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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+1.97%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$332M
AUM Growth
+$18M
Cap. Flow
+$32.2M
Cap. Flow %
9.7%
Top 10 Hldgs %
51.98%
Holding
84
New
23
Increased
13
Reduced
10
Closed
14

Top Buys

Rank Stock Value
1
MSAC
Medicus Sciences Acquisition Corp. Class A Ordinary Share
MSAC
+$22.6M
2
COR icon
Cencora
COR
+$12M
3
IONS icon
Ionis Pharmaceuticals
IONS
+$10.2M
4
CAH icon
Cardinal Health
CAH
+$9.51M
5
MRK icon
Merck
MRK
+$8.65M

Top Sells

Rank Stock Value
1
SOLY
Soliton, Inc.
SOLY
+$16.8M
2
HCA icon
HCA Healthcare
HCA
+$13.7M
3
UHS icon
Universal Health Services
UHS
+$12.8M
4
HQY icon
HealthEquity
HQY
+$4.76M
5
VRTX icon
Vertex Pharmaceuticals
VRTX
+$4.63M

Sector Composition

Rank Sector Weight
1 Healthcare 82.8%
2 Financials 7.24%
3 Consumer Staples 2.98%
4 Industrials 0.5%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
OYST
26
DELISTED
Oyster Point Pharma, Inc. Common Stock
OYST
$3.32M 1%
+181,857
New +$2.31M
BCYC
27
Bicycle Therapeutics
BCYC
$276M
$3.29M 0.99%
+54,000
New +$2.98M
HZNP
28
DELISTED
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
$3.16M 0.95%
29,319
– –
VKTX icon
29
Viking Therapeutics
VKTX
$3.88B
$3.04M 0.92%
660,813
– –
INGN icon
30
Inogen
INGN
$185M
$3M 0.91%
+88,291
New +$3.21M
SYRS
31
DELISTED
Syros Pharmaceuticals, Inc. Common Stock
SYRS
$2.94M 0.89%
90,068
– –
MRUS
32
DELISTED
Merus
MRUS
$2.86M 0.86%
+90,000
New +$2.54M
NTUS
33
DELISTED
Natus Medical Inc
NTUS
$2.56M 0.77%
107,695
+68,341
+174% +$1.69M
NBSE
34
DELISTED
NeuBase Therapeutics, Inc. Common Stock
NBSE
$2.55M 0.77%
45,322
– –
OBIO icon
35
Orchestra BioMed
OBIO
$250M
$2.52M 0.76%
250,000
– –
EUCRU
36
DELISTED
Eucrates Biomedical Acquisition Corp. Unit
EUCRU
$2.48M 0.75%
248,674
– –
AMED
37
DELISTED
Amedisys
AMED
$2.43M 0.73%
+15,000
New +$2.41M
RIGL icon
38
Rigel Pharmaceuticals
RIGL
$725M
$2.42M 0.73%
91,362
– –
SYRE icon
39
Spyre Therapeutics
SYRE
$8.8B
$2.37M 0.71%
19,940
+2,100
+12% +$331K
PNT
40
DELISTED
POINT Biopharma Global Inc. Common Stock
PNT
$2.12M 0.64%
+377,684
New +$2.83M
SRRA
41
DELISTED
Sierra Oncology, Inc. Common Stock
SRRA
$2.08M 0.63%
95,450
– –
MBRX icon
42
Moleculin Biotech
MBRX
$2.89M
$1.94M 0.58%
2,775
– –
DTIL icon
43
Precision BioSciences
DTIL
$186M
$1.9M 0.57%
8,572
– –
CBAY
44
DELISTED
Cymabay Therapeutics
CBAY
$1.9M 0.57%
562,339
– –
ANIP icon
45
ANI Pharmaceuticals
ANIP
$1.82B
$1.84M 0.56%
+40,000
New +$1.72M
BGMS
46
Bio Green Med Solution Inc
BGMS
$5.46M
$1.64M 0.5%
117
– –
ELEV
47
DELISTED
Elevation Oncology
ELEV
$1.5M 0.45%
+250,000
New +$1.73M
BLU
48
PUT
DELISTED
BELLUS Health Inc.
BLU
$1.46M 0.44%
+181,800
New +$1.21M
CYPH
49
Cypherpunk Technologies Inc
CYPH
$73.8M
$1.43M 0.43%
44,000
– –
ASLN
50
DELISTED
ASLAN Pharmaceuticals Limited American Depositary Shares
ASLN
$1.42M 0.43%
31,769
– –
1
2
3 4

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Sio Capital Management's Q4 2021 Portfolio in Review

As of Q4 2021, Sio Capital Management held 84 positions worth $332M, up 5.7% from $314M the previous quarter. Its ten largest holdings account for 52% of the portfolio.

Sio Capital Management deployed $32.2M of net new capital in Q4 2021, opening 23 new positions and adding to 13 existing holdings. Its largest new stake was Medicus Sciences Acquisition Corp. Class A Ordinary Share: 2,323,000 shares worth $22.6M.

By sector, the portfolio is most concentrated in Healthcare at 83% of assets, down from 87% a quarter earlier, followed by Financials and Consumer Staples.

On the sell side, the largest reduction was Universal Health Services, an estimated $12.8M trimmed.

  • Sio Capital Management's largest Q4 2021 buy was Medicus Sciences Acquisition Corp. Class A Ordinary Share: 2,323,000 shares worth $22.6M.
  • Sio Capital Management added most to Cardinal Health in Q4 2021, an estimated $9.51M increase.
  • Sio Capital Management's biggest Q4 2021 reduction was Universal Health Services, cutting an estimated $12.8M.
  • Sio Capital Management fully exited Soliton, Inc. in Q4 2021, selling an estimated $16.8M.
  • Sio Capital Management's ten largest holdings make up 52% of its $332M portfolio in Q4 2021.
  • Sio Capital Management opened 23 new positions and closed 14 in Q4 2021.
  • Sio Capital Management's portfolio value rose 5.7% quarter-over-quarter to $332M.

Based on Sio Capital Management's 13F filing for Q4 2021, filed 14 Feb 2022.