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Milestone Pharmaceuticals
MIST

86 hedge funds and large institutions have $36.4M invested in Milestone Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 21 funds opening new positions, 22 increasing their positions, 19 reducing their positions, and 14 closing their positions.

New
Increased
Maintained
Reduced
Closed

50% more first-time investments, than exits

New positions opened: 21 | Existing positions closed: 14

16% more repeat investments, than reductions

Existing positions increased: 22 | Existing positions reduced: 19

9% more funds holding

Funds holding: 79 → 86 (+7)

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

5.22% less ownership

Funds ownership: 31.11% → 25.89% (-5.2%)

32% less capital invested

Capital invested by funds: $53.6M → $36.4M (-$17.1M)

41% less call options, than puts

Call options by funds: $426K | Put options by funds: $718K

Holders
86
Holders Change
+7
Holders Change %
+8.86%
% of All Funds
1.06%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.02%
New
21
Increased
22
Reduced
19
Closed
14
Calls
$426K
Puts
$718K
Net Calls
-$292K
Net Calls Change
+$1.51M

Top Buyers

1
RI
RTW Investments
New York
+$6.7M
2
Goldman Sachs
Goldman Sachs
New York
+$3.5M
3
Millennium Management
Millennium Management
New York
+$2M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$1.49M
5
Two Sigma Investments
Two Sigma Investments
New York
+$1.41M

Top Sellers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$5.68M
2
Pathstone Holdings
Pathstone Holdings
New Jersey
-$1.75M
3
Jane Street
Jane Street
New York
-$1.63M
4
SCM
Stonepine Capital Management
Oregon
-$1.34M
5
Nomura Holdings
Nomura Holdings
Japan
-$455K
Name Holding Trade Value Shares
Change 		Change in
Stake
RI
1
RTW Investments
New York
$7.53M +$6.7M +3,824,899 +153%
PBM
2
Propel Bio Management
California
$5.08M – – –
Two Sigma Investments
3
Two Sigma Investments
New York
$2.76M +$1.41M +802,715 +53%
Goldman Sachs
4
Goldman Sachs
New York
$2.38M +$3.5M +2,000,025 New
Marshall Wace
5
Marshall Wace
United Kingdom
$2.31M +$504K +287,709 +17%
Millennium Management
6
Millennium Management
New York
$1.84M +$2M +1,141,690 +284%
SAM
7
Simplify Asset Management
Nevada
$1.79M – – –
Point72 Asset Management
8
Point72 Asset Management
Connecticut
$1.29M +$1.06M +603,328 +125%
Balyasny Asset Management
9
Balyasny Asset Management
Illinois
$1.01M +$1.49M +851,325 New
LPC
10
Lion Point Capital
New York
$976K +$114K +65,000 +9%
Toronto Dominion Bank
11
Toronto Dominion Bank
Ontario, Canada
$893K – – –
Morgan Stanley
12
Morgan Stanley
New York
$862K -$101K -57,734 -7%
BCM
13
Boxer Capital Management
California
$793K – – –
Ameriprise
14
Ameriprise
Minnesota
$793K +$1.17M +666,666 New
Susquehanna International Group
15
Susquehanna International Group
Pennsylvania
$618K -$218K -124,254 -19%
UBS Group
16
UBS Group
Switzerland
$589K +$5.32K +3,040 +0.6%
Squarepoint
17
Squarepoint
New York
$401K +$153K +87,481 +35%
SFCM
18
Seven Fleet Capital Management
California
$397K +$584K +333,333 New
ACA
19
Aptus Capital Advisors
Alabama
$333K +$29.9K +17,050 +6%
GWANC
20
Guardian Wealth Advisors (North Carolina)
North Carolina
$333K +$29.9K +17,050 +6%
Citadel Advisors
21
Citadel Advisors
Florida
$234K -$274K -156,536 -44%
LPL Financial
22
LPL Financial
California
$230K +$89.1K +50,910 +36%
BNP Paribas Financial Markets
23
BNP Paribas Financial Markets
France
$210K -$79.6K -45,447 -20%
BFM
24
Boothbay Fund Management
New York
$201K +$295K +168,675 New
Jane Street
25
Jane Street
New York
$190K -$1.63M -933,561 -85%
1
2 3 4

MIST Hedge Fund Activity: Q1 2026 in Review

86 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Milestone Pharmaceuticals (MIST) for Q1 2026, worth a combined $36.4M — down 32% from $53.6M a quarter earlier.

Buyers outnumbered sellers: 21 funds opened new MIST positions and 14 closed out — a net gain of 7 holders — while 22 added to existing stakes and 19 trimmed.

The largest buyer was RTW Investments, adding an estimated $6.7M. The largest seller was Adage Capital Partners, exiting entirely with an estimated $5.68M sold.

  • 86 institutional investors held Milestone Pharmaceuticals (MIST) as of Q1 2026, up from 79 in Q4 2025.
  • Funds reported $36.4M of Milestone Pharmaceuticals stock for Q1 2026, down 32% quarter-over-quarter.
  • 21 funds opened new Milestone Pharmaceuticals positions in Q1 2026 and 14 closed out, a net change of +7 holders.
  • The largest Milestone Pharmaceuticals buyer in Q1 2026 was RTW Investments, an estimated $6.7M added.
  • The largest Milestone Pharmaceuticals seller in Q1 2026 was Adage Capital Partners, an estimated $5.68M sold.

Based on aggregated 13F filings for Q1 2026.