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Rhythm Pharmaceuticals
RYTM

Overview Fund Activity

227 hedge funds and large institutions have $3.42B invested in Rhythm Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 45 funds opening new positions, 85 increasing their positions, 69 reducing their positions, and 20 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
227
Holders Change
+24
Holders Change %
+11.82%
% of All Funds
3.08%
Holding in Top 10
7
Holding in Top 10 Change
-4
Holding in Top 10 Change %
-36.36%
% of All Funds
0.1%
New
45
Increased
85
Reduced
69
Closed
20
Calls
$21.5M
Puts
$3.46M
Net Calls
+$18M
Net Calls Change
-$6.98M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$83.4M
2
Westfield Capital Management
Westfield Capital Management
Massachusetts
+$71M
3
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
+$27.2M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$23.9M
5
SL
Siren LLC
Connecticut
+$14.7M

Top Sellers

1
FLSM
Frazier Life Sciences Management
California
-$63.1M
2
PA
Perceptive Advisors
New York
-$60M
3
PCH
Polar Capital Holdings
United Kingdom
-$53M
4
Primecap Management
Primecap Management
California
-$41.5M
5
BBA
Baker Bros. Advisors
New York
-$25.4M
Name Holding Trade Value Shares
Change 		Shares
Change %
PCH
26
Polar Capital Holdings
United Kingdom
$26.5M -$53M -1,000,000 -67%
OM
27
Opaleye Management
Massachusetts
$26M -$530K -10,000 -2%
SI
28
Sofinnova Investments
California
$23.7M +$2.62M +49,411 +12%
Charles Schwab
29
Charles Schwab
California
$23.6M +$274K +5,179 +1%
Voloridge Investment Management
30
Voloridge Investment Management
Florida
$22.4M +$2.24M +42,331 +11%
O
31
OrbiMed
New York
$20.1M -$1.06M -20,000 -5%
Balyasny Asset Management
32
Balyasny Asset Management
Illinois
$18.8M +$11.5M +217,349 +157%
SCM
33
Silverarc Capital Management
Massachusetts
$17.9M +$3.37M +63,709 +23%
Franklin Resources
34
Franklin Resources
California
$17.3M +$3.07M +57,955 +22%
CS
35
Candriam SCA
Luxembourg
$15.4M -$2.17M -40,923 -12%
SL
36
Siren LLC
Connecticut
$14.7M +$14.7M +277,533 New
UBS Group
37
UBS Group
Switzerland
$14.4M +$945K +17,844 +7%
Invesco
38
Invesco
Georgia
$13.9M -$2.17M -40,944 -14%
Pictet Asset Management
39
Pictet Asset Management
Switzerland
$13.9M -$6.2M -116,003 -31%
Comerica Bank
40
Comerica Bank
Texas
$13M +$12.1M +227,641 +1,330%
Millennium Management
41
Millennium Management
New York
$11.5M +$10.7M +202,120 +1,325%
Qube Research & Technologies (QRT)
42
Qube Research & Technologies (QRT)
United Kingdom
$11.5M +$6.41M +120,958 +127%
CSS
43
Cubist Systematic Strategies
Connecticut
$9.21M +$9.21M +173,822 New
CAM
44
Cormorant Asset Management
Massachusetts
$7.95M -$13.2M -250,000 -63%
NL
45
Nuveen LLC
North Carolina
$7.8M +$7.8M +147,301 New
Bank of New York Mellon
46
Bank of New York Mellon
New York
$7.76M -$88K -1,661 -1%
JPMorgan Chase & Co
47
JPMorgan Chase & Co
New York
$7.61M -$6.41M -120,945 -46%
PAM
48
Panagora Asset Management
Massachusetts
$7.48M +$7.48M +141,162 New
SB
49
Samsara BioCapital
California
$7.32M -$1.83M -34,529 -20%
Lord, Abbett & Co
50
Lord, Abbett & Co
New Jersey
$7.17M -$1.34M -25,291 -16%
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