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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+18.21%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$636M
AUM Growth
+$241M
Cap. Flow
+$174M
Cap. Flow %
27.38%
Top 10 Hldgs %
53.71%
Holding
77
New
26
Increased
8
Reduced
17
Closed
9

Top Buys

Rank Stock Value
1
CI icon
Cigna
CI
+$48.3M
2
ZBH icon
Zimmer Biomet
ZBH
+$36.6M
3
OGN icon
Organon & Co
OGN
+$27M
4
ICLR icon
Icon
ICLR
+$22.7M
5
WAY
Waystar Holding Corp
WAY
+$21.9M

Top Sells

Rank Stock Value
1
CELC icon
Celcuity
CELC
+$25.4M
2
IRON icon
Disc Medicine
IRON
+$19.2M
3
ALKS icon
Alkermes
ALKS
+$17.4M
4
MRK icon
Merck
MRK
+$14.9M
5
HSIC icon
Henry Schein
HSIC
+$14.5M

Sector Composition

Rank Sector Weight
1 Healthcare 84.1%
2 Industrials 6.79%
3 Consumer Staples 3.98%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
AQST icon
26
Aquestive Therapeutics
AQST
$476M
$6.42M 1.01%
993,095
-505,000
-34% -$3.15M
DRUG
27
Bright Minds Biosciences
DRUG
$776M
$6.39M 1.01%
81,883
-108,881
-57% -$7.28M
EWTX icon
28
Edgewise Therapeutics
EWTX
$4.84B
$5.89M 0.93%
237,481
-69,700
-23% -$1.4M
ABVX
29
Abivax
ABVX
$11B
$5.82M 0.91%
+43,124
New +$4.71M
CRNX icon
30
Crinetics Pharmaceuticals
CRNX
$8.9B
$5.81M 0.91%
124,841
-50,000
-29% -$2.23M
RAPP
31
Rapport Therapeutics
RAPP
$1.96B
$5.62M 0.88%
185,265
– –
COR icon
32
Cencora
COR
$61.5B
$5.37M 0.84%
+15,900
New +$5.42M
MCK icon
33
McKesson
MCK
$99.1B
$5.25M 0.83%
+6,400
New +$5.22M
IRON icon
34
Disc Medicine
IRON
$2.97B
$4.57M 0.72%
57,586
-227,201
-80% -$19.2M
PRQR icon
35
ProQR Therapeutics
PRQR
$270M
$4.37M 0.69%
2,164,181
+89,042
+4% +$208K
FULC icon
36
Fulcrum Therapeutics
FULC
$289M
$4.32M 0.68%
+382,000
New +$3.89M
SVRA icon
37
Savara
SVRA
$1.12B
$3.7M 0.58%
613,888
-112,963
-16% -$553K
ORKA
38
Oruka Therapeutics
ORKA
$5.82B
$3.58M 0.56%
+118,126
New +$3.29M
VTYX
39
DELISTED
Ventyx Biosciences
VTYX
$3.5M 0.55%
387,751
-441,427
-53% -$3.3M
PMVP icon
40
PMV Pharmaceuticals
PMVP
$62.4M
$3.3M 0.52%
2,636,548
– –
SI
41
Shoulder Innovations Inc
SI
$470M
$3.26M 0.51%
227,971
-122,029
-35% -$1.66M
ALGS icon
42
Aligos Therapeutics
ALGS
$29.5M
$3.13M 0.49%
335,937
– –
VIR icon
43
Vir Biotechnology
VIR
$1.54B
$2.88M 0.45%
478,343
– –
ALKS icon
44
Alkermes
ALKS
$8.45B
$2.67M 0.42%
95,353
-579,487
-86% -$17.4M
IDYA icon
45
IDEAYA Biosciences
IDYA
$3.5B
$2.62M 0.41%
75,730
-48,500
-39% -$1.55M
KYMR icon
46
Kymera Therapeutics
KYMR
$8.76B
$2.51M 0.39%
+32,235
New +$2.18M
ELTX icon
47
PUT
Elicio Therapeutics
ELTX
$82.2M
$2.36M 0.37%
+296,900
New +$2.69M
OVID icon
48
Ovid Therapeutics
OVID
$489M
$2.33M 0.37%
1,427,495
– –
CNTX icon
49
Context Therapeutics
CNTX
$57.4M
$1.97M 0.31%
1,341,636
– –
HYPR icon
50
Hyperfine
HYPR
$96.3M
$1.96M 0.31%
+2,000,000
New +$2.41M
1
2
3 4

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Sio Capital Management's Q4 2025 Portfolio in Review

As of Q4 2025, Sio Capital Management held 77 positions worth $636M, up 61% from $395M the previous quarter. Its ten largest holdings account for 54% of the portfolio.

Sio Capital Management deployed $174M of net new capital in Q4 2025, opening 26 new positions and adding to 8 existing holdings. Its largest new stake was Cigna: 172,203 shares worth $47.4M.

By sector, the portfolio is most concentrated in Healthcare at 84% of assets, up from 84% a quarter earlier, followed by Industrials and Consumer Staples.

On the sell side, the largest reduction was Celcuity, an estimated $25.4M trimmed.

  • Sio Capital Management's largest Q4 2025 buy was Cigna: 172,203 shares worth $47.4M.
  • Sio Capital Management added most to Sanofi in Q4 2025, an estimated $20.3M increase.
  • Sio Capital Management's biggest Q4 2025 reduction was Celcuity, cutting an estimated $25.4M.
  • Sio Capital Management fully exited Merck in Q4 2025, selling an estimated $14.9M.
  • Sio Capital Management's ten largest holdings make up 54% of its $636M portfolio in Q4 2025.
  • Sio Capital Management opened 26 new positions and closed 9 in Q4 2025.
  • Sio Capital Management's portfolio value rose 61% quarter-over-quarter to $636M.

Based on Sio Capital Management's 13F filing for Q4 2025, filed 17 Feb 2026.