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Pliant Therapeutics
PLRX

91 hedge funds and large institutions have $62.5M invested in Pliant Therapeutics in 2026 Q1 according to their latest regulatory filings, with 15 funds opening new positions, 26 increasing their positions, 26 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed

9% more capital invested

Capital invested by funds: $57.5M → $62.5M (+$4.94M)

4.26% more ownership

Funds ownership: 75.98% → 80.24% (+4.3%)

0% more repeat investments, than reductions

Existing positions increased: 26 | Existing positions reduced: 26

6% less first-time investments, than exits

New positions opened: 15 | Existing positions closed: 16

5% less funds holding

Funds holding: 96 → 91 (-5)

63% less call options, than puts

Call options by funds: $89K | Put options by funds: $238K

100% less funds holding in top 10

Funds holding in top 10: 1 → 0 (-1)

Holders
91
Holders Change
-5
Holders Change %
-5.21%
% of All Funds
1.12%
Holding in Top 10
–
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
–
New
15
Increased
26
Reduced
26
Closed
16
Calls
$89K
Puts
$238K
Net Calls
-$149K
Net Calls Change
-$133K

Top Buyers

1
ACM
ADAR1 Capital Management
Texas
+$3.17M
2
Two Sigma Investments
Two Sigma Investments
New York
+$1.64M
3
Renaissance Technologies
Renaissance Technologies
New York
+$1.02M
4
Millennium Management
Millennium Management
New York
+$974K
5
Citadel Advisors
Citadel Advisors
Florida
+$812K

Top Sellers

1
RG
Redmile Group
California
-$1.07M
2
CC
Centiva Capital
New York
-$716K
3
DekaBank Deutsche Girozentrale
DekaBank Deutsche Girozentrale
Germany
-$633K
4
WP
Woodline Partners
California
-$454K
5
Bank of America
Bank of America
North Carolina
-$453K
Name Holding Trade Value Shares
Change 		Change in
Stake
Morgan Stanley
26
Morgan Stanley
New York
$637K -$54.6K -43,223 -8%
XT
27
XTX Topco
Cayman Islands
$631K -$55.8K -44,178 -8%
DCM
28
DAFNA Capital Management
California
$614K +$615K +487,000 New
CC
29
Centiva Capital
New York
$545K -$716K -567,475 -57%
Geode Capital Management
30
Geode Capital Management
Massachusetts
$526K -$221K -175,422 -30%
LCM
31
Laurion Capital Management
New York
$520K +$196K +155,396 +60%
GCP
32
GSA Capital Partners
United Kingdom
$507K -$280K -221,606 -36%
Jane Street
33
Jane Street
New York
$450K -$375K -296,980 -45%
Bank of America
34
Bank of America
North Carolina
$444K -$453K -359,069 -50%
TC
35
Torno Capital
Massachusetts
$441K +$37.9K +30,000 +9%
VFT
36
Vanguard Fiduciary Trust
Pennsylvania
$428K +$429K +339,540 New
SEI Investments
37
SEI Investments
Pennsylvania
$375K – – –
ACH
38
ArrowMark Colorado Holdings
Colorado
$354K – – –
NCNMGF
39
Nano-Cap New Millennium Growth Fund
New York
$347K +$50.5K +40,000 +17%
State Street
40
State Street
Massachusetts
$319K – – –
RC
41
Rangeley Capital
Connecticut
$284K – – –
SCM
42
Stonepine Capital Management
Oregon
$283K -$6.82K -5,400 -2%
HWM
43
HighMark Wealth Management
Minnesota
$209K -$5.93K -4,700 -3%
Squarepoint
44
Squarepoint
New York
$206K +$81K +64,197 +65%
Northern Trust
45
Northern Trust
Illinois
$194K +$39K +30,903 +25%
VPM
46
Vanguard Portfolio Management
Pennsylvania
$194K +$194K +153,810 New
Invesco
47
Invesco
Georgia
$145K +$1.62K +1,284 +1%
Osaic Holdings
48
Osaic Holdings
Arizona
$145K -$59 -47 -0%
HWAM
49
Hennion & Walsh Asset Management
New Jersey
$134K -$8.43K -6,678 -6%
BDFN
50
Bond & Devick Financial Network
Minnesota
$126K – – –
1
2
3 4 5

PLRX Hedge Fund Activity: Q1 2026 in Review

91 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Pliant Therapeutics (PLRX) for Q1 2026, worth a combined $62.5M — up 8.6% from $57.5M a quarter earlier.

Sellers outnumbered buyers: 16 funds closed out of PLRX and 15 opened new positions — a net loss of 1 holder — while 26 trimmed existing stakes and 26 added.

The largest buyer was ADAR1 Capital Management, adding an estimated $3.17M. The largest seller was Redmile Group, cutting an estimated $1.07M.

  • 91 institutional investors held Pliant Therapeutics (PLRX) as of Q1 2026, down from 96 in Q4 2025.
  • Funds reported $62.5M of Pliant Therapeutics stock for Q1 2026, up 8.6% quarter-over-quarter.
  • 15 funds opened new Pliant Therapeutics positions in Q1 2026 and 16 closed out, a net change of -1 holder.
  • The largest Pliant Therapeutics buyer in Q1 2026 was ADAR1 Capital Management, an estimated $3.17M added.
  • The largest Pliant Therapeutics seller in Q1 2026 was Redmile Group, an estimated $1.07M sold.

Based on aggregated 13F filings for Q1 2026.