala Pharmaceuticals, Inc. Common Stock
AYLA
$680K 0.21%
79,964
-238,635
-75% -$2.37M
DCOY
60
Decoy Therapeutics
DCOY
$2.31M
$671K 0.2%
38
– –
XFOR icon
61
X4 Pharmaceuticals
XFOR
$397M
$634K 0.19%
9,230
-17,590
-66% -$2.23M
LOGC
62
DELISTED
LogicBio Therapeutics, Inc. Common Stock
LOGC
$422K 0.13%
182,630
– –
NYXH
63
Nyxoah
NYXH
$143M
$371K 0.11%
16,110
-200
-1% -$4.6K
RCOR.WS
64
DELISTED
Renovacor, Inc. Warrants, entitling the holder thereof to purchase one-half (1/2) of a share of common stock at a price of $11. 50 per whole share
RCOR.WS
$240K 0.07%
400,000
– –
CMAX
65
DELISTED
CareMax, Inc. Class A Common Stock
CMAX
$236K 0.07%
1,025
– –
NGNE icon
66
Neurogene
NGNE
$693M
$185K 0.06%
1,916
– –
UHS icon
67
Universal Health Services
UHS
$10.4B
$161K 0.05%
1,243
-99,808
-99% -$12.8M
MESO
68
Mesoblast
MESO
$1.94B
$128K 0.04%
+13,330
New +$155K
HUMAW icon
69
Humacyte Inc Warrant
HUMAW
$1.09M
$114K 0.03%
49,998
– –
CMAXW
70
DELISTED
CareMax, Inc. Warrant
CMAXW
$20K 0.01%
12,808
– –
CCRN
71
DELISTED
Cross Country Healthcare
CCRN
– –
-199,460
Closed -$4.24M
GILD icon
72
Gilead Sciences
GILD
$161B
– –
-65,500
Closed -$4.58M
GYRE icon
73
Gyre Therapeutics
GYRE
$688M
– –
-83,186
Closed -$2.56M
HCA icon
74
HCA Healthcare
HCA
$88.6B
– –
-56,409
Closed -$13.7M
HQY icon
75
HealthEquity
HQY
$8.64B
– –
-73,458
Closed -$4.76M
1 2
3
4

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KLI
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JA
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WIC
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AAM
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TCM
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CA
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SAM
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Sio Capital Management's Q4 2021 Portfolio in Review

As of Q4 2021, Sio Capital Management held 84 positions worth $332M, up 5.7% from $314M the previous quarter. Its ten largest holdings account for 52% of the portfolio.

Sio Capital Management deployed $32.2M of net new capital in Q4 2021, opening 23 new positions and adding to 13 existing holdings. Its largest new stake was Medicus Sciences Acquisition Corp. Class A Ordinary Share: 2,323,000 shares worth $22.6M.

By sector, the portfolio is most concentrated in Healthcare at 83% of assets, down from 87% a quarter earlier, followed by Financials and Consumer Staples.

On the sell side, the largest reduction was Universal Health Services, an estimated $12.8M trimmed.

  • Sio Capital Management's largest Q4 2021 buy was Medicus Sciences Acquisition Corp. Class A Ordinary Share: 2,323,000 shares worth $22.6M.
  • Sio Capital Management added most to Cardinal Health in Q4 2021, an estimated $9.51M increase.
  • Sio Capital Management's biggest Q4 2021 reduction was Universal Health Services, cutting an estimated $12.8M.
  • Sio Capital Management fully exited Soliton, Inc. in Q4 2021, selling an estimated $16.8M.
  • Sio Capital Management's ten largest holdings make up 52% of its $332M portfolio in Q4 2021.
  • Sio Capital Management opened 23 new positions and closed 14 in Q4 2021.
  • Sio Capital Management's portfolio value rose 5.7% quarter-over-quarter to $332M.

Based on Sio Capital Management's 13F filing for Q4 2021, filed 14 Feb 2022.