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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+16.75%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$226M
AUM Growth
+$79.9M
Cap. Flow
+$76M
Cap. Flow %
33.66%
Top 10 Hldgs %
58.47%
Holding
54
New
20
Increased
12
Reduced
7
Closed
12

Top Buys

Rank Stock Value
1
DYAX
DYAX CORPORATION
DYAX
+$22.1M
2
MTEM
Molecular Templates, Inc.
MTEM
+$12M
3
SNY icon
Sanofi
SNY
+$10.6M
4
MCK icon
McKesson
MCK
+$10.6M
5
AAAP
Advanced Accelerator Applications S.A.
AAAP
+$8.11M

Top Sells

Rank Stock Value
1
JNJ icon
Johnson & Johnson
JNJ
+$7.98M
2
CAH icon
Cardinal Health
CAH
+$7.29M
3
MDT icon
Medtronic
MDT
+$5.89M
4
AMGN icon
Amgen
AMGN
+$5.23M
5
ALNY icon
Alnylam Pharmaceuticals
ALNY
+$5.22M

Sector Composition

Rank Sector Weight
1 Healthcare 78%
2 Financials 2.43%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
TEVA icon
26
Teva Pharmaceuticals
TEVA
$40.4B
$2.8M 1.24%
+42,610
New +$2.63M
MDT icon
27
Medtronic
MDT
$112B
$2.69M 1.19%
35,000
-78,289
-69% -$5.89M
HRTX icon
28
Heron Therapeutics
HRTX
$93.4M
$2.66M 1.18%
+99,772
New +$2.67M
BEAT
29
DELISTED
BioTelemetry, Inc.
BEAT
$2.24M 0.99%
+191,755
New +$2.43M
SRPT icon
30
PUT
Sarepta Therapeutics
SRPT
$1.64B
$1.93M 0.85%
+50,000
New +$1.62M
MTEM
31
DELISTED
Molecular Templates, Inc.
MTEM
$1.92M 0.85%
+24,267
New +$12M
FWP
32
DELISTED
Forward Pharma A/S American Depositary Shares
FWP
$1.9M 0.84%
+14,286
New +$2.29M
AVDL
33
DELISTED
Avadel Pharmaceuticals
AVDL
$1.51M 0.67%
124,017
-115,681
-48% -$1.8M
RAD
34
DELISTED
Rite Aid Corporation
RAD
$1.35M 0.6%
+8,606
New +$1.27M
LNTH icon
35
Lantheus
LNTH
$6.51B
$1.23M 0.54%
+363,748
New +$1.31M
SCYX icon
36
SCYNEXIS
SCYX
$37.4M
$1.01M 0.45%
2,027
– –
AGRX
37
DELISTED
Agile Therapeutics
AGRX
$725K 0.32%
37
-3
-8% -$47.5K
PETX
38
DELISTED
Aratana Therapeutics, Inc.
PETX
$543K 0.24%
97,376
-42,780
-31% -$283K
OASM
39
DELISTED
Oasmia Pharmaceutical AB
OASM
$445K 0.2%
+123,000
New +$484K
RLYP
40
DELISTED
RELYPSA INC COM
RLYP
$283K 0.13%
+10,000
New +$215K
NSPR icon
41
InspireMD
NSPR
$31.4M
– –
0
– –
IMNP
42
DELISTED
Immune Pharmaceuticals Inc.
IMNP
$144K 0.06%
9,883
– –
ALNY icon
43
Alnylam Pharmaceuticals
ALNY
$38.3B
– –
-64,996
Closed -$5.22M
AMGN icon
44
Amgen
AMGN
$209B
– –
-37,832
Closed -$5.23M
CAH icon
45
Cardinal Health
CAH
$53.7B
– –
-94,868
Closed -$7.29M
IRWD icon
46
Ironwood Pharmaceuticals
IRWD
$586M
– –
-128,236
Closed -$1.12M
JNJ icon
47
Johnson & Johnson
JNJ
$640B
– –
-85,438
Closed -$7.98M
UTHR icon
48
United Therapeutics
UTHR
$26.1B
– –
-37,677
Closed -$4.95M
MRTX
49
DELISTED
Mirati Therapeutics, Inc. Common Stock
MRTX
– –
-57,605
Closed -$1.98M
HNGR
50
DELISTED
Hanger Inc.
HNGR
– –
-91,995
Closed -$1.25M
1
2
3

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Sio Capital Management's Q4 2015 Portfolio in Review

As of Q4 2015, Sio Capital Management held 54 positions worth $226M, up 55% from $146M the previous quarter. Its ten largest holdings account for 58% of the portfolio.

Sio Capital Management deployed $76M of net new capital in Q4 2015, opening 20 new positions and adding to 12 existing holdings. Its largest new stake was DYAX CORPORATION: 687,600 shares worth $25.9M.

By sector, the portfolio is most concentrated in Healthcare at 78% of assets, down from 96% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was Medtronic, an estimated $5.89M trimmed.

  • Sio Capital Management's largest Q4 2015 buy was DYAX CORPORATION: 687,600 shares worth $25.9M.
  • Sio Capital Management added most to Sanofi in Q4 2015, an estimated $10.6M increase.
  • Sio Capital Management's biggest Q4 2015 reduction was Medtronic, cutting an estimated $5.89M.
  • Sio Capital Management fully exited Johnson & Johnson in Q4 2015, selling an estimated $7.98M.
  • Sio Capital Management's ten largest holdings make up 58% of its $226M portfolio in Q4 2015.
  • Sio Capital Management opened 20 new positions and closed 12 in Q4 2015.
  • Sio Capital Management's portfolio value rose 55% quarter-over-quarter to $226M.

Based on Sio Capital Management's 13F filing for Q4 2015, filed 16 Feb 2016.