FLSM

Frazier Life Sciences Management Portfolio holdings

AUM $2.5B

2025 Q2 2025 Q1 2024 Q4 2024 Q3 2024 Q2 2024 Q1 2023 Q4 2023 Q3 2023 Q2 2023 Q1 2022 Q4 2022 Q3 2022 Q2 2022 Q1

This Quarter Return

-4.79%

1 Year Return

+52.94%

3 Year Return

+530.54%

5 Year Return

–

10 Year Return

–

AUM

$1.06B

AUM Growth

+$1.06B (-9.7%)

Cap. Flow

-$30.5M

Cap. Flow % of AUM

-2.88%

Top 10 Holdings % Top 10 Hldgs %

68.2%

Holding

New

Increased

Reduced

Closed

Top Buys

1	HilleVax HLVX	$101M
2	KDNY Chinook Therapeutics, Inc. Common Stock KDNY	$15.4M
3	Krystal Biotech KRYS	$15M
4	Tarsus Pharmaceuticals TARS	$5.41M
5	CERE Cerevel Therapeutics Holdings, Inc. Common Stock CERE	$3.87M

Top Sells

1	SRRA Sierra Oncology, Inc. Common Stock SRRA	$80.9M
2	BCYC Bicycle Therapeutics BCYC	$26.5M
3	ISEE IVERIC bio, Inc. Common Stock ISEE	$21.7M
4	Vaxcyte PCVX	$11.4M
5	ALPN Alpine Immune Sciences, Inc. Common Stock ALPN	$10.2M

Sector Composition

Healthcare

98.6%

Communication Services

Advertising Agencies

Broadcasting

Electronic Gaming & Multimedia

Entertainment

Internet Content & Information

Publishing

Telecom Services

Consumer Discretionary

Apparel Manufacturing

Apparel Retail

Auto Manufacturers

Auto Parts

Auto & Truck Dealerships

Department Stores

Footwear & Accessories

Furnishings, Fixtures & Appliances

Gambling

Home Improvement Retail

Internet Retail

Leisure

Lodging

Luxury Goods

Packaging & Containers

Personal Services

Recreational Vehicles

Residential Construction

Resorts & Casinos

Restaurants

Specialty Retail

Textile Manufacturing

Travel Services

Consumer Staples

Beverages - Brewers

Beverages - Non-Alcoholic

Beverages - Wineries & Distilleries

Confectioners

Discount Stores

Education & Training Services

Farm Products

Food Distribution

Grocery Stores

Household & Personal Products

Packaged Foods

Tobacco

Energy

Oil & Gas Drilling

Oil & Gas Equipment & Services

Oil & Gas Exploration & Production

Oil & Gas Integrated

Oil & Gas Midstream

Oil & Gas Refining & Marketing

Thermal Coal

Uranium

Financials

Asset Management

Banks - Diversified

Banks - Regional

Capital Markets

Credit Services

Diversified Insurance

Financial Conglomerates

Financial Data & Stock Exchanges

Insurance Brokers

Life Insurance

Mortgage Finance

Property & Casualty Insurance

Reinsurance

Shell Companies

Specialty - Insurance

Healthcare

Biotechnology

Diagnostics & Research

Drug Manufacturers - General

Drug Manufacturers - Specialty & Generic

Healthcare Plans

Health Information Services

Medical Care Facilities

Medical Devices

Medical Distribution

Medical Instruments & Supplies

Pharmaceutical Retailers

Industrials

Aerospace & Defense

Airlines

Airports & Air Services

Building Products & Equipment

Business Equipment & Supplies

Conglomerates

Consulting Services

Electrical Equipment & Parts

Engineering & Construction

Farm & Heavy Construction Machinery

Industrial Distribution

Infrastructure Operations

Integrated Freight & Logistics

Marine Shipping

Metal Fabrication

Pollution & Treatment Controls

Railroads

Rental & Leasing Services

Security & Protection Services

Specialty Business Services

Specialty Industrial Machinery

Staffing & Employment Services

Tools & Accessories

Trucking

Waste Management

Materials

Agricultural Inputs

Aluminum

Building Materials

Chemicals

Coking Coal

Copper

Gold

Lumber & Wood Production

Other Industrial Metals & Mining

Other Precious Metals & Mining

Paper & Paper Products

Silver

Specialty Chemicals

Steel

Real Estate

Diversified REIT

Healthcare Facilities REIT

Hotel & Motel REIT

Industrial REIT

Mortgage REIT

Office REIT

Real Estate Development

Real Estate Diversified

Real Estate Services

Residential REIT

Retail REIT

Specialty REIT

Technology

Communication Equipment

Computer Hardware

Consumer Electronics

Electronic Components

Electronics & Computer Distribution

Information Technology Services

Scientific & Technical Instruments

Semiconductor Equipment & Materials

Semiconductors

Software - Application

Software - Infrastructure

Solar

Utilities

Diversified Utilities

Electric Utilities

Gas Utilities

Independent Power Producers

Renewable Electricity

Water Utilities

#	Name	Market Value	Portfolio Weight	Shares or Principal	Shares Change %	Capital Flow
26	AUTL 26 Autolus Therapeutics AUTL $383M	$10.6M	1%	3,746,857	–	–
27	27 Intellia Therapeutics NTLA $1.26B	$10.5M	1%	203,684	–	–
28	SLN 28 Silence Therapeutics SLN $237M	$10.4M	0.99%	881,173	–	–
29	29 Tyra Biosciences TYRA $657M	$9.83M	0.93%	1,375,065 +47,400	+4%	+$339K
30	30 Sutro Biopharma STRO $85.6M	$9.26M	0.87%	1,776,479	–	–
31	31 Aclaris Therapeutics ACRS $223M	$5.7M	0.54%	408,329	–	–
32	CERE 32 DELISTED Cerevel Therapeutics Holdings, Inc. Common Stock CERE	$5.35M	0.5%	202,260 +146,425	+262%	+$3.87M
33	33 Trevi Therapeutics TRVI $871M	$3.29M	0.31%	+1,171,627	New	+$3.29M
34	PRDS 34 DELISTED Pardes Biosciences, Inc. Common Stock PRDS	$2.6M	0.25%	845,636 -1,235,371	-59%	-$3.79M
35	35 Immunovant IMVT $2.91B	$2.28M	0.22%	585,759	–	–
36	36 ESSA Pharma EPIX $11.2M	$2.18M	0.21%	692,910	–	–
37	ISEE 37 DELISTED IVERIC bio, Inc. Common Stock ISEE	$1.64M	0.15%	170,000 -2,251,563	-93%	-$21.7M
38	MTEM 38 DELISTED Molecular Templates, Inc. MTEM	$1.25M	0.12%	1,374,047	–	–
39	EPZM 39 DELISTED Epizyme, Inc EPZM	$1.09M	0.1%	739,369	–	–
40	APTX 40 DELISTED Aptinyx Inc. Common Stock APTX	$1.05M	0.1%	1,883,244	–	–
41	NBRV 41 DELISTED Nabriva Therapeutics plc Ordinary Shares Ireland NBRV	$77K	0.01%	425,650	–	–
42	42 Scholar Rock SRRK $3.3B	–	–	-156,000	Closed	-$2.01M
43	BCYC 43 Bicycle Therapeutics BCYC $492M	–	–	-603,521	Closed	-$26.5M
44	AVDL 44 Avadel Pharmaceuticals AVDL $1.42B	–	–	-951,814	Closed	-$6.5M