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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+19.22%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$420M
AUM Growth
+$109M
Cap. Flow
+$37.3M
Cap. Flow %
8.9%
Top 10 Hldgs %
50.94%
Holding
96
New
34
Increased
16
Reduced
15
Closed
28

Top Buys

Rank Stock Value
1
MRK icon
Merck
MRK
+$14.6M
2
GILD icon
Gilead Sciences
GILD
+$12.1M
3
GSK icon
GSK
GSK
+$9.11M
4
SNY icon
Sanofi
SNY
+$8.01M
5
MDT icon
Medtronic
MDT
+$7.28M

Top Sells

Rank Stock Value
1
JNJ icon
Johnson & Johnson
JNJ
+$18.6M
2
ALNY icon
Alnylam Pharmaceuticals
ALNY
+$8.58M
3
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$7.52M
4
AVTR icon
Avantor
AVTR
+$6.99M
5
INMD icon
InMode
INMD
+$5.79M

Sector Composition

Rank Sector Weight
1 Healthcare 72.48%
2 Financials 0.13%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
BCEL
51
DELISTED
Atreca, Inc. Class A Common Stock
BCEL
$1.32M 0.31%
+85,312
New +$1.03M
BEAT
52
PUT
DELISTED
BioTelemetry, Inc.
BEAT
$1.31M 0.31%
+28,200
New +$1.22M
XCUR icon
53
Exicure
XCUR
$10.2M
$1.29M 0.31%
3,019
-1,479
-33% -$605K
ARVN icon
54
Arvinas
ARVN
$518M
$1.24M 0.29%
+30,052
New +$880K
PGNY icon
55
Progyny
PGNY
$2.44B
$1.23M 0.29%
+44,910
New +$1.08M
OPK icon
56
Opko Health
OPK
$985M
$1.18M 0.28%
+805,311
New +$1.35M
SPPI
57
CALL
DELISTED
Spectrum Pharmaceuticals Inc
SPPI
$1.13M 0.27%
311,400
+18,700
+6% +$151K
OVID icon
58
Ovid Therapeutics
OVID
$414M
$1.1M 0.26%
+264,581
New +$835K
NGNE icon
59
Neurogene
NGNE
$656M
$1.09M 0.26%
+4,409
New +$439K
MRSN
60
DELISTED
Mersana Therapeutics
MRSN
$953K 0.23%
+6,650
New +$486K
ABEO icon
61
Abeona Therapeutics
ABEO
$366M
$924K 0.22%
+11,301
New +$797K
LOGC
62
DELISTED
LogicBio Therapeutics, Inc. Common Stock
LOGC
$906K 0.22%
125,836
+3,300
+3% +$29.8K
KRTX
63
DELISTED
Karuna Therapeutics, Inc. Common Stock
KRTX
$722K 0.17%
+9,588
New +$420K
DTIL icon
64
Precision BioSciences
DTIL
$180M
$603K 0.14%
+1,448
New +$455K
CYPH
65
Cypherpunk Technologies Inc
CYPH
$62.9M
$533K 0.13%
+47,622
New +$482K
CMD
66
PUT
DELISTED
Cantel Medical Corporation
CMD
$518K 0.12%
+7,300
New +$530K
MTD icon
67
PUT
Mettler-Toledo International
MTD
$28.6B
$317K 0.08%
+400
New +$289K
APTO
68
DELISTED
Aptose Biosciences, Inc.
APTO
$284K 0.07%
+111
New +$145K
ACHV icon
69
Achieve Life Sciences
ACHV
$659M
– –
-26,221
Closed -$892K
AMRN
70
Amarin Corp
AMRN
$299M
– –
-10,370
Closed -$3.14M
ATNM icon
71
Actinium Pharmaceuticals
ATNM
$26.3M
– –
-200,105
Closed -$1.38M
AVTR icon
72
Avantor
AVTR
$9.32B
– –
-475,609
Closed -$6.99M
AXSM icon
73
CALL
Axsome Therapeutics
AXSM
$11.2B
– –
-239,000
Closed -$4.84M
AXSM icon
74
Axsome Therapeutics
AXSM
$11.2B
– –
-20,310
Closed -$411K
CCRN
75
DELISTED
Cross Country Healthcare
CCRN
– –
-327,466
Closed -$3.37M
1 2
3
4

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Sio Capital Management's Q4 2019 Portfolio in Review

As of Q4 2019, Sio Capital Management held 96 positions worth $420M, up 35% from $310M the previous quarter. Its ten largest holdings account for 51% of the portfolio.

Sio Capital Management deployed $37.3M of net new capital in Q4 2019, opening 34 new positions and adding to 16 existing holdings. Its largest new stake was Merck: 177,903 shares worth $15.4M.

By sector, the portfolio is most concentrated in Healthcare at 72% of assets, down from 82% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was Alnylam Pharmaceuticals, an estimated $8.58M trimmed.

  • Sio Capital Management's largest Q4 2019 buy was Merck: 177,903 shares worth $15.4M.
  • Sio Capital Management added most to Medtronic in Q4 2019, an estimated $7.28M increase.
  • Sio Capital Management's biggest Q4 2019 reduction was Alnylam Pharmaceuticals, cutting an estimated $8.58M.
  • Sio Capital Management fully exited Johnson & Johnson in Q4 2019, selling an estimated $18.6M.
  • Sio Capital Management's ten largest holdings make up 51% of its $420M portfolio in Q4 2019.
  • Sio Capital Management opened 34 new positions and closed 28 in Q4 2019.
  • Sio Capital Management's portfolio value rose 35% quarter-over-quarter to $420M.

Based on Sio Capital Management's 13F filing for Q4 2019, filed 14 Feb 2020.