RTW Investments Portfolio holdings

AUM $7.02B

2025 Q2 2025 Q1 2024 Q4 2024 Q3 2024 Q2 2024 Q1 2023 Q4 2023 Q3 2023 Q2 2023 Q1 2022 Q4 2022 Q3 2022 Q2 2022 Q1 2021 Q4 2021 Q3 2021 Q2 2021 Q1 2020 Q4 2020 Q3 2020 Q2 2020 Q1 2019 Q4 2019 Q3 2019 Q2 2019 Q1 2018 Q4 2018 Q3 2018 Q2 2018 Q1 2017 Q4 2017 Q3 2017 Q2 2017 Q1 2016 Q4 2016 Q3 2016 Q2 2016 Q1 2015 Q4 2015 Q3 2015 Q2 2015 Q1 2014 Q4

This Quarter Return

-17.95%

1 Year Return

+28.16%

3 Year Return

+245.48%

5 Year Return

+425.65%

10 Year Return

+5,642.23%

AUM

$319M

AUM Growth

+$319M (-5.4%)

Cap. Flow

+$54.6M

Cap. Flow % of AUM

17.13%

Top 10 Holdings % Top 10 Hldgs %

71.74%

Holding

New

Increased

Reduced

Closed

Top Buys

1	LJPC La Jolla Pharmaceutical Company LJPC	$22.1M
2	MRTX Mirati Therapeutics, Inc. Common Stock MRTX	$16.6M
3	Incyte INCY	$11.9M
4	Alnylam Pharmaceuticals ALNY	$9.86M
5	Atara Biotherapeutics ATRA	$8.27M

Top Sells

1	Gyre Therapeutics GYRE	$10.7M
2	DYAX DYAX CORPORATION DYAX	$8.47M
3	iShares 20+ Year Treasury Bond ETF TLT	$3.88M
4	United States Oil Fund USO	$3.28M
5	Arrowhead Research ARWR	$2.67M

