Spruce Biosciences
SPRB
64 hedge funds and large institutions have $108M invested in Spruce Biosciences in 2026 Q2 according to their latest regulatory filings, with 36 funds opening new positions, 16 increasing their positions, 3 reducing their positions, and 4 closing their positions.
800% more first-time investments, than exits
New positions opened: 36 | Existing positions closed: 4
433% more repeat investments, than reductions
Existing positions increased: 16 | Existing positions reduced: 3
124% more capital invested
Capital invested by funds: $48.3M → $108M (+$60M)
100% more funds holding
Funds holding: 32 → 64 (+32)
46% more ownership
Funds ownership: 26.88% → 72.88% (+46%)
0% more funds holding in top 10
Funds holding in top 10: 1 → 1 (0)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
ACM
AIGH Capital Management
Baltimore,
Maryland
|
+$14M |
| 2 |
O
OrbiMed
New York
|
+$11.2M |
| 3 |
BlackRock
New York
|
+$9.55M |
| 4 |
Vanguard Capital Management
Malvern,
Pennsylvania
|
+$5.65M |
| 5 |
CCC
Cable Car Capital
San Francisco,
California
|
+$3.35M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Wellington Management Group
Boston,
Massachusetts
|
-$3.19M |
| 2 |
Balyasny Asset Management
Chicago,
Illinois
|
-$1.56M |
| 3 |
Citadel Advisors
Miami,
Florida
|
-$1.01M |
| 4 |
SCM
Squadron Capital Management
Westmont,
Illinois
|
-$797K |
| 5 |
RCAP
Resolute Capital Asset Partners
Denver,
Colorado
|
-$261K |
SPRB Hedge Fund Activity: Q2 2026 in Review
64 of the 8,345 institutional investors tracked by Wall St. Rank reported a position in Spruce Biosciences (SPRB) for Q2 2026, worth a combined $108M — up 124% from $48.3M a quarter earlier.
Buyers outnumbered sellers: 36 funds opened new SPRB positions and 4 closed out — a net gain of 32 holders — while 16 added to existing stakes and 3 trimmed.
The largest buyer was AIGH Capital Management, opening a new position worth an estimated $14M. The largest seller was Wellington Management Group, exiting entirely with an estimated $3.19M sold.
- 64 institutional investors held Spruce Biosciences (SPRB) as of Q2 2026, up from 32 in Q1 2026.
- Funds reported $108M of Spruce Biosciences stock for Q2 2026, up 124% quarter-over-quarter.
- 36 funds opened new Spruce Biosciences positions in Q2 2026 and 4 closed out, a net change of +32 holders.
- The largest Spruce Biosciences buyer in Q2 2026 was AIGH Capital Management, an estimated $14M added.
- The largest Spruce Biosciences seller in Q2 2026 was Wellington Management Group, an estimated $3.19M sold.
Based on aggregated 13F filings for Q2 2026.