Jane Street
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Jane Street’s Krystal Biotech KRYS Stock Holding History

Jane Street’s Portfolio KRYS Stock Details KRYS Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-3,381
Closed -$712K – 11819
2025
Q3 		$597K Buy
+3,381
New +$506K ﹤0.01% 7465
2025
Q2 		– Sell
-23,663
Closed -$3.48M – 10311
2025
Q1 		$4.27M Sell
23,663
-12,192
-34% -$2.05M ﹤0.01% 3170
2024
Q4 		$5.62M Buy
35,855
+17,674
+97% +$3.14M ﹤0.01% 2513
2024
Q3 		$3.31M Sell
18,181
-59,651
-77% -$11.5M ﹤0.01% 3541
2024
Q2 		$14.3M Sell
77,832
-15,913
-17% -$2.67M ﹤0.01% 1634
2024
Q1 		$16.7M Buy
93,745
+43,127
+85% +$5.99M ﹤0.01% 1335
2023
Q4 		$6.28M Sell
50,618
-24,508
-33% -$2.72M ﹤0.01% 2538
2023
Q3 		$8.71M Buy
75,126
+58,071
+340% +$7.08M ﹤0.01% 1937
2023
Q2 		$2M Sell
17,055
-7,051
-29% -$720K ﹤0.01% 4162
2023
Q1 		$1.93M Buy
+24,106
New +$1.89M ﹤0.01% 3889
2022
Q3 		– Sell
-4,509
Closed -$326K – 10099
2022
Q2 		$296K Sell
4,509
-15,818
-78% -$984K ﹤0.01% 7626
2022
Q1 		$1.35M Sell
20,327
-7,357
-27% -$459K ﹤0.01% 5490
2021
Q4 		$1.94M Buy
+27,684
New +$1.61M ﹤0.01% 4558
2021
Q1 		– Sell
-10,406
Closed -$624K – 9377
2020
Q4 		$624K Buy
+10,406
New +$520K ﹤0.01% 5409
2019
Q4 		– Sell
-6,939
Closed -$241K – 5449
2019
Q3 		$241K Buy
+6,939
New +$310K ﹤0.01% 4428

Other funds holding KRYS

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
SCM
Soleus Capital Management Greenwich, Connecticut $2.47B AUM 115.63% 1-Year Est. Return
Capital World Investors
Capital World Investors Los Angeles, California $733B AUM 35.63% 1-Year Est. Return
RG
Redmile Group San Francisco, California $1.51B AUM 164.17% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

Jane Street's KRYS Position: Q4 2025 in Review

Jane Street sold out of Krystal Biotech (KRYS) in Q4 2025, closing a stake of 3,381 shares — an estimated $712K sold.

Jane Street first reported a position in KRYS in Q3 2019 and held it in 15 quarters. The position peaked at $16.7M in Q1 2024. 334 funds tracked by Wall St. Rank hold KRYS as of Q4 2025.

  • Jane Street reported no remaining Krystal Biotech position as of Q4 2025 after selling out during the quarter.
  • Jane Street sold 3,381 Krystal Biotech shares in Q4 2025, an estimated $712K.
  • Jane Street first reported a position in Krystal Biotech in Q3 2019 and held it in 15 quarters.
  • Jane Street's Krystal Biotech position peaked at $16.7M in Q1 2024.
  • 334 funds tracked by Wall St. Rank held Krystal Biotech as of Q4 2025.

Based on Jane Street's 13F filing for Q4 2025, filed 12 Feb 2026.