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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+2.62%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.41B
AUM Growth
+$445M
Cap. Flow
+$949M
Cap. Flow %
14.82%
Top 10 Hldgs %
42.9%
Holding
120
New
18
Increased
32
Reduced
16
Closed
9

Top Buys

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$365M
2
QDEL icon
QuidelOrtho
QDEL
+$162M
3
RXDX
Prometheus Biosciences, Inc. Common Stock
RXDX
+$67.4M
4
PTCT icon
PTC Therapeutics
PTCT
+$63.7M
5
ITOS
iTeos Therapeutics
ITOS
+$61M

Top Sells

Rank Stock Value
1
KRRO icon
Korro Bio
KRRO
+$86.8M
2
RCKT icon
Rocket Pharmaceuticals
RCKT
+$73.8M
3
FPRX
Five Prime Therapeutics, Inc.
FPRX
+$42.8M
4
IMVT icon
Immunovant
IMVT
+$32.6M
5
PEN icon
Penumbra
PEN
+$20.7M

Sector Composition

Rank Sector Weight
1 Healthcare 88.33%
2 Financials 0.35%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
RNAM
26
DELISTED
Avidity Biosciences
RNAM
$87.1M 1.36%
3,995,000
– –
CLDX icon
27
Celldex Therapeutics
CLDX
$3.28B
$80.5M 1.26%
3,908,947
+486,092
+14% +$11.2M
CCCC icon
28
C4 Therapeutics
CCCC
$412M
$79.4M 1.24%
2,149,228
– –
TARS icon
29
Tarsus Pharmaceuticals
TARS
$2.84B
$79.1M 1.23%
2,463,601
– –
ADVM
30
DELISTED
Adverum Biotechnologies
ADVM
$72.5M 1.13%
734,898
+12,162
+2% +$1.46M
TBIO
31
DELISTED
Translate Bio, Inc. Common Stock
TBIO
$72.3M 1.13%
4,382,199
+1,403,772
+47% +$32M
MGNX icon
32
MacroGenics
MGNX
$257M
$64.2M 1%
2,014,400
+757,991
+60% +$18.4M
IDYA icon
33
IDEAYA Biosciences
IDYA
$3.56B
$58M 0.9%
2,466,255
+619,412
+34% +$12M
CSTL icon
34
Castle Biosciences
CSTL
$979M
$54.7M 0.85%
799,009
– –
RLMD icon
35
Relmada Therapeutics
RLMD
$527M
$53.9M 0.84%
1,530,717
+18,044
+1% +$631K
NSTG
36
DELISTED
NanoString Technologies, Inc.
NSTG
$52.8M 0.82%
804,029
– –
AVDL
37
DELISTED
Avadel Pharmaceuticals
AVDL
$51.9M 0.81%
5,741,939
+354,426
+7% +$2.87M
RXDX
38
DELISTED
Prometheus Biosciences, Inc. Common Stock
RXDX
$51.7M 0.81%
+3,264,031
New +$67.4M
LUNG icon
39
Pulmonx
LUNG
$87.6M
$51.7M 0.81%
1,129,600
– –
IMCR icon
40
Immunocore
IMCR
$1.73B
$50.1M 0.78%
+1,245,532
New +$55.5M
LONA
41
LeonaBio Inc
LONA
$72.1M
$48.8M 0.76%
265,255
-3,323
-1% -$733K
CYTK icon
42
Cytokinetics
CYTK
$10.4B
$46.5M 0.73%
2,000,000
– –
PRQR icon
43
ProQR Therapeutics
PRQR
$265M
$42.5M 0.66%
6,424,078
+1,414,310
+28% +$7.23M
ISEE
44
DELISTED
IVERIC bio, Inc. Common Stock
ISEE
$41.5M 0.65%
6,722,624
– –
CRIS icon
45
Curis
CRIS
$7.83M
$41M 0.64%
9,049
-269
-3% -$1.13M
GTH
46
DELISTED
Genetron Holdings Limited ADS
GTH
$39M 0.61%
+606,054
New +$41.6M
LABP
47
DELISTED
Landos Biopharma, Inc. Common Stock
LABP
$38.3M 0.6%
+427,572
New +$55.8M
FULC icon
48
Fulcrum Therapeutics
FULC
$297M
$37.8M 0.59%
3,205,291
+1,133,882
+55% +$14M
AGEN
49
Agenus
AGEN
$290M
$37.5M 0.59%
701,951
+46,496
+7% +$3.36M
OM icon
50
Outset Medical
OM
$90.8M
$37.4M 0.58%
45,810
+6,805
+17% +$5.25M
1
2
3 4 5

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RTW Investments's Q1 2021 Portfolio in Review

As of Q1 2021, RTW Investments held 120 positions worth $6.41B, up 7.5% from $5.96B the previous quarter. Its ten largest holdings account for 43% of the portfolio.

RTW Investments deployed $949M of net new capital in Q1 2021, opening 18 new positions and adding to 32 existing holdings. Its largest new stake was State Street SPDR S&P 500 ETF Trust: 946,255 shares worth $375M.

By sector, the portfolio is most concentrated in Healthcare at 88% of assets, down from 94% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was Rocket Pharmaceuticals, an estimated $73.8M trimmed.

  • RTW Investments's largest Q1 2021 buy was State Street SPDR S&P 500 ETF Trust: 946,255 shares worth $375M.
  • RTW Investments added most to PTC Therapeutics in Q1 2021, an estimated $63.7M increase.
  • RTW Investments's biggest Q1 2021 reduction was Rocket Pharmaceuticals, cutting an estimated $73.8M.
  • RTW Investments fully exited Korro Bio in Q1 2021, selling an estimated $86.8M.
  • RTW Investments's ten largest holdings make up 43% of its $6.41B portfolio in Q1 2021.
  • RTW Investments opened 18 new positions and closed 9 in Q1 2021.
  • RTW Investments's portfolio value rose 7.5% quarter-over-quarter to $6.41B.

Based on RTW Investments's 13F filing for Q1 2021, filed 14 May 2021.