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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+2.62%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.41B
AUM Growth
+$445M
Cap. Flow
+$949M
Cap. Flow %
14.82%
Top 10 Hldgs %
42.9%
Holding
120
New
18
Increased
32
Reduced
16
Closed
9

Top Buys

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$365M
2
QDEL icon
QuidelOrtho
QDEL
+$162M
3
RXDX
Prometheus Biosciences, Inc. Common Stock
RXDX
+$67.4M
4
PTCT icon
PTC Therapeutics
PTCT
+$63.7M
5
ITOS
iTeos Therapeutics
ITOS
+$61M

Top Sells

Rank Stock Value
1
KRRO icon
Korro Bio
KRRO
+$86.8M
2
RCKT icon
Rocket Pharmaceuticals
RCKT
+$73.8M
3
FPRX
Five Prime Therapeutics, Inc.
FPRX
+$42.8M
4
IMVT icon
Immunovant
IMVT
+$32.6M
5
PEN icon
Penumbra
PEN
+$20.7M

Sector Composition

Rank Sector Weight
1 Healthcare 88.33%
2 Financials 0.35%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CNTB
76
Connect Biopharma Holdings
CNTB
$139M
$8.32M 0.13%
+450,000
New +$7.66M
EPIX
77
DELISTED
ESSA Pharma
EPIX
$8.24M 0.13%
+283,692
New +$6.59M
SRRK icon
78
Scholar Rock
SRRK
$6.44B
$8.19M 0.13%
161,612
-4,571
-3% -$253K
MLTX icon
79
MoonLake Immunotherapeutics
MLTX
$1.55B
$7.66M 0.12%
750,000
– –
NAUT icon
80
Nautilus Biotechnolgy
NAUT
$115M
$6.89M 0.11%
500,000
– –
CERE
81
DELISTED
Cerevel Therapeutics Holdings, Inc. Common Stock
CERE
$6.87M 0.11%
500,000
– –
OLK
82
DELISTED
Olink Holding AB (publ) American Depositary Shares
OLK
$6.69M 0.1%
+185,838
New +$6.26M
TNGX icon
83
Tango Therapeutics
TNGX
$4.41B
$6.67M 0.1%
600,000
– –
SNCE
84
DELISTED
Science 37 Holdings, Inc. Common Stock
SNCE
$6.59M 0.1%
32,500
– –
RACB
85
DELISTED
Research Alliance Corp. II Class A Common Stock
RACB
$6.53M 0.1%
+637,000
New +$6.52M
BLSA
86
DELISTED
BCLS Acquisition Corp. Class A Ordinary Shares
BLSA
$6.47M 0.1%
612,500
– –
ITMR
87
DELISTED
Itamar Medical Ltd. American Depository Shares
ITMR
$6.43M 0.1%
268,609
+40,000
+17% +$951K
AFIB
88
DELISTED
Acutus Medical Inc
AFIB
$6.04M 0.09%
451,834
– –
RCEL icon
89
Avita Medical
RCEL
$240M
$5.55M 0.09%
+280,000
New +$6.51M
ARYD
90
DELISTED
ARYA Sciences Acquisition Corp IV Class A Odinary Shares
ARYD
$5.24M 0.08%
+500,000
New +$5.4M
PNT
91
DELISTED
POINT Biopharma Global Inc. Common Stock
PNT
$5.15M 0.08%
490,000
– –
BOLT icon
92
Bolt Biotherapeutics
BOLT
$7.78M
$4.94M 0.08%
+7,500
New +$4.88M
IMTX icon
93
Immatics
IMTX
$1.32B
$3.92M 0.06%
350,000
– –
FVAM
94
DELISTED
5:01 Acquisition Corp
FVAM
$3.9M 0.06%
392,000
– –
CHAQ.U
95
DELISTED
Chardan Healthcare Acquisition 2 Corp. Units, each consisting of one share of Common Stock, and one
CHAQ.U
$3.68M 0.06%
350,000
– –
PSNL icon
96
Personalis
PSNL
$1.51B
$3.14M 0.05%
127,501
– –
NUVB icon
97
Nuvation Bio
NUVB
$2.32B
$3.13M 0.05%
+300,000
New +$3.35M
MSACU
98
DELISTED
Medicus Sciences Acquisition Corp. Unit
MSACU
$2.96M 0.05%
+300,000
New +$3.05M
BDSX icon
99
Biodesix
BDSX
$248M
$2.54M 0.04%
6,250
– –
MRVI icon
100
Maravai LifeSciences
MRVI
$919M
$2.5M 0.04%
70,000
– –
1 2 3
4
5

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RTW Investments's Q1 2021 Portfolio in Review

As of Q1 2021, RTW Investments held 120 positions worth $6.41B, up 7.5% from $5.96B the previous quarter. Its ten largest holdings account for 43% of the portfolio.

RTW Investments deployed $949M of net new capital in Q1 2021, opening 18 new positions and adding to 32 existing holdings. Its largest new stake was State Street SPDR S&P 500 ETF Trust: 946,255 shares worth $375M.

By sector, the portfolio is most concentrated in Healthcare at 88% of assets, down from 94% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was Rocket Pharmaceuticals, an estimated $73.8M trimmed.

  • RTW Investments's largest Q1 2021 buy was State Street SPDR S&P 500 ETF Trust: 946,255 shares worth $375M.
  • RTW Investments added most to PTC Therapeutics in Q1 2021, an estimated $63.7M increase.
  • RTW Investments's biggest Q1 2021 reduction was Rocket Pharmaceuticals, cutting an estimated $73.8M.
  • RTW Investments fully exited Korro Bio in Q1 2021, selling an estimated $86.8M.
  • RTW Investments's ten largest holdings make up 43% of its $6.41B portfolio in Q1 2021.
  • RTW Investments opened 18 new positions and closed 9 in Q1 2021.
  • RTW Investments's portfolio value rose 7.5% quarter-over-quarter to $6.41B.

Based on RTW Investments's 13F filing for Q1 2021, filed 14 May 2021.