SPRB

Spruce Biosciences, Inc. Common Stock
SPRB

Overview Fund Activity
Delisted

SPRB was delisted on the 28th of April, 2025.

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41 hedge funds and large institutions have $225M invested in Spruce Biosciences, Inc. Common Stock in 2021 Q2 according to their latest regulatory filings, with 5 funds opening new positions, 17 increasing their positions, 12 reducing their positions, and 4 closing their positions.

Holders
41
Holders Change
+1
Holders Change %
+2.5%
% of All Funds
0.72%
Holding in Top 10
3
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-25%
% of All Funds
0.05%
New
5
Increased
17
Reduced
12
Closed
4
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
DM
1
Deerfield Management
New York
$22.9M
2
Vanguard Group
2
Vanguard Group
Pennsylvania
$4.14M
3
CCM
3
CAAS Capital Management
New York
$1.04M
4
Morgan Stanley
4
Morgan Stanley
New York
$1.38M
5
BlackRock
5
BlackRock
New York
$4.71M

Top Sellers

1
PHS
1
PFM Health Sciences
California
$0
2
NHAS
2
Novo Holdings A/S
Denmark
$50.6M
3
ACH
3
ArrowMark Colorado Holdings
Colorado
$0
4
SCM
4
Sio Capital Management
New York
$7.26M
5
Millennium Management
5
Millennium Management
New York
$193K
Name Market Value Shares Shares
Change 		Shares
Change %
NHAS
1
Novo Holdings A/S
Denmark
$50.6M 4,514,336 -475,000 -10%
OFM
2
Omega Fund Management
Massachusetts
$24.2M 2,161,022 – –
RVM
3
RiverVest Venture Management
Missouri
$24.1M 2,148,281 – –
DM
4
Deerfield Management
New York
$22.9M 2,046,958 +2,046,958 New
Citadel Advisors
5
Citadel Advisors
Florida
$19.1M 1,703,014 +209 +0%
RSCM
6
Rock Springs Capital Management
Maryland
$18M 1,605,001 +25,700 +2%
ACM
7
Aisling Capital Management
New York
$13.5M 1,205,511 – –
Fidelity Investments
8
Fidelity Investments
Massachusetts
$13.3M 1,185,673 -9,417 -0.8%
Sands Capital Management
9
Sands Capital Management
Virginia
$8.82M 787,007 – –
SCM
10
Sio Capital Management
New York
$7.26M 647,239 -165,645 -20%
BlackRock
11
BlackRock
New York
$4.71M 419,789 +74,483 +22%
Vanguard Group
12
Vanguard Group
Pennsylvania
$4.14M 369,520 +181,003 +96%
Adage Capital Partners
13
Adage Capital Partners
Massachusetts
$2.7M 240,511 -50,000 -17%
JPMorgan Chase & Co
14
JPMorgan Chase & Co
New York
$1.84M 163,857 -16,166 -9%
Geode Capital Management
15
Geode Capital Management
Massachusetts
$1.44M 128,546 +18,999 +17%
State Street
16
State Street
Massachusetts
$1.4M 124,918 +30,169 +32%
Morgan Stanley
17
Morgan Stanley
New York
$1.38M 122,590 +88,298 +257%
GPCM
18
Granite Point Capital Management
Massachusetts
$1.12M 100,000 – –
CCM
19
CAAS Capital Management
New York
$1.04M 92,412 +92,412 New
Northern Trust
20
Northern Trust
Illinois
$873K 77,864 +1,720 +2%
Charles Schwab
21
Charles Schwab
California
$485K 43,229 -909 -2%
AA
22
ALPS Advisors
Colorado
$344K 30,726 +30,726 New
Nuveen Asset Management
23
Nuveen Asset Management
Illinois
$332K 29,616 +18,194 +159%
Bank of New York Mellon
24
Bank of New York Mellon
New York
$286K 25,566 +6,386 +33%
Alyeska Investment Group
25
Alyeska Investment Group
Illinois
$218K 19,413 +19,413 New
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