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Milestone Pharmaceuticals
MIST

Overview Fund Activity

43 hedge funds and large institutions have $9.46M invested in Milestone Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 14 funds opening new positions, 6 increasing their positions, 11 reducing their positions, and 17 closing their positions.

Holders
43
Holders Change
-4
Holders Change %
-8.51%
% of All Funds
0.58%
Holding in Top 10
–
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
–
New
14
Increased
6
Reduced
11
Closed
17
Calls
$311K
Puts
$72K
Net Calls
+$239K
Net Calls Change
+$359K

Top Buyers

1
PBM
1
Propel Bio Management
California
$1.16M
2
SAM
2
Simplify Asset Management
Nevada
$680K
3
LPL Financial
3
LPL