Opaleye Management’s Rhythm Pharmaceuticals RYTM Stock Holding History

Quarter	Market Value	Status	Shares	Shares Change %	Trade Value	Portfolio Weight	Portfolio Position
2025 Q2	$30M	Sell	475,000 -15,000	-3%	-$948K	6.07%	7
2025 Q1	$26M	Sell	490,000 -10,000	-2%	-$530K	5.78%	5
2024 Q4	$28M	Hold	500,000	–	–	4.9%	7
2024 Q3	$26.2M	Sell	500,000 -15,000	-3%	-$786K	4.37%	6
2024 Q2	$21.1M	Hold	515,000	–	–	4.83%	4
2024 Q1	$22.3M	Sell	515,000 -95,000	-16%	-$4.12M	4.86%	5
2023 Q4	$28M	Sell	610,000 -43,000	-7%	-$1.98M	7.46%	4
2023 Q3	$15M	Sell	653,000 -82,000	-11%	-$1.88M	4.87%	5
2023 Q2	$12.1M	Hold	735,000	–	–	2.9%	8
2023 Q1	$13.1M	Hold	735,000	–	–	3.93%	4
2022 Q4	$21.4M	Sell	735,000 -75,000	-9%	-$2.18M	7.44%	3
2022 Q3	$19.8M	Buy	810,000 +448,000	+124%	+$11M	8.2%	3
2022 Q2	$1.5M	Buy	+362,000	New	+$1.5M	0.68%	33
2021 Q1	–	Sell	-115,000	Closed	-$3.42M	–	65
2020 Q4	$3.42M	Buy	+115,000	New	+$3.42M	0.45%	45
2020 Q1	–	Sell	-110,500	Closed	-$2.54M	–	50
2019 Q4	$2.54M	Buy	+110,500	New	+$2.54M	0.5%	42
2018 Q1	–	Sell	-38,300	Closed	-$1.11M	–	44
2017 Q4	$1.11M	Buy	+38,300	New	+$1.11M	0.36%	32