Jane Street
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Jane Street’s Krystal Biotech KRYS Stock Holding History

Jane Street’s Portfolio KRYS Stock Details KRYS Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$4.78M Sell
18,500
-11,900
-39% -$3.17M ﹤0.01% 3586
2025
Q4 		$7.49M Buy
30,400
+22,800
+300% +$4.8M ﹤0.01% 2683
2025
Q3 		$1.34M Sell
7,600
-57,900
-88% -$8.67M ﹤0.01% 5706
2025
Q2 		$9M Buy
65,500
+60,800
+1,294% +$8.93M ﹤0.01% 2267
2025
Q1 		$847K Sell
4,700
-21,600
-82% -$3.63M ﹤0.01% 5881
2024
Q4 		$4.12M Sell
26,300
-13,200
-33% -$2.34M ﹤0.01% 2936
2024
Q3 		$7.19M Buy
39,500
+13,300
+51% +$2.56M ﹤0.01% 2315
2024
Q2 		$4.81M Sell
26,200
-110,400
-81% -$18.5M ﹤0.01% 3019
2024
Q1 		$24.3M Buy
136,600
+67,200
+97% +$9.33M 0.01% 1048
2023
Q4 		$8.61M Buy
69,400
+58,600
+543% +$6.5M ﹤0.01% 2129
2023
Q3 		$1.25M Sell
10,800
-26,000
-71% -$3.17M ﹤0.01% 4830
2023
Q2 		$4.32M Buy
36,800
+15,900
+76% +$1.62M ﹤0.01% 2954
2023
Q1 		$1.67M Buy
+20,900
New +$1.64M ﹤0.01% 4136
2022
Q4 		– Sell
-8,800
Closed -$613K – 9659
2022
Q3 		$613K Buy
8,800
+2,800
+47% +$202K ﹤0.01% 6308
2022
Q2 		$394K Sell
6,000
-10,100
-63% -$628K ﹤0.01% 7158
2022
Q1 		$1.07M Buy
16,100
+3,500
+28% +$218K ﹤0.01% 5998
2021
Q4 		$881K Sell
12,600
-21,800
-63% -$1.27M ﹤0.01% 6158
2021
Q3 		$1.8M Buy
+34,400
New +$2.04M ﹤0.01% 4699
2020
Q3 		– Sell
-9,900
Closed -$410K – 7565
2020
Q2 		$410K Buy
+9,900
New +$476K ﹤0.01% 5376

Other funds holding KRYS

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
SCM
Soleus Capital Management Greenwich, Connecticut $2.47B AUM 115.63% 1-Year Est. Return
Capital World Investors
Capital World Investors Los Angeles, California $733B AUM 35.63% 1-Year Est. Return
RG
Redmile Group San Francisco, California $1.51B AUM 164.17% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

Jane Street's KRYS Position: Q4 2025 in Review

Jane Street sold out of Krystal Biotech (KRYS) in Q4 2025, closing a stake of 3,381 shares — an estimated $712K sold.

Jane Street first reported a position in KRYS in Q3 2019 and held it in 15 quarters. The position peaked at $16.7M in Q1 2024. 334 funds tracked by Wall St. Rank hold KRYS as of Q4 2025.

  • Jane Street reported no remaining Krystal Biotech position as of Q4 2025 after selling out during the quarter.
  • Jane Street sold 3,381 Krystal Biotech shares in Q4 2025, an estimated $712K.
  • Jane Street first reported a position in Krystal Biotech in Q3 2019 and held it in 15 quarters.
  • Jane Street's Krystal Biotech position peaked at $16.7M in Q1 2024.
  • 334 funds tracked by Wall St. Rank held Krystal Biotech as of Q4 2025.

Based on Jane Street's 13F filing for Q4 2025, filed 12 Feb 2026.