Two Sigma Investments
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Two Sigma Investments’s Pliant Therapeutics PLRX Stock Holding History

Two Sigma Investments’s Portfolio PLRX Stock Details PLRX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$2.84M Buy
2,253,138
+1,299,845
+136% +$1.64M ﹤0.01% 2479
2025
Q4 		$1.16M Buy
953,293
+170,038
+22% +$255K ﹤0.01% 2816
2025
Q3 		$1.16M Buy
783,255
+505,097
+182% +$771K ﹤0.01% 2480
2025
Q2 		$323K Buy
278,158
+2,871
+1% +$4.06K ﹤0.01% 2763
2025
Q1 		$372K Buy
275,287
+178,209
+184% +$1.08M ﹤0.01% 2634
2024
Q4 		$1.28M Sell
97,078
-38,044
-28% -$519K ﹤0.01% 2018
2024
Q3 		$1.51M Sell
135,122
-110,450
-45% -$1.38M ﹤0.01% 1849
2024
Q2 		$2.64M Buy
245,572
+138,548
+129% +$1.79M 0.01% 1366
2024
Q1 		$1.59M Buy
+107,024
New +$1.77M ﹤0.01% 1643
2023
Q4 		– Sell
-102,709
Closed -$1.78M – 3324
2023
Q3 		$1.78M Sell
102,709
-216,577
-68% -$3.75M ﹤0.01% 1485
2023
Q2 		$5.79M Sell
319,286
-97,364
-23% -$2.3M 0.01% 859
2023
Q1 		$11.1M Buy
416,650
+199,205
+92% +$5.67M 0.03% 554
2022
Q4 		$4.2M Sell
217,445
-30,562
-12% -$639K 0.01% 937
2022
Q3 		$5.18M Buy
248,007
+234,007
+1,671% +$4.48M 0.02% 736
2022
Q2 		$112K Sell
14,000
-111,278
-89% -$712K ﹤0.01% 2256
2022
Q1 		$878K Buy
125,278
+9,309
+8% +$95K ﹤0.01% 1766
2021
Q4 		$1.57M Buy
+115,969
New +$1.84M ﹤0.01% 2144

Other funds holding PLRX

TCM
Tang Capital Management San Diego, California $1.97B AUM 125.1% 1-Year Est. Return
Citadel Advisors
Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return
BOCH
Blue Owl Capital Holdings New York $372M AUM 78.25% 1-Year Est. Return
ACM
ADAR1 Capital Management Austin, Texas $1.7B AUM 340.85% 1-Year Est. Return
Acadian Asset Management
Acadian Asset Management Boston, Massachusetts $70.5B AUM 36% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
MAM
Monaco Asset Management Monaco $542M AUM 54.4% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
PM
Prosight Management Dallas, Texas $610M AUM 40.86% 1-Year Est. Return
WP
Woodline Partners San Francisco, California $26.4B AUM 44.85% 1-Year Est. Return

Two Sigma Investments's PLRX Position: Q1 2026 in Review

Two Sigma Investments increased its Pliant Therapeutics (PLRX) stake by 136% in Q1 2026, buying an estimated $1.64M and bringing the position to 2,253,138 shares worth $2.84M. The position accounts for ﹤0.01% of the portfolio, ranked #2479.

Two Sigma Investments first reported a position in PLRX in Q4 2021 and has held it in 17 quarters since. The position peaked at $11.1M in Q1 2023. 91 funds tracked by Wall St. Rank hold PLRX as of Q1 2026.

  • Two Sigma Investments held 2,253,138 shares of Pliant Therapeutics worth $2.84M as of Q1 2026.
  • Two Sigma Investments bought 1,299,845 Pliant Therapeutics shares in Q1 2026, an estimated $1.64M.
  • Pliant Therapeutics made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #2479 holding.
  • Two Sigma Investments first reported a position in Pliant Therapeutics in Q4 2021 and has held it in 17 quarters since.
  • Two Sigma Investments's Pliant Therapeutics position peaked at $11.1M in Q1 2023.
  • 91 funds tracked by Wall St. Rank held Pliant Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.