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SPRB

Spruce Biosciences
SPRB

3 hedge funds and large institutions have $147K invested in Spruce Biosciences in 2025 Q2 according to their latest regulatory filings, with 0 funds opening new positions, 0 increasing their positions, 0 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

90% less funds holding

Funds holding: 31 → 3 (-28)

95% less capital invested

Capital invested by funds: $3.03M → $147K (-$2.88M)

100% less first-time investments, than exits

New positions opened: 0 | Existing positions closed: 28

Holders
3
Holders Change
-28
Holders Change %
-90.32%
% of All Funds
0.04%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
–
Increased
–
Reduced
–
Closed
28
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

No buyers this quarter

Top Sellers

Rank Fund Capital Flow
1
CG
Carlyle Group
District of Columbia
-$840K
2
RSCM
Rock Springs Capital Management
Maryland
-$757K
3
Vanguard Group
Vanguard Group
Pennsylvania
-$245K
4
ACM
ADAR1 Capital Management
Texas
-$117K
5
Renaissance Technologies
Renaissance Technologies
New York
-$111K
Name Holding Trade Value Shares
Change 		Change in
Stake
Acadian Asset Management
1
Acadian Asset Management
Massachusetts
$74K – – –
IC
2
Ikarian Capital
Texas
$72.5K – – –
CSC
3
Caldwell Sutter Capital
California
$73 – – –
CG
4
Carlyle Group
District of Columbia
– -$840K -38,620 Closed
RSCM
5
Rock Springs Capital Management
Maryland
– -$757K -34,788 Closed
Vanguard Group
6
Vanguard Group
Pennsylvania
– -$245K -11,251 Closed
ACM
7
ADAR1 Capital Management
Texas
– -$117K -5,383 Closed
Renaissance Technologies
8
Renaissance Technologies
New York
– -$111K -5,105 Closed
BFM
9
Boothbay Fund Management
New York
– -$83.8K -3,851 Closed
Geode Capital Management
10
Geode Capital Management
Massachusetts
– -$80.3K -3,689 Closed
BlackRock
11
BlackRock
New York
– -$36.2K -1,663 Closed
UBS Group
12
UBS Group
Switzerland
– -$33.8K -1,553 Closed
LPC
13
Lion Point Capital
New York
– -$21.8K -1,000 Closed
State Street
14
State Street
Massachusetts
– -$17.6K -809 Closed
TSS
15
Two Sigma Securities
New York
– -$13.8K -636 Closed
XT
16
XTX Topco
Cayman Islands
– -$12K -550 Closed
VF
17
Virtu Financial
New York
– -$11K -526 Closed
SC
18
Shay Capital
New York
– -$11.1K -508 Closed
Jane Street
19
Jane Street
New York
– -$10.9K -499 Closed
Northern Trust
20
Northern Trust
Illinois
– -$9.49K -436 Closed
Two Sigma Investments
21
Two Sigma Investments
New York
– -$5.96K -274 Closed
GSC
22
Ground Swell Capital
South Carolina
– -$5.02K -231 Closed
MG
23
Marex Group
– -$4.29K -197 Closed
Two Sigma Advisers
24
Two Sigma Advisers
New York
– -$3.54K -163 Closed
Citigroup
25
Citigroup
New York
– -$3.21K -148 Closed
1
2

SPRB Hedge Fund Activity: Q2 2025 in Review

3 of the 7,604 institutional investors tracked by Wall St. Rank reported a position in Spruce Biosciences (SPRB) for Q2 2025, worth a combined $147K — down 95% from $3.03M a quarter earlier.

Sellers outnumbered buyers: 28 funds closed out of SPRB and 0 opened new positions — a net loss of 28 holders — while 0 trimmed existing stakes and 0 added.

The largest seller was Carlyle Group, exiting entirely with an estimated $840K sold.

  • 3 institutional investors held Spruce Biosciences (SPRB) as of Q2 2025, down from 31 in Q1 2025.
  • Funds reported $147K of Spruce Biosciences stock for Q2 2025, down 95% quarter-over-quarter.
  • 0 funds opened new Spruce Biosciences positions in Q2 2025 and 28 closed out, a net change of -28 holders.
  • The largest Spruce Biosciences seller in Q2 2025 was Carlyle Group, an estimated $840K sold.

Based on aggregated 13F filings for Q2 2025.