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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+18.13%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$4.9B
AUM Growth
+$561M
Cap. Flow
+$279M
Cap. Flow %
5.7%
Top 10 Hldgs %
55.22%
Holding
87
New
1
Increased
20
Reduced
10
Closed
10

Top Buys

Rank Stock Value
1
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$114M
2
AXSM icon
Axsome Therapeutics
AXSM
+$65.6M
3
RARE icon
Ultragenyx Pharmaceutical
RARE
+$63.2M
4
IMCR icon
Immunocore
IMCR
+$62.4M
5
RCKT icon
Rocket Pharmaceuticals
RCKT
+$34.7M

Top Sells

Rank Stock Value
1
ISEE
IVERIC bio, Inc. Common Stock
ISEE
+$59.8M
2
TSVT
2seventy bio
TSVT
+$17.9M
3
TNDM icon
Tandem Diabetes Care
TNDM
+$15.4M
4
GH icon
Guardant Health
GH
+$13.5M
5
RCOR
Renovacor, Inc.
RCOR
+$7.56M

Sector Composition

Rank Sector Weight
1 Healthcare 99.63%
2 Financials 0.27%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
AVDL
26
DELISTED
Avadel Pharmaceuticals
AVDL
$41.1M 0.84%
5,741,939
– –
PTGX icon
27
Protagonist Therapeutics
PTGX
$9.44B
$39.2M 0.8%
3,591,986
-584,851
-14% -$4.93M
ACET icon
28
Adicet Bio
ACET
$74.7M
$37.9M 0.77%
265,092
– –
PMVP icon
29
PMV Pharmaceuticals
PMVP
$63.5M
$37.9M 0.77%
4,356,920
– –
TARS icon
30
Tarsus Pharmaceuticals
TARS
$2.84B
$37.4M 0.76%
2,548,125
+524,946
+26% +$8.69M
BCYC
31
Bicycle Therapeutics
BCYC
$292M
$37.3M 0.76%
1,258,587
-17,689
-1% -$475K
FULC icon
32
Fulcrum Therapeutics
FULC
$297M
$36.4M 0.74%
4,993,279
+1,007,369
+25% +$6.57M
STOK icon
33
Stoke Therapeutics
STOK
$2.11B
$35.7M 0.73%
3,870,981
+219,158
+6% +$2.28M
TXG icon
34
10x Genomics
TXG
$6.61B
$31.8M 0.65%
872,592
+232,938
+36% +$7.62M
OYST
35
DELISTED
Oyster Point Pharma, Inc. Common Stock
OYST
$25.7M 0.53%
2,304,977
+260,665
+13% +$2.53M
OLK
36
DELISTED
Olink Holding AB (publ) American Depositary Shares
OLK
$24.9M 0.51%
981,918
– –
OM icon
37
Outset Medical
OM
$90.8M
$23.5M 0.48%
60,643
– –
GHRS icon
38
GH Research
GHRS
$2.08B
$21.1M 0.43%
2,168,957
– –
ISEE
39
DELISTED
IVERIC bio, Inc. Common Stock
ISEE
$17.6M 0.36%
821,288
-2,803,712
-77% -$59.8M
MIST icon
40
Milestone Pharmaceuticals
MIST
$152M
$17.1M 0.35%
4,315,102
– –
CINC
41
DELISTED
CinCor Pharma, Inc. Common Stock
CINC
$17.1M 0.35%
1,389,705
– –
CCCC icon
42
C4 Therapeutics
CCCC
$412M
$16.6M 0.34%
2,819,472
– –
ALLK
43
DELISTED
Allakos
ALLK
$13.8M 0.28%
1,643,500
– –
CSTL icon
44
Castle Biosciences
CSTL
$979M
$12.2M 0.25%
516,995
– –
GH icon
45
Guardant Health
GH
$22.6B
$11.7M 0.24%
430,887
-295,000
-41% -$13.5M
TERN
46
DELISTED
Terns Pharmaceuticals
TERN
$10.2M 0.21%
+1,000,000
New +$6.66M
OBIO icon
47
Orchestra BioMed
OBIO
$254M
$9.98M 0.2%
1,000,000
– –
WHWK
48
Whitehawk Therapeutics
WHWK
$271M
$9.81M 0.2%
764,701
– –
GLUE icon
49
Monte Rosa Therapeutics
GLUE
$1.35B
$9.24M 0.19%
1,214,572
– –
SGHT icon
50
Sight Sciences
SGHT
$412M
$8.12M 0.17%
665,323
– –
1
2
3 4

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RA
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GI
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IIM
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ACA
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VPIM
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HI
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MF
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RTW Investments's Q4 2022 Portfolio in Review

As of Q4 2022, RTW Investments held 87 positions worth $4.9B, up 13% from $4.34B the previous quarter. Its ten largest holdings account for 55% of the portfolio.

RTW Investments deployed $279M of net new capital in Q4 2022, opening 1 new position and adding to 20 existing holdings. Its largest new stake was Terns Pharmaceuticals: 1,000,000 shares worth $10.2M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 99% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was IVERIC bio, Inc. Common Stock, an estimated $59.8M trimmed.

  • RTW Investments's largest Q4 2022 buy was Terns Pharmaceuticals: 1,000,000 shares worth $10.2M.
  • RTW Investments added most to Mirati Therapeutics, Inc. Common Stock in Q4 2022, an estimated $114M increase.
  • RTW Investments's biggest Q4 2022 reduction was IVERIC bio, Inc. Common Stock, cutting an estimated $59.8M.
  • RTW Investments fully exited 2seventy bio in Q4 2022, selling an estimated $17.9M.
  • RTW Investments's ten largest holdings make up 55% of its $4.9B portfolio in Q4 2022.
  • RTW Investments opened 1 new position and closed 10 in Q4 2022.
  • RTW Investments's portfolio value rose 13% quarter-over-quarter to $4.9B.

Based on RTW Investments's 13F filing for Q4 2022, filed 14 Feb 2023.