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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+19.22%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$420M
AUM Growth
+$109M
Cap. Flow
+$37.3M
Cap. Flow %
8.9%
Top 10 Hldgs %
50.94%
Holding
96
New
34
Increased
16
Reduced
15
Closed
28

Top Buys

Rank Stock Value
1
MRK icon
Merck
MRK
+$14.6M
2
GILD icon
Gilead Sciences
GILD
+$12.1M
3
GSK icon
GSK
GSK
+$9.11M
4
SNY icon
Sanofi
SNY
+$8.01M
5
MDT icon
Medtronic
MDT
+$7.28M

Top Sells

Rank Stock Value
1
JNJ icon
Johnson & Johnson
JNJ
+$18.6M
2
ALNY icon
Alnylam Pharmaceuticals
ALNY
+$8.58M
3
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$7.52M
4
AVTR icon
Avantor
AVTR
+$6.99M
5
INMD icon
InMode
INMD
+$5.79M

Sector Composition

Rank Sector Weight
1 Healthcare 72.48%
2 Financials 0.13%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
HRC
26
DELISTED
HILL-ROM HOLDINGS, INC.
HRC
$4.56M 1.09%
40,182
– –
ALNY icon
27
Alnylam Pharmaceuticals
ALNY
$27.5B
$4.22M 1%
36,632
-86,021
-70% -$8.58M
ALXN
28
DELISTED
Alexion Pharmaceuticals
ALXN
$4.09M 0.97%
37,781
-13,500
-26% -$1.44M
ARNA
29
DELISTED
Arena Pharmaceuticals Inc
ARNA
$4.06M 0.97%
89,357
+45,500
+104% +$2.15M
ITGR icon
30
Integer Holdings
ITGR
$4.12B
$3.59M 0.86%
44,679
-5,917
-12% -$452K
ESPR
31
DELISTED
Esperion Therapeutics
ESPR
$3.38M 0.8%
+56,658
New +$2.55M
SYNH
32
DELISTED
Syneos Health, Inc. Class A Common Stock
SYNH
$3.17M 0.76%
53,297
– –
SYRS
33
DELISTED
Syros Pharmaceuticals, Inc. Common Stock
SYRS
$3.1M 0.74%
+44,853
New +$2.72M
SAGE
34
PUT
DELISTED
Sage Therapeutics
SAGE
$3.02M 0.72%
+41,900
New +$5.15M
TRIL
35
DELISTED
Trillium Therapeutics Inc.
TRIL
$2.83M 0.68%
+2,751,186
New +$1.05M
AFMD
36
DELISTED
Affimed
AFMD
$2.79M 0.66%
+101,820
New +$2.72M
HROW icon
37
Harrow
HROW
$1.45B
$2.68M 0.64%
344,940
+6,326
+2% +$36.6K
PFNX
38
DELISTED
Pfenex Inc.
PFNX
$2.55M 0.61%
232,626
+39,018
+20% +$388K
LRMR icon
39
Larimar Therapeutics
LRMR
$397M
$2.53M 0.6%
+190,264
New +$1.82M
UROV
40
DELISTED
Urovant Sciences Ltd.
UROV
$2.49M 0.59%
160,442
-28,400
-15% -$308K
MEDP icon
41
Medpace
MEDP
$16.1B
$2.24M 0.53%
26,601
-24,800
-48% -$1.92M
ASLN
42
DELISTED
ASLAN Pharmaceuticals Limited American Depositary Shares
ASLN
$2.07M 0.49%
+25,449
New +$1.82M
RDUS
43
DELISTED
Radius Health, Inc.
RDUS
$2.02M 0.48%
+100,000
New +$2.43M
WVE icon
44
CALL
Wave Life Sciences
WVE
$1.09B
$1.76M 0.42%
+219,100
New +$5.37M
PHG icon
45
PUT
Philips
PHG
$25.7B
$1.65M 0.39%
+42,523
New +$1.54M
BNGO icon
46
Bionano Genomics
BNGO
$12.3M
$1.5M 0.36%
2,018
-381
-16% -$223K
RVNC
47
DELISTED
Revance Therapeutics, Inc.
RVNC
$1.42M 0.34%
87,700
-217,964
-71% -$3.38M
HALO icon
48
Halozyme
HALO
$9.79B
$1.4M 0.33%
79,067
-241,306
-75% -$4.18M
GYRE icon
49
Gyre Therapeutics
GYRE
$641M
$1.39M 0.33%
27,290
-3,334
-11% -$140K
ARAV
50
DELISTED
Aravive, Inc. Common Stock
ARAV
$1.34M 0.32%
+98,201
New +$868K
1
2
3 4

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Sio Capital Management's Q4 2019 Portfolio in Review

As of Q4 2019, Sio Capital Management held 96 positions worth $420M, up 35% from $310M the previous quarter. Its ten largest holdings account for 51% of the portfolio.

Sio Capital Management deployed $37.3M of net new capital in Q4 2019, opening 34 new positions and adding to 16 existing holdings. Its largest new stake was Merck: 177,903 shares worth $15.4M.

By sector, the portfolio is most concentrated in Healthcare at 72% of assets, down from 82% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was Alnylam Pharmaceuticals, an estimated $8.58M trimmed.

  • Sio Capital Management's largest Q4 2019 buy was Merck: 177,903 shares worth $15.4M.
  • Sio Capital Management added most to Medtronic in Q4 2019, an estimated $7.28M increase.
  • Sio Capital Management's biggest Q4 2019 reduction was Alnylam Pharmaceuticals, cutting an estimated $8.58M.
  • Sio Capital Management fully exited Johnson & Johnson in Q4 2019, selling an estimated $18.6M.
  • Sio Capital Management's ten largest holdings make up 51% of its $420M portfolio in Q4 2019.
  • Sio Capital Management opened 34 new positions and closed 28 in Q4 2019.
  • Sio Capital Management's portfolio value rose 35% quarter-over-quarter to $420M.

Based on Sio Capital Management's 13F filing for Q4 2019, filed 14 Feb 2020.