FLSM

Frazier Life Sciences Management Portfolio holdings

AUM $2.5B
1-Year Return 52.94%
This Quarter Return
+30.23%
1 Year Return
+52.94%
3 Year Return
+530.54%
5 Year Return
–
10 Year Return
–
AUM
$1.87B
AUM Growth
+$366M
Cap. Flow
+$70.6M
Cap. Flow %
3.78%
Top 10 Hldgs %
59.4%
Holding
56
New
5
Increased
14
Reduced
4
Closed
7

Top Buys

1
ETNB icon
89bio
ETNB
$22.3M
2
EWTX icon
Edgewise Therapeutics
EWTX
$19.9M
3
APLS icon
Apellis Pharmaceuticals
APLS
$16.2M
4
MDGL icon
Madrigal Pharmaceuticals
MDGL
$16.1M
5
DYN icon
Dyne Therapeutics
DYN
$15.8M

Top Sells

1
CRNX icon
Crinetics Pharmaceuticals
CRNX
$42.4M
2
ELVN icon
Enliven Therapeutics
ELVN
$14.3M
3
SNDX icon
Syndax Pharmaceuticals
SNDX
$8.71M
4
REPL icon
Replimune Group
REPL
$6.62M
5
PRTA icon
Prothena Corp
PRTA
$6.17M

Sector Composition

1 Healthcare 99.92%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
ORIC icon
26
Oric Pharmaceuticals
ORIC
$1.03B
$19.7M 1.05%
2,142,855
– –
ANAB icon
27
AnaptysBio
ANAB
$589M
$19.3M 1.03%
899,700
– –
SVRA icon
28
Savara
SVRA
$601M
$18.8M 1.01%
4,000,000
– –
SLNO icon
29
Soleno Therapeutics
SLNO
$3.67B
$18.7M 1%
464,937
– –
CERE
30
DELISTED
Cerevel Therapeutics Holdings, Inc. Common Stock
CERE
$16.7M 0.89%
393,000
– –
DCPH
31
DELISTED
Deciphera Pharmaceuticals, Inc. Common Stock
DCPH
$16.5M 0.88%
1,021,800
+651,800
+176% +$10.5M
MDGL icon
32
Madrigal Pharmaceuticals
MDGL
$9.55B
$16.1M 0.86%
+69,406
New +$16.1M
DYN icon
33
Dyne Therapeutics
DYN
$1.87B
$15.8M 0.84%
+1,184,840
New +$15.8M
SLN
34
Silence Therapeutics
SLN
$256M
$15.3M 0.82%
881,173
– –
TYRA icon
35
Tyra Biosciences
TYRA
$647M
$14.2M 0.76%
1,026,420
-1,593
-0.2% -$22.1K
CRNX icon
36
Crinetics Pharmaceuticals
CRNX
$3.21B
$14.1M 0.76%
397,483
-1,192,448
-75% -$42.4M
GPCR icon
37
Structure Therapeutics
GPCR
$1.11B
$12.9M 0.69%
+317,190
New +$12.9M
ARVN icon
38
Arvinas
ARVN
$553M
$11.7M 0.63%
285,331
– –
COGT icon
39
Cogent Biosciences
COGT
$1.81B
$11.7M 0.63%
1,995,267
+493,884
+33% +$2.9M
AGIO icon
40
Agios Pharmaceuticals
AGIO
$2.09B
$11.7M 0.62%
523,166
+231,164
+79% +$5.15M
APGE icon
41
Apogee Therapeutics
APGE
$2.23B
$11.2M 0.6%
400,000
– –
TRVI icon
42
Trevi Therapeutics
TRVI
$868M
$9.89M 0.53%
7,381,090
+500,000
+7% +$670K
THRX
43
DELISTED
Theseus Pharmaceuticals, Inc. Common Stock
THRX
$8.58M 0.46%
2,118,051
-130,143
-6% -$527K
NTLA icon
44
Intellia Therapeutics
NTLA
$1.26B
$6.21M 0.33%
203,684
– –
MRTX
45
DELISTED
Mirati Therapeutics, Inc. Common Stock
MRTX
$4.7M 0.25%
+80,000
New +$4.7M
BLUE
46
DELISTED
bluebird bio
BLUE
$2.36M 0.13%
85,495
– –
GRTS
47
DELISTED
Gritstone bio, Inc. Common Stock
GRTS
$2.1M 0.11%
1,030,878
-400,000
-28% -$816K
NAMSW icon
48
NewAmsterdam Pharma Company N.V. Warrant
NAMSW
$59.9M
$1.57M 0.08%
500,333
– –
ACRS icon
49
Aclaris Therapeutics
ACRS
$221M
$278K 0.01%
264,377
– –
ADCT icon
50
ADC Therapeutics
ADCT
$366M
– –
-1,647,030
Closed -$1.48M
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