Jane Street
BPMC

Jane Street’s Blueprint Medicines BPMC Stock Holding History

Jane Street’s Portfolio BPMC Stock Details BPMC Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q3 		– Sell
-583,000
Closed -$74.7M – 10813
2025
Q2 		$74.7M Sell
583,000
-124,100
-18% -$12.9M 0.01% 573
2025
Q1 		$62.6M Sell
707,100
-243,000
-26% -$23.7M 0.02% 548
2024
Q4 		$82.9M Buy
950,100
+386,700
+69% +$35.4M 0.02% 497
2024
Q3 		$52.1M Sell
563,400
-45,100
-7% -$4.48M 0.01% 678
2024
Q2 		$65.6M Buy
608,500
+416,400
+217% +$41.7M 0.02% 567
2024
Q1 		$18.2M Buy
192,100
+8,700
+5% +$746K ﹤0.01% 1267
2023
Q4 		$16.9M Buy
183,400
+36,200
+25% +$2.35M ﹤0.01% 1418
2023
Q3 		$7.39M Buy
147,200
+73,700
+100% +$3.94M ﹤0.01% 2114
2023
Q2 		$4.65M Sell
73,500
-14,500
-16% -$788K ﹤0.01% 2851
2023
Q1 		$3.96M Sell
88,000
-14,800
-14% -$667K ﹤0.01% 2769
2022
Q4 		$4.5M Buy
102,800
+45,700
+80% +$2.19M ﹤0.01% 2633
2022
Q3 		$3.76M Buy
57,100
+43,900
+333% +$2.82M ﹤0.01% 3079
2022
Q2 		$667K Sell
13,200
-9,000
-41% -$527K ﹤0.01% 6211
2022
Q1 		$1.42M Sell
22,200
-6,500
-23% -$467K ﹤0.01% 5405
2021
Q4 		$3.07M Sell
28,700
-3,200
-10% -$335K ﹤0.01% 3640
2021
Q3 		$3.28M Sell
31,900
-200
-0.6% -$18.6K ﹤0.01% 3493
2021
Q2 		$2.82M Buy
32,100
+28,800
+873% +$2.64M ﹤0.01% 3673
2021
Q1 		$321K Sell
3,300
-31,800
-91% -$3.17M ﹤0.01% 7593
2020
Q4 		$3.94M Buy
35,100
+9,900
+39% +$1.04M ﹤0.01% 2429
2020
Q3 		$2.34M Sell
25,200
-4,500
-15% -$347K ﹤0.01% 2800
2020
Q2 		$2.32M Buy
+29,700
New +$2.01M ﹤0.01% 2857

Other funds holding BPMC

DekaBank Deutsche Girozentrale
DekaBank Deutsche Girozentrale Frankfurt, Germany $60.6B AUM 23.27% 1-Year Est. Return
VanEck Associates
VanEck Associates New York $133B AUM 72.99% 1-Year Est. Return
IA
IFP Advisors Tampa, Florida $5.54B AUM 27.43% 1-Year Est. Return
Osaic Holdings
Osaic Holdings Scottsdale, Arizona $68.3B AUM 20.5% 1-Year Est. Return
HNB
Huntington National Bank Columbus, Ohio $18.1B AUM 24.69% 1-Year Est. Return

Jane Street's BPMC Position: Q3 2025 in Review

Jane Street sold out of Blueprint Medicines (BPMC) in Q3 2025, closing a stake of 214,394 shares — an estimated $27.5M sold.

Jane Street first reported a position in BPMC in Q1 2017 and held it in 28 quarters. The position peaked at $35.6M in Q4 2024. 5 funds tracked by Wall St. Rank hold BPMC as of Q3 2025.

  • Jane Street reported no remaining Blueprint Medicines position as of Q3 2025 after selling out during the quarter.
  • Jane Street sold 214,394 Blueprint Medicines shares in Q3 2025, an estimated $27.5M.
  • Jane Street first reported a position in Blueprint Medicines in Q1 2017 and held it in 28 quarters.
  • Jane Street's Blueprint Medicines position peaked at $35.6M in Q4 2024.
  • 5 funds tracked by Wall St. Rank held Blueprint Medicines as of Q3 2025.

Based on Jane Street's 13F filing for Q3 2025, filed 14 Nov 2025.