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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+31.09%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$9.98B
AUM Growth
+$1.87B
Cap. Flow
+$293M
Cap. Flow %
2.94%
Top 10 Hldgs %
50.46%
Holding
103
New
29
Increased
20
Reduced
12
Closed
12

Top Buys

Rank Stock Value
1
INSM icon
Insmed
INSM
+$321M
2
IRTC icon
iRhythm Holdings
IRTC
+$209M
3
APLS
Apellis Pharmaceuticals
APLS
+$180M
4
RGEN icon
Repligen
RGEN
+$167M
5
COGT icon
Cogent Biosciences
COGT
+$116M

Top Sells

Rank Stock Value
1
RNAM
Avidity Biosciences
RNAM
+$496M
2
AKRO
Akero Therapeutics
AKRO
+$260M
3
MRUS
Merus
MRUS
+$191M
4
NTRA icon
Natera
NTRA
+$104M
5
SYK icon
Stryker
SYK
+$89.3M

Sector Composition

Rank Sector Weight
1 Healthcare 99.9%
2 Financials 0.1%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
RNAM
101
DELISTED
Avidity Biosciences
RNAM
– –
-11,372,829
Closed -$496M
LENZ
102
LENZ Therapeutics
LENZ
$168M
– –
-863,389
Closed -$40.2M
ADGM
103
Adagio Medical Holdings
ADGM
$15.2M
– –
-209,361
Closed -$406K
1 2 3 4
5

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IIM
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ACA
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VPIM
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MF
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RTW Investments's Q4 2025 Portfolio in Review

As of Q4 2025, RTW Investments held 103 positions worth $9.98B, up 23% from $8.12B the previous quarter. Its ten largest holdings account for 50% of the portfolio.

RTW Investments's Q4 2025 filing shows 29 new, 20 increased, 12 reduced and 12 closed positions. Its largest new stake was iRhythm Holdings: 1,181,990 shares worth $210M. The largest sale was Avidity Biosciences, an estimated $496M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q4 2025 buy was iRhythm Holdings: 1,181,990 shares worth $210M.
  • RTW Investments added most to Insmed in Q4 2025, an estimated $321M increase.
  • RTW Investments's biggest Q4 2025 reduction was Natera, cutting an estimated $104M.
  • RTW Investments fully exited Avidity Biosciences in Q4 2025, selling an estimated $496M.
  • RTW Investments's ten largest holdings make up 50% of its $9.98B portfolio in Q4 2025.
  • RTW Investments opened 29 new positions and closed 12 in Q4 2025.
  • RTW Investments's portfolio value rose 23% quarter-over-quarter to $9.98B.

Based on RTW Investments's 13F filing for Q4 2025, filed 17 Feb 2026.