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SPRB

Spruce Biosciences
SPRB

32 hedge funds and large institutions have $65.6M invested in Spruce Biosciences in 2025 Q4 according to their latest regulatory filings, with 25 funds opening new positions, 4 increasing their positions, 1 reducing their positions, and 2 closing their positions.

New
Increased
Maintained
Reduced
Closed

1,150% more first-time investments, than exits

New positions opened: 25 | Existing positions closed: 2

300% more repeat investments, than reductions

Existing positions increased: 4 | Existing positions reduced: 1

256% more funds holding

Funds holding: 9 → 32 (+23)

161% more capital invested

Capital invested by funds: $25.1M → $65.6M (+$40.5M)

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

451.36% less ownership

Funds ownership: 521.79% → 70.43% (-451%)

Holders
32
Holders Change
+23
Holders Change %
+255.56%
% of All Funds
0.39%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
25
Increased
4
Reduced
1
Closed
2
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
IC
Ikarian Capital
Texas
+$11.6M
2
Citadel Advisors
Citadel Advisors
Florida
+$7.5M
3
Wellington Management Group
Wellington Management Group
Massachusetts
+$6.32M
4
ACM
ADAR1 Capital Management
Texas
+$6.21M
5
Alyeska Investment Group
Alyeska Investment Group
Illinois
+$5.54M

Top Sellers

Rank Fund Capital Flow
1
CG
Carlyle Group
District of Columbia
-$306M
2
CCC
Cable Car Capital
California
-$239K
3
Osaic Holdings
Osaic Holdings
Arizona
-$931
Name Holding Trade Value Shares
Change 		Change in
Stake
IC
1
Ikarian Capital
Texas
$10.6M +$11.6M +108,024 +810%
SCM
2
Squadron Capital Management
Illinois
$6.1M +$7.5M +70,000 New
Citadel Advisors
3
Citadel Advisors
Florida
$6.1M +$7.5M +69,999 New
Wellington Management Group
4
Wellington Management Group
Massachusetts
$5.14M +$6.32M +58,949 New
ACM
5
ADAR1 Capital Management
Texas
$5.05M +$6.21M +58,000 New
Alyeska Investment Group
6
Alyeska Investment Group
Illinois
$4.5M +$5.54M +51,671 New
BFM
7
Boothbay Fund Management
New York
$4.18M +$5.14M +47,933 New
Balyasny Asset Management
8
Balyasny Asset Management
Illinois
$3.48M +$4.29M +40,000 New
CG
9
Carlyle Group
District of Columbia
$3.3M -$306M -2,857,898 -99%
ECM
10
ExodusPoint Capital Management
New York
$2.2M +$2.71M +25,271 New
SSA
11
Schonfeld Strategic Advisors
New York
$2.16M +$2.65M +24,767 New
QOP
12
Quinn Opportunity Partners
Virginia
$1.99M +$2.44M +22,810 New
CP
13
Caligan Partners
New York
$1.79M +$2.2M +20,514 New
SCM
14
Stonepine Capital Management
Oregon
$1.72M +$2.12M +19,742 New
Vanguard Group
15
Vanguard Group
Pennsylvania
$1.56M +$1.91M +17,873 New
BlackRock
16
BlackRock
New York
$1.48M +$1.81M +16,938 New
Geode Capital Management
17
Geode Capital Management
Massachusetts
$1.11M +$1.36M +12,732 New
SCM
18
Superstring Capital Management
New York
$1.06M +$1.3M +12,137 New
State Street
19
State Street
Massachusetts
$558K +$686K +6,400 New
UBS Group
20
UBS Group
Switzerland
$427K +$511K +4,770 +3,614%
RCAP
21
Resolute Capital Asset Partners
Colorado
$348K +$429K +4,000 New
SIA
22
SkyView Investment Advisors
New Jersey
$261K +$321K +3,000 New
Northern Trust
23
Northern Trust
Illinois
$211K +$259K +2,422 New
BNP Paribas Financial Markets
24
BNP Paribas Financial Markets
France
$174K +$214K +2,000 New
LPC
25
Lion Point Capital
New York
$87.1K – – –
1
2

SPRB Hedge Fund Activity: Q4 2025 in Review

32 of the 8,252 institutional investors tracked by Wall St. Rank reported a position in Spruce Biosciences (SPRB) for Q4 2025, worth a combined $65.6M — up 161% from $25.1M a quarter earlier.

Buyers outnumbered sellers: 25 funds opened new SPRB positions and 2 closed out — a net gain of 23 holders — while 4 added to existing stakes and 1 trimmed.

The largest buyer was Ikarian Capital, adding an estimated $11.6M. The largest seller was Carlyle Group, cutting an estimated $306M.

  • 32 institutional investors held Spruce Biosciences (SPRB) as of Q4 2025, up from 9 in Q3 2025.
  • Funds reported $65.6M of Spruce Biosciences stock for Q4 2025, up 161% quarter-over-quarter.
  • 25 funds opened new Spruce Biosciences positions in Q4 2025 and 2 closed out, a net change of +23 holders.
  • The largest Spruce Biosciences buyer in Q4 2025 was Ikarian Capital, an estimated $11.6M added.
  • The largest Spruce Biosciences seller in Q4 2025 was Carlyle Group, an estimated $306M sold.

Based on aggregated 13F filings for Q4 2025.