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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+5.22%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.61B
AUM Growth
-$298M
Cap. Flow
-$123M
Cap. Flow %
-1.86%
Top 10 Hldgs %
48.57%
Holding
77
New
9
Increased
21
Reduced
16
Closed
5

Top Buys

Rank Stock Value
1
GMED icon
Globus Medical
GMED
+$76.7M
2
SYK icon
Stryker
SYK
+$71.6M
3
ZLAB icon
Zai Lab
ZLAB
+$69.6M
4
VRNA
Verona Pharma
VRNA
+$68.4M
5
XNCR icon
Xencor
XNCR
+$42M

Top Sells

Rank Stock Value
1
GERN icon
Geron
GERN
+$200M
2
MASI
Masimo
MASI
+$123M
3
ACAD icon
Acadia Pharmaceuticals
ACAD
+$80.7M
4
BRKR icon
Bruker
BRKR
+$59.1M
5
GKOS icon
Glaukos
GKOS
+$50.3M

Sector Composition

Rank Sector Weight
1 Healthcare 99.89%
2 Financials 0.11%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SYRE icon
26
Spyre Therapeutics
SYRE
$9.25B
$84.3M 1.28%
3,621,996
+363,636
+11% +$10.7M
RARE icon
27
Ultragenyx Pharmaceutical
RARE
$2.55B
$82.8M 1.25%
1,968,002
– –
GMED icon
28
Globus Medical
GMED
$11.2B
$80.4M 1.22%
+972,000
New +$76.7M
ZLAB icon
29
Zai Lab
ZLAB
$2.62B
$65.7M 0.99%
+2,509,119
New +$69.6M
ARVN icon
30
Arvinas
ARVN
$572M
$63.9M 0.97%
3,334,308
+551,979
+20% +$13.4M
CRGX
31
DELISTED
CARGO Therapeutics
CRGX
$59.5M 0.9%
4,124,859
+25,904
+0.6% +$470K
ETNB
32
DELISTED
89bio
ETNB
$58.5M 0.88%
7,478,061
+99,513
+1% +$819K
STOK icon
33
Stoke Therapeutics
STOK
$2.11B
$56.5M 0.85%
5,123,525
+471,240
+10% +$5.79M
XNCR icon
34
Xencor
XNCR
$1.55B
$55.2M 0.84%
2,402,883
+1,827,883
+318% +$42M
CGON icon
35
CG Oncology
CGON
$6.66B
$48.8M 0.74%
1,701,216
+357,142
+27% +$12.2M
IMTX icon
36
Immatics
IMTX
$1.32B
$46.5M 0.7%
6,540,540
-3,459,460
-35% -$29.7M
URGN icon
37
UroGen Pharma
URGN
$2.29B
$40.8M 0.62%
3,834,794
+47,447
+1% +$568K
ORKA
38
Oruka Therapeutics
ORKA
$5.96B
$37.7M 0.57%
1,945,649
+95,001
+5% +$2.32M
OBIO icon
39
Orchestra BioMed
OBIO
$254M
$32.8M 0.5%
8,206,162
+3
+0% +$16
NGNE icon
40
Neurogene
NGNE
$712M
$30.9M 0.47%
1,350,256
+215,000
+19% +$8M
REPL icon
41
Replimune Group
REPL
$1.01B
$25M 0.38%
2,065,010
+931,223
+82% +$11.3M
LENZ
42
LENZ Therapeutics
LENZ
$168M
$24.9M 0.38%
863,389
– –
GHRS icon
43
GH Research
GHRS
$2.08B
$23.3M 0.35%
3,327,129
– –
CGEM icon
44
Cullinan Oncology
CGEM
$1.14B
$20.8M 0.31%
1,705,960
– –
RAPT
45
DELISTED
RAPT Therapeutics
RAPT
$18.6M 0.28%
+1,470,500
New +$18.7M
ROIV icon
46
Roivant Sciences
ROIV
$26.2B
$17.2M 0.26%
1,454,273
– –
SAGE
47
DELISTED
Sage Therapeutics
SAGE
$16.3M 0.25%
3,002,370
-2,589,330
-46% -$15.8M
QURE icon
48
uniQure
QURE
$3.22B
$16M 0.24%
903,625
+893,625
+8,936% +$7.71M
TSHA icon
49
Taysha Gene Therapies
TSHA
$1.89B
$15M 0.23%
8,672,630
-6,273,790
-42% -$13M
TRML
50
DELISTED
Tourmaline Bio
TRML
$14.9M 0.23%
736,681
-4,975
-0.7% -$125K
1
2
3 4

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RTW Investments's Q4 2024 Portfolio in Review

As of Q4 2024, RTW Investments held 77 positions worth $6.61B, down 4.3% from $6.91B the previous quarter. Its ten largest holdings account for 49% of the portfolio.

RTW Investments's Q4 2024 filing shows 9 new, 21 increased, 16 reduced and 5 closed positions. Its largest new stake was Globus Medical: 972,000 shares worth $80.4M. The largest sale was Geron, an estimated $200M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q4 2024 buy was Globus Medical: 972,000 shares worth $80.4M.
  • RTW Investments added most to Stryker in Q4 2024, an estimated $71.6M increase.
  • RTW Investments's biggest Q4 2024 reduction was Masimo, cutting an estimated $123M.
  • RTW Investments fully exited Geron in Q4 2024, selling an estimated $200M.
  • RTW Investments's ten largest holdings make up 49% of its $6.61B portfolio in Q4 2024.
  • RTW Investments opened 9 new positions and closed 5 in Q4 2024.
  • RTW Investments's portfolio value fell 4.3% quarter-over-quarter to $6.61B.

Based on RTW Investments's 13F filing for Q4 2024, filed 14 Feb 2025.