Vanguard Group
SPRB

Vanguard Group’s Spruce Biosciences SPRB Stock Holding History

Vanguard Group’s Portfolio SPRB Stock Details SPRB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		$1.56M Buy
+17,873
New +$1.91M ﹤0.01% 3641
2025
Q2 		– Sell
-11,251
Closed -$245K – 4345
2025
Q1 		$245K Hold
11,251
– – ﹤0.01% 4029
2024
Q4 		$354K Hold
11,251
– – ﹤0.01% 4020
2024
Q3 		$401K Sell
11,251
-261
-2% -$9.56K ﹤0.01% 4027
2024
Q2 		$447K Hold
11,512
– – ﹤0.01% 4039
2024
Q1 		$679K Buy
11,512
+547
+5% +$139K ﹤0.01% 3936
2023
Q4 		$2.41M Buy
10,965
+6,588
+151% +$761K ﹤0.01% 3537
2023
Q3 		$742K Buy
4,377
+884
+25% +$149K ﹤0.01% 3937
2023
Q2 		$563K Buy
3,493
+205
+6% +$34.3K ﹤0.01% 4086
2023
Q1 		$545K Buy
3,288
+1,620
+97% +$301K ﹤0.01% 4103
2022
Q4 		$137K Buy
1,668
+2
+0.1% +$167 ﹤0.01% 4356
2022
Q3 		$171K Buy
1,666
+119
+8% +$16.6K ﹤0.01% 4438
2022
Q2 		$202K Sell
1,547
-503
-25% -$64.4K ﹤0.01% 4468
2022
Q1 		$309K Sell
2,050
-2,912
-59% -$542K ﹤0.01% 4466
2021
Q4 		$1.66M Buy
4,962
+17
+0.3% +$5.06K ﹤0.01% 4108
2021
Q3 		$2.23M Buy
4,945
+18
+0.4% +$11.3K ﹤0.01% 4031
2021
Q2 		$4.14M Buy
4,927
+2,413
+96% +$2.58M ﹤0.01% 3686
2021
Q1 		$3.13M Buy
2,514
+60
+2% +$92.1K ﹤0.01% 3744
2020
Q4 		$4.47M Buy
+2,454
New +$4.07M ﹤0.01% 3414

Other funds holding SPRB

IC
Ikarian Capital Dallas, Texas $928M AUM 596.14% 1-Year Est. Return
SCM
Squadron Capital Management Westmont, Illinois $322M AUM
Citadel Advisors
Citadel Advisors Miami, Florida $875B AUM 40.91% 1-Year Est. Return
Wellington Management Group
Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return
ACM
ADAR1 Capital Management Austin, Texas $2.19B AUM 374.99% 1-Year Est. Return
Alyeska Investment Group
Alyeska Investment Group Chicago, Illinois $35.4B AUM 33.54% 1-Year Est. Return
BFM
Boothbay Fund Management New York $7.71B AUM 106.29% 1-Year Est. Return
Balyasny Asset Management
Balyasny Asset Management Chicago, Illinois $80.2B AUM 51.53% 1-Year Est. Return
CG
Carlyle Group Washington, District of Columbia $10B AUM 10.61% 1-Year Est. Return
ECM
ExodusPoint Capital Management New York $15.5B AUM 38.81% 1-Year Est. Return

Vanguard Group's SPRB Position: Q4 2025 in Review

Vanguard Group opened a new position in Spruce Biosciences (SPRB) in Q4 2025: 17,873 shares worth $1.56M. The stake represents ﹤0.01% of the portfolio and ranks #3641 among its holdings. This is a return to the name: Vanguard Group previously reported a position in SPRB as recently as Q1 2025.

Vanguard Group first reported a position in SPRB in Q4 2020 and has held it in 19 quarters since. The position peaked at $4.47M in Q4 2020. 32 funds tracked by Wall St. Rank hold SPRB as of Q4 2025.

  • Vanguard Group held 17,873 shares of Spruce Biosciences worth $1.56M as of Q4 2025.
  • Spruce Biosciences was a new Vanguard Group position in Q4 2025.
  • Spruce Biosciences made up ﹤0.01% of Vanguard Group's portfolio in Q4 2025, its #3641 holding.
  • Vanguard Group first reported a position in Spruce Biosciences in Q4 2020 and has held it in 19 quarters since.
  • Vanguard Group's Spruce Biosciences position peaked at $4.47M in Q4 2020.
  • 32 funds tracked by Wall St. Rank held Spruce Biosciences as of Q4 2025.

Based on Vanguard Group's 13F filing for Q4 2025, filed 29 Jan 2026.