Jane Street
BPMC

Jane Street’s Blueprint Medicines BPMC Stock Holding History

Jane Street’s Portfolio BPMC Stock Details BPMC Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q3 		– Sell
-580,600
Closed -$74.4M – 10811
2025
Q2 		$74.4M Sell
580,600
-146,600
-20% -$15.2M 0.01% 576
2025
Q1 		$64.4M Sell
727,200
-49,600
-6% -$4.84M 0.02% 533
2024
Q4 		$67.8M Sell
776,800
-604,700
-44% -$55.4M 0.01% 567
2024
Q3 		$128M Sell
1,381,500
-78,800
-5% -$7.83M 0.03% 321
2024
Q2 		$157M Buy
1,460,300
+847,400
+138% +$84.8M 0.04% 260
2024
Q1 		$58.1M Buy
612,900
+81,800
+15% +$7.02M 0.01% 562
2023
Q4 		$49M Buy
531,100
+463,500
+686% +$30M 0.01% 689
2023
Q3 		$3.39M Buy
67,600
+7,400
+12% +$395K ﹤0.01% 3181
2023
Q2 		$3.8M Sell
60,200
-86,700
-59% -$4.71M ﹤0.01% 3133
2023
Q1 		$6.61M Buy
146,900
+48,200
+49% +$2.17M ﹤0.01% 2089
2022
Q4 		$4.32M Sell
98,700
-7,600
-7% -$364K ﹤0.01% 2677
2022
Q3 		$7M Buy
106,300
+61,200
+136% +$3.93M ﹤0.01% 2126
2022
Q2 		$2.28M Buy
45,100
+22,700
+101% +$1.33M ﹤0.01% 3914
2022
Q1 		$1.43M Buy
22,400
+18,100
+421% +$1.3M ﹤0.01% 5389
2021
Q4 		$461K Buy
4,300
+1,500
+54% +$157K ﹤0.01% 7425
2021
Q3 		$288K Sell
2,800
-24,900
-90% -$2.32M ﹤0.01% 8266
2021
Q2 		$2.44M Buy
27,700
+3,900
+16% +$357K ﹤0.01% 3946
2021
Q1 		$2.31M Sell
23,800
-1,200
-5% -$120K ﹤0.01% 3742
2020
Q4 		$2.8M Buy
25,000
+7,200
+40% +$759K ﹤0.01% 2909
2020
Q3 		$1.65M Sell
17,800
-28,900
-62% -$2.23M ﹤0.01% 3327
2020
Q2 		$3.64M Buy
46,700
+22,900
+96% +$1.55M ﹤0.01% 2240
2020
Q1 		$1.39M Buy
+23,800
New +$1.53M ﹤0.01% 2410

Other funds holding BPMC

DekaBank Deutsche Girozentrale
DekaBank Deutsche Girozentrale Frankfurt, Germany $60.6B AUM 23.27% 1-Year Est. Return
VanEck Associates
VanEck Associates New York $133B AUM 72.99% 1-Year Est. Return
IA
IFP Advisors Tampa, Florida $5.54B AUM 27.43% 1-Year Est. Return
Osaic Holdings
Osaic Holdings Scottsdale, Arizona $68.3B AUM 20.5% 1-Year Est. Return
HNB
Huntington National Bank Columbus, Ohio $18.1B AUM 24.69% 1-Year Est. Return

Jane Street's BPMC Position: Q3 2025 in Review

Jane Street sold out of Blueprint Medicines (BPMC) in Q3 2025, closing a stake of 214,394 shares — an estimated $27.5M sold.

Jane Street first reported a position in BPMC in Q1 2017 and held it in 28 quarters. The position peaked at $35.6M in Q4 2024. 5 funds tracked by Wall St. Rank hold BPMC as of Q3 2025.

  • Jane Street reported no remaining Blueprint Medicines position as of Q3 2025 after selling out during the quarter.
  • Jane Street sold 214,394 Blueprint Medicines shares in Q3 2025, an estimated $27.5M.
  • Jane Street first reported a position in Blueprint Medicines in Q1 2017 and held it in 28 quarters.
  • Jane Street's Blueprint Medicines position peaked at $35.6M in Q4 2024.
  • 5 funds tracked by Wall St. Rank held Blueprint Medicines as of Q3 2025.

Based on Jane Street's 13F filing for Q3 2025, filed 14 Nov 2025.