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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+4.01%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.54B
AUM Growth
-$74.4M
Cap. Flow
+$91.3M
Cap. Flow %
1.4%
Top 10 Hldgs %
52.67%
Holding
82
New
10
Increased
18
Reduced
7
Closed
14

Top Buys

Rank Stock Value
1
ISRG icon
Intuitive Surgical
ISRG
+$112M
2
BBNX
Beta Bionics
BBNX
+$61.5M
3
VRNA
Verona Pharma
VRNA
+$61.5M
4
QURE icon
uniQure
QURE
+$47.1M
5
GEHC icon
GE HealthCare
GEHC
+$44.7M

Top Sells

Rank Stock Value
1
BRKR icon
Bruker
BRKR
+$145M
2
AXSM icon
Axsome Therapeutics
AXSM
+$129M
3
DYN icon
Dyne Therapeutics
DYN
+$50.5M
4
ETNB
89bio
ETNB
+$48.2M
5
ALKS icon
Alkermes
ALKS
+$22M

Sector Composition

Rank Sector Weight
1 Healthcare 99.88%
2 Financials 0.12%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
GMED icon
26
Globus Medical
GMED
$11.2B
$82.3M 1.26%
1,125,000
+153,000
+16% +$12.6M
RARE icon
27
Ultragenyx Pharmaceutical
RARE
$2.55B
$61.8M 0.95%
1,707,402
-260,600
-13% -$10.8M
GHRS icon
28
GH Research
GHRS
$2.08B
$60.7M 0.93%
5,499,769
+2,172,640
+65% +$24.3M
SYRE icon
29
Spyre Therapeutics
SYRE
$9.25B
$58.4M 0.89%
3,621,996
– –
QURE icon
30
uniQure
QURE
$3.22B
$45.2M 0.69%
4,265,428
+3,361,803
+372% +$47.1M
URGN icon
31
UroGen Pharma
URGN
$2.29B
$42.4M 0.65%
3,834,794
– –
GEHC icon
32
GE HealthCare
GEHC
$32.4B
$42M 0.64%
+520,000
New +$44.7M
CGON icon
33
CG Oncology
CGON
$6.66B
$41.7M 0.64%
1,701,216
– –
BBNX
34
Beta Bionics
BBNX
$715M
$40.4M 0.62%
+3,299,870
New +$61.5M
OBIO icon
35
Orchestra BioMed
OBIO
$254M
$35.1M 0.54%
8,206,162
– –
STOK icon
36
Stoke Therapeutics
STOK
$2.11B
$34.1M 0.52%
5,123,525
– –
IMTX icon
37
Immatics
IMTX
$1.32B
$31.2M 0.48%
6,909,510
+368,970
+6% +$1.93M
TSHA icon
38
Taysha Gene Therapies
TSHA
$1.89B
$26.1M 0.4%
18,787,866
+10,115,236
+117% +$16.9M
VSTM icon
39
Verastem
VSTM
$610M
$25.6M 0.39%
+4,245,476
New +$25.9M
XNCR icon
40
Xencor
XNCR
$1.55B
$25.6M 0.39%
2,402,883
– –
ARVN icon
41
Arvinas
ARVN
$572M
$23.4M 0.36%
3,334,308
– –
LENZ
42
LENZ Therapeutics
LENZ
$168M
$22.2M 0.34%
863,389
– –
REPL icon
43
Replimune Group
REPL
$1.01B
$20.1M 0.31%
2,065,010
– –
ORKA
44
Oruka Therapeutics
ORKA
$5.96B
$20M 0.31%
1,945,649
– –
TEM
45
Tempus AI
TEM
$9.39B
$19.3M 0.3%
+400,000
New +$21.6M
GKOS icon
46
Glaukos
GKOS
$10.6B
$18.7M 0.29%
+190,000
New +$25.3M
DYN icon
47
Dyne Therapeutics
DYN
$4.9B
$17.7M 0.27%
1,690,567
-3,528,074
-68% -$50.5M
CRGX
48
DELISTED
CARGO Therapeutics
CRGX
$16.8M 0.26%
4,124,859
– –
DGX icon
49
Quest Diagnostics
DGX
$26.3B
$16.8M 0.26%
+98,997
New +$16.3M
CMPS
50
Compass Pathways
CMPS
$1.83B
$15.8M 0.24%
5,538,168
+2,439,181
+79% +$9.37M
1
2
3 4

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RTW Investments's Q1 2025 Portfolio in Review

As of Q1 2025, RTW Investments held 82 positions worth $6.54B, down 1.1% from $6.61B the previous quarter. Its ten largest holdings account for 53% of the portfolio.

RTW Investments's Q1 2025 filing shows 10 new, 18 increased, 7 reduced and 14 closed positions. Its largest new stake was Intuitive Surgical: 202,456 shares worth $100M. The largest sale was Bruker, an estimated $145M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q1 2025 buy was Intuitive Surgical: 202,456 shares worth $100M.
  • RTW Investments added most to Verona Pharma in Q1 2025, an estimated $61.5M increase.
  • RTW Investments's biggest Q1 2025 reduction was Axsome Therapeutics, cutting an estimated $129M.
  • RTW Investments fully exited Bruker in Q1 2025, selling an estimated $145M.
  • RTW Investments's ten largest holdings make up 53% of its $6.54B portfolio in Q1 2025.
  • RTW Investments opened 10 new positions and closed 14 in Q1 2025.
  • RTW Investments's portfolio value fell 1.1% quarter-over-quarter to $6.54B.

Based on RTW Investments's 13F filing for Q1 2025, filed 15 May 2025.