Sector Composition

1	Healthcare	84.83%
2	Financials	0%

Communication Services

Advertising Agencies

Broadcasting

Electronic Gaming & Multimedia

Entertainment

Internet Content & Information

Publishing

Telecom Services

Consumer Discretionary

Apparel Manufacturing

Apparel Retail

Auto Manufacturers

Auto Parts

Auto & Truck Dealerships

Department Stores

Footwear & Accessories

Furnishings, Fixtures & Appliances

Gambling

Home Improvement Retail

Internet Retail

Leisure

Lodging

Luxury Goods

Packaging & Containers

Personal Services

Recreational Vehicles

Residential Construction

Resorts & Casinos

Restaurants

Specialty Retail

Textile Manufacturing

Travel Services

Consumer Staples

Beverages - Brewers

Beverages - Non-Alcoholic

Beverages - Wineries & Distilleries

Confectioners

Discount Stores

Education & Training Services

Farm Products

Food Distribution

Grocery Stores

Household & Personal Products

Packaged Foods

Tobacco

Energy

Oil & Gas Drilling

Oil & Gas Equipment & Services

Oil & Gas Exploration & Production

Oil & Gas Integrated

Oil & Gas Midstream

Oil & Gas Refining & Marketing

Thermal Coal

Uranium

Financials

Asset Management

Banks - Diversified

Banks - Regional

Capital Markets

Credit Services

Diversified Insurance

Financial Conglomerates

Financial Data & Stock Exchanges

Insurance Brokers

Life Insurance

Mortgage Finance

Property & Casualty Insurance

Reinsurance

Shell Companies

Specialty - Insurance

Healthcare

Biotechnology

Diagnostics & Research

Drug Manufacturers - General

Drug Manufacturers - Specialty & Generic

Healthcare Plans

Health Information Services

Medical Care Facilities

Medical Devices

Medical Distribution

Medical Instruments & Supplies

Pharmaceutical Retailers

Industrials

Aerospace & Defense

Airlines

Airports & Air Services

Building Products & Equipment

Business Equipment & Supplies

Conglomerates

Consulting Services

Electrical Equipment & Parts

Engineering & Construction

Farm & Heavy Construction Machinery

Industrial Distribution

Infrastructure Operations

Integrated Freight & Logistics

Marine Shipping

Metal Fabrication

Pollution & Treatment Controls

Railroads

Rental & Leasing Services

Security & Protection Services

Specialty Business Services

Specialty Industrial Machinery

Staffing & Employment Services

Tools & Accessories

Trucking

Waste Management

Materials

Agricultural Inputs

Aluminum

Building Materials

Chemicals

Coking Coal

Copper

Gold

Lumber & Wood Production

Other Industrial Metals & Mining

Other Precious Metals & Mining

Paper & Paper Products

Silver

Specialty Chemicals

Steel

Real Estate

Diversified REIT

Healthcare Facilities REIT

Hotel & Motel REIT

Industrial REIT

Mortgage REIT

Office REIT

Real Estate Development

Real Estate Diversified

Real Estate Services

Residential REIT

Retail REIT

Specialty REIT

Technology

Communication Equipment

Computer Hardware

Consumer Electronics

Electronic Components

Electronics & Computer Distribution

Information Technology Services

Scientific & Technical Instruments

Semiconductor Equipment & Materials

Semiconductors

Software - Application

Software - Infrastructure

Solar

Utilities

Diversified Utilities

Electric Utilities

Gas Utilities

Independent Power Producers

Renewable Electricity

Water Utilities

#	Name	Market Value	Portfolio Weight	Shares or Principal	Shares Change %	Capital Flow
26	RPRX 26 DELISTED Repros Therapeutics Inc. RPRX	$1.73M	0.54%	232,830 +3,466	+2%	+$25.8K
27	VBIV 27 DELISTED VBI Vaccines, Inc. New Common Stock (Canada) VBIV	$1.72M	0.53%	+650,000	New	+$1.72M
28	28 OraSure Technologies OSUR $242M	$1.43M	0.45%	+322,996	New	+$1.43M
29	LUMO 29 DELISTED Lumos Pharma, Inc. Common Stock LUMO	$1.01M	0.32%	28,291 -71,709	-72%	-$2.57M
30	30 Masimo MASI $7.59B	$999K	0.31%	+25,900	New	+$999K
31	MDRX 31 DELISTED Veradigm Inc. Common Stock MDRX	$595K	0.18%	+48,000	New	+$595K
32	ALPN 32 DELISTED Alpine Immune Sciences, Inc. Common Stock ALPN	$389K	0.12%	30,000	–	–
33	TMBR 33 DELISTED Timber Pharmaceuticals, Inc. TMBR	$382K	0.12%	370,636	–	–
34	34 Natera NTRA $23.1B	$344K	0.11%	+31,693	New	+$344K
35	GHDX 35 DELISTED Genomic Health, Inc. GHDX	$317K	0.1%	+15,000	New	+$317K
36	ELGX 36 DELISTED Endologix Inc ELGX	$184K	0.06%	+15,000	New	+$184K
37	37 Veracyte VCYT $2.39B	$117K	0.04%	+25,000	New	+$117K
38	ADAP 38 Adaptimmune Therapeutics ADAP $15.6M	$84K	0.03%	7,028 -12,972	-65%	-$155K
39	39 Berkshire Hathaway Class B BRK.B $1.09T	$7K	﹤0.01%	50	–	–
40	40 Bausch Health BHC $2.74B	–	–	0	–	–
41	41 Fortress Biotech FBIO $76.8M	–	–	-11,917	Closed	-$40K
42	42 iShares 20+ Year Treasury Bond ETF TLT $47.8B	–	–	-33,000	Closed	-$3.88M
43	43 United States Oil Fund USO $967M	–	–	-165,000	Closed	-$3.28M
44	VIVO 44 DELISTED Meridian Bioscience Inc VIVO	–	–	0	–	–
45	ZGNX 45 DELISTED Zogenix, Inc. ZGNX	–	–	-114,128	Closed	-$192K