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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
-7.3%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$314M
AUM Growth
-$88.6M
Cap. Flow
-$54.8M
Cap. Flow %
-17.46%
Top 10 Hldgs %
50.02%
Holding
85
New
12
Increased
22
Reduced
16
Closed
24

Top Buys

Rank Stock Value
1
LKFT
Lakefront Biotherapeutics American Depositary Shares
LKFT
+$13.3M
2
CI icon
Cigna
CI
+$11.1M
3
MRK icon
Merck
MRK
+$9.51M
4
CAH icon
Cardinal Health
CAH
+$5.84M
5
RCOR
Renovacor, Inc.
RCOR
+$5.23M

Top Sells

Rank Stock Value
1
HRC
HILL-ROM HOLDINGS, INC.
HRC
+$8.71M
2
AMGN icon
Amgen
AMGN
+$8.53M
3
AFMD
Affimed
AFMD
+$6.07M
4
CHRS icon
Coherus Oncology
CHRS
+$5.72M
5
SYNH
Syneos Health, Inc. Class A Common Stock
SYNH
+$5.6M

Sector Composition

Rank Sector Weight
1 Healthcare 87.44%
2 Consumer Staples 2.92%
3 Industrials 0.71%
4 Financials 0.56%
5 Technology 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SYRS
26
DELISTED
Syros Pharmaceuticals, Inc. Common Stock
SYRS
$4.03M 1.28%
90,068
+10,068
+13% +$492K
SPRB
27
Spruce Biosciences
SPRB
$127M
$3.62M 1.16%
8,040
-590
-7% -$370K
AYLA
28
DELISTED
Ayala Pharmaceuticals, Inc. Common Stock
AYLA
$3.61M 1.15%
318,599
-224,378
-41% -$2.69M
SYRE icon
29
Spyre Therapeutics
SYRE
$9.11B
$3.55M 1.13%
17,840
+1,734
+11% +$303K
RIGL icon
30
Rigel Pharmaceuticals
RIGL
$716M
$3.32M 1.06%
91,362
+8,390
+10% +$330K
NBSE
31
DELISTED
NeuBase Therapeutics, Inc. Common Stock
NBSE
$3.27M 1.04%
45,322
+1,887
+4% +$144K
HZNP
32
DELISTED
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
$3.21M 1.02%
29,319
-38,152
-57% -$3.96M
MBRX icon
33
Moleculin Biotech
MBRX
$2.89M
$3.12M 1%
2,775
+95
+4% +$111K
RDUS
34
DELISTED
Radius Health, Inc.
RDUS
$3M 0.96%
241,905
+948
+0.4% +$13.7K
DTIL icon
35
Precision BioSciences
DTIL
$188M
$2.97M 0.95%
8,572
-1,209
-12% -$410K
GYRE icon
36
Gyre Therapeutics
GYRE
$686M
$2.56M 0.82%
83,186
– –
EUCRU
37
DELISTED
Eucrates Biomedical Acquisition Corp. Unit
EUCRU
$2.47M 0.79%
248,674
-51,326
-17% -$513K
OBIO icon
38
Orchestra BioMed
OBIO
$256M
$2.47M 0.79%
250,000
– –
ASLN
39
DELISTED
ASLAN Pharmaceuticals Limited American Depositary Shares
ASLN
$2.26M 0.72%
31,769
-5,444
-15% -$619K
BGMS
40
Bio Green Med Solution Inc
BGMS
$5.41M
$2.23M 0.71%
117
+1
+0.9% +$19.2K
SRRA
41
DELISTED
Sierra Oncology, Inc. Common Stock
SRRA
$2.09M 0.67%
95,450
+2,198
+2% +$44K
FUSN
42
DELISTED
Fusion Pharmaceuticals Inc. Common Shares
FUSN
$2.06M 0.66%
259,763
-6,344
-2% -$53.4K
CBAY
43
DELISTED
Cymabay Therapeutics
CBAY
$2.05M 0.65%
562,339
– –
QNCX icon
44
PUT
Quince Therapeutics
QNCX
$26.8M
$2.04M 0.65%
+111
New +$1.77M
CYPH
45
Cypherpunk Technologies Inc
CYPH
$73.5M
$1.76M 0.56%
+44,000
New +$828K
VINC
46
DELISTED
Vincerx Pharma, Inc. Common Stock
VINC
$1.65M 0.53%
5,102
-1,944
-28% -$567K
PTGX icon
47
Protagonist Therapeutics
PTGX
$8.73B
$1.59M 0.51%
+90,000
New +$3.84M
EVLO
48
PUT
DELISTED
Evelo Biosciences, Inc. Common Stock
EVLO
$1.45M 0.46%
+10,315
New +$2.04M
DCOY
49
Decoy Therapeutics
DCOY
$2.32M
$1.38M 0.44%
38
– –
ARNA
50
DELISTED
Arena Pharmaceuticals Inc
ARNA
$1.29M 0.41%
21,738
– –
1
2
3 4

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Sio Capital Management's Q3 2021 Portfolio in Review

As of Q3 2021, Sio Capital Management held 85 positions worth $314M, down 22% from $402M the previous quarter. Its ten largest holdings account for 50% of the portfolio.

Sio Capital Management withdrew a net $54.8M in Q3 2021, closing 24 positions and reducing 16 holdings. Its most notable exit was HILL-ROM HOLDINGS, INC., an estimated $8.71M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 87% of assets, up from 79% a quarter earlier, followed by Consumer Staples and Industrials.

Against the trend, Sio Capital Management opened a new position in Lakefront Biotherapeutics American Depositary Shares worth $11.8M.

  • Sio Capital Management's largest Q3 2021 buy was Lakefront Biotherapeutics American Depositary Shares: 224,719 shares worth $11.8M.
  • Sio Capital Management added most to Cigna in Q3 2021, an estimated $11.1M increase.
  • Sio Capital Management's biggest Q3 2021 reduction was Horizon Therapeutics Public Limited Company Ordinary Shares, cutting an estimated $3.96M.
  • Sio Capital Management fully exited HILL-ROM HOLDINGS, INC. in Q3 2021, selling an estimated $8.71M.
  • Sio Capital Management's ten largest holdings make up 50% of its $314M portfolio in Q3 2021.
  • Sio Capital Management opened 12 new positions and closed 24 in Q3 2021.
  • Sio Capital Management's portfolio value fell 22% quarter-over-quarter to $314M.

Based on Sio Capital Management's 13F filing for Q3 2021, filed 15 Nov 2021.