Jane Street
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Jane Street’s Krystal Biotech KRYS Stock Holding History

Jane Street’s Portfolio KRYS Stock Details KRYS Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$1.89M Sell
7,300
-16,500
-69% -$4.39M ﹤0.01% 5212
2025
Q4 		$5.87M Sell
23,800
-32,000
-57% -$6.74M ﹤0.01% 2992
2025
Q3 		$9.85M Buy
55,800
+2,000
+4% +$299K ﹤0.01% 2444
2025
Q2 		$7.4M Buy
53,800
+48,800
+976% +$7.17M ﹤0.01% 2516
2025
Q1 		$902K Buy
5,000
+1,800
+56% +$303K ﹤0.01% 5759
2024
Q4 		$501K Sell
3,200
-51,500
-94% -$9.14M ﹤0.01% 6781
2024
Q3 		$9.96M Buy
54,700
+600
+1% +$116K ﹤0.01% 1915
2024
Q2 		$9.93M Sell
54,100
-4,300
-7% -$722K ﹤0.01% 2056
2024
Q1 		$10.4M Buy
58,400
+3,500
+6% +$486K ﹤0.01% 1769
2023
Q4 		$6.81M Sell
54,900
-7,800
-12% -$865K ﹤0.01% 2427
2023
Q3 		$7.27M Buy
62,700
+36,600
+140% +$4.47M ﹤0.01% 2140
2023
Q2 		$3.06M Buy
+26,100
New +$2.66M ﹤0.01% 3458
2022
Q3 		– Sell
-4,200
Closed -$276K – 10100
2022
Q2 		$276K Sell
4,200
-1,100
-21% -$68.4K ﹤0.01% 7746
2022
Q1 		$353K Sell
5,300
-54,300
-91% -$3.39M ﹤0.01% 8120
2021
Q4 		$4.17M Buy
+59,600
New +$3.47M ﹤0.01% 3134

Other funds holding KRYS

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
SCM
Soleus Capital Management Greenwich, Connecticut $2.47B AUM 115.63% 1-Year Est. Return
Capital World Investors
Capital World Investors Los Angeles, California $733B AUM 35.63% 1-Year Est. Return
RG
Redmile Group San Francisco, California $1.51B AUM 164.17% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

Jane Street's KRYS Position: Q4 2025 in Review

Jane Street sold out of Krystal Biotech (KRYS) in Q4 2025, closing a stake of 3,381 shares — an estimated $712K sold.

Jane Street first reported a position in KRYS in Q3 2019 and held it in 15 quarters. The position peaked at $16.7M in Q1 2024. 334 funds tracked by Wall St. Rank hold KRYS as of Q4 2025.

  • Jane Street reported no remaining Krystal Biotech position as of Q4 2025 after selling out during the quarter.
  • Jane Street sold 3,381 Krystal Biotech shares in Q4 2025, an estimated $712K.
  • Jane Street first reported a position in Krystal Biotech in Q3 2019 and held it in 15 quarters.
  • Jane Street's Krystal Biotech position peaked at $16.7M in Q1 2024.
  • 334 funds tracked by Wall St. Rank held Krystal Biotech as of Q4 2025.

Based on Jane Street's 13F filing for Q4 2025, filed 12 Feb 2026.