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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
-13.26%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$4.83B
AUM Growth
-$2.02B
Cap. Flow
-$868M
Cap. Flow %
-17.97%
Top 10 Hldgs %
38.68%
Holding
126
New
2
Increased
20
Reduced
30
Closed
20

Top Buys

Rank Stock Value
1
PTGX icon
Protagonist Therapeutics
PTGX
+$61.8M
2
MASI
Masimo
MASI
+$53.3M
3
CCCC icon
C4 Therapeutics
CCCC
+$49.5M
4
CINC
CinCor Pharma, Inc. Common Stock
CINC
+$28.5M
5
TSVT
2seventy bio
TSVT
+$20.9M

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$423M
2
ISEE
IVERIC bio, Inc. Common Stock
ISEE
+$112M
3
APLS
Apellis Pharmaceuticals
APLS
+$85.6M
4
ITOS
iTeos Therapeutics
ITOS
+$67.7M
5
IDYA icon
IDEAYA Biosciences
IDYA
+$59.6M

Sector Composition

Rank Sector Weight
1 Healthcare 99.3%
2 Financials 0.6%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PRCT icon
76
Procept Biorobotics
PRCT
$1.17B
$5.64M 0.12%
161,138
-32,998
-17% -$794K
ARYD
77
DELISTED
ARYA Sciences Acquisition Corp IV Class A Odinary Shares
ARYD
$4.9M 0.1%
500,000
– –
SMIHU
78
DELISTED
Summit Healthcare Acquisition Corp. Units
SMIHU
$4.89M 0.1%
500,000
– –
ARYE
79
DELISTED
ARYA Sciences Acquisition Corp V Class A Ordinary Shares
ARYE
$4.86M 0.1%
500,000
– –
NAUT icon
80
Nautilus Biotechnolgy
NAUT
$115M
$4.77M 0.1%
1,100,000
– –
ROIV icon
81
Roivant Sciences
ROIV
$26.2B
$3.96M 0.08%
802,717
– –
PNT
82
DELISTED
POINT Biopharma Global Inc. Common Stock
PNT
$3.9M 0.08%
490,000
– –
FVAM
83
DELISTED
5:01 Acquisition Corp
FVAM
$3.86M 0.08%
392,000
– –
JNJ icon
84
Johnson & Johnson
JNJ
$625B
$3.21M 0.07%
18,127
-107,000
-86% -$18.2M
MSAC
85
DELISTED
Medicus Sciences Acquisition Corp. Class A Ordinary Share
MSAC
$2.93M 0.06%
300,000
– –
ASLN
86
DELISTED
ASLAN Pharmaceuticals Limited American Depositary Shares
ASLN
$2.92M 0.06%
81,250
– –
IMTX icon
87
Immatics
IMTX
$1.32B
$2.8M 0.06%
350,000
– –
GTH
88
DELISTED
Genetron Holdings Limited ADS
GTH
$2.63M 0.05%
399,654
-74,311
-16% -$814K
APLS
89
DELISTED
Apellis Pharmaceuticals
APLS
$2.6M 0.05%
51,194
-1,939,210
-97% -$85.6M
RXST icon
90
RxSight
RXST
$260M
$1.86M 0.04%
150,000
– –
SOPH icon
91
SOPHiA GENETICS
SOPH
$647M
$1.75M 0.04%
226,589
-73,411
-24% -$825K
APEN
92
DELISTED
Apollo Endosurgery, Inc.
APEN
$1.56M 0.03%
258,064
– –
MXCT icon
93
MaxCyte
MXCT
$126M
$1.4M 0.03%
199,567
-75,433
-27% -$515K
CNTB
94
Connect Biopharma Holdings
CNTB
$139M
$1.35M 0.03%
446,564
-3,436
-0.8% -$14.5K
ISO
95
DELISTED
IsoPlexis Corporation Common Stock
ISO
$1.25M 0.03%
365,000
– –
MIRO
96
DELISTED
Miromatrix Medical Inc. Common Stock
MIRO
$1.11M 0.02%
280,000
– –
TBIO
97
DELISTED
Telesis Bio, Inc. Common Stock
TBIO
$1.07M 0.02%
11,111
– –
RCEL icon
98
Avita Medical
RCEL
$240M
$905K 0.02%
106,667
– –
AKYA
99
DELISTED
Akoya BioSciences
AKYA
$854K 0.02%
77,676
-22,324
-22% -$259K
MASS icon
100
908 Devices
MASS
$364M
$760K 0.02%
40,000
– –
2 3
4
5 6

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RTW Investments's Q1 2022 Portfolio in Review

As of Q1 2022, RTW Investments held 126 positions worth $4.83B, down 29% from $6.85B the previous quarter. Its ten largest holdings account for 39% of the portfolio.

RTW Investments withdrew a net $868M in Q1 2022, closing 20 positions and reducing 30 holdings. Its most notable exit was State Street SPDR S&P 500 ETF Trust, an estimated $423M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 99% of assets, up from 93% a quarter earlier, followed by Financials.

Against the trend, RTW Investments opened a new position in CinCor Pharma, Inc. Common Stock worth $24.4M.

  • RTW Investments's largest Q1 2022 buy was CinCor Pharma, Inc. Common Stock: 1,389,705 shares worth $24.4M.
  • RTW Investments added most to Protagonist Therapeutics in Q1 2022, an estimated $61.8M increase.
  • RTW Investments's biggest Q1 2022 reduction was Apellis Pharmaceuticals, cutting an estimated $85.6M.
  • RTW Investments fully exited State Street SPDR S&P 500 ETF Trust in Q1 2022, selling an estimated $423M.
  • RTW Investments's ten largest holdings make up 39% of its $4.83B portfolio in Q1 2022.
  • RTW Investments opened 2 new positions and closed 20 in Q1 2022.
  • RTW Investments's portfolio value fell 29% quarter-over-quarter to $4.83B.

Based on RTW Investments's 13F filing for Q1 2022, filed 16 May 2022.