SPRB

Spruce Biosciences, Inc. Common Stock
SPRB

Overview Fund Activity
Delisted

SPRB was delisted on the 28th of April, 2025.

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44 hedge funds and large institutions have $118M invested in Spruce Biosciences, Inc. Common Stock in 2021 Q3 according to their latest regulatory filings, with 7 funds opening new positions, 15 increasing their positions, 16 reducing their positions, and 4 closing their positions.

Holders
44
Holders Change
+3
Holders Change %
+7.32%
% of All Funds
0.77%
Holding in Top 10
1
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-66.67%
% of All Funds
0.02%
New
7
Increased
15
Reduced
16
Closed
4
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
SCV
1
Sands Capital Ventures
Virginia
$4.73M
2
DM
2
Deerfield Management
New York
$13.2M
3
Renaissance Technologies
3
Renaissance Technologies
New York
$204K
4
Jacobs Levy Equity Management
4
Jacobs Levy Equity Management
New Jersey
$146K
5
Millennium Management
5
Millennium Management
New York
$232K

Top Sellers

1
Sands Capital Management
1
Sands Capital Management
Virginia
$0
2
Adage Capital Partners
2
Adage Capital Partners
Massachusetts
$0
3
Fidelity Investments
3
Fidelity Investments
Massachusetts
$5.72M
4
CCM
4
CAAS Capital Management
New York
$166K
5
Morgan Stanley
5
Morgan Stanley
New York
$456K
Name Market Value Shares Shares
Change 		Shares
Change %
NHAS
1
Novo Holdings A/S
Denmark
$27.1M 4,514,336 – –
DM
2
Deerfield Management
New York
$13.2M 2,200,000 +153,042 +7%
OFM
3
Omega Fund Management
Massachusetts
$13M 2,161,022 – –
RVM
4
RiverVest Venture Management
Missouri
$12.9M 2,148,281 – –
Citadel Advisors
5
Citadel Advisors
Florida
$10.2M 1,701,076 -1,938 -0.1%
RSCM
6
Rock Springs Capital Management
Maryland
$9.72M 1,617,601 +12,600 +0.8%
ACM
7
Aisling Capital Management
New York
$7.25M 1,205,511 – –
Fidelity Investments
8
Fidelity Investments
Massachusetts
$5.72M 951,529 -234,144 -20%
SCV
9
Sands Capital Ventures
Virginia
$4.73M 787,007 +787,007 New
SCM
10
Sio Capital Management
New York
$3.62M 603,027 -44,212 -7%
BlackRock
11
BlackRock
New York
$2.53M 421,257 +1,468 +0.3%
Vanguard Group
12
Vanguard Group
Pennsylvania
$2.23M 370,850 +1,330 +0.4%
State Street
13
State Street
Massachusetts
$768K 127,817 +2,899 +2%
JPMorgan Chase & Co
14
JPMorgan Chase & Co
New York
$754K 125,459 -38,398 -23%
Geode Capital Management
15
Geode Capital Management
Massachusetts
$669K 111,417 -17,129 -13%
Morgan Stanley
16
Morgan Stanley
New York
$456K 75,911 -46,679 -38%
Northern Trust
17
Northern Trust
Illinois
$449K 74,670 -3,194 -4%
GPCM
18
Granite Point Capital Management
Massachusetts
$382K 63,614 -36,386 -36%
Millennium Management
19
Millennium Management
New York
$232K 38,622 +21,406 +124%
Renaissance Technologies
20
Renaissance Technologies
New York
$204K 34,000 +34,000 New
Two Sigma Investments
21
Two Sigma Investments
New York
$177K 29,392 +17,417 +145%
AA
22
ALPS Advisors
Colorado
$172K 28,648 -2,078 -7%
CCM
23
CAAS Capital Management
New York
$166K 27,546 -64,866 -70%
Bank of New York Mellon
24
Bank of New York Mellon
New York
$165K 27,448 +1,882 +7%
Nuveen Asset Management
25
Nuveen Asset Management
Illinois
$164K 23,018 -6,598 -22%
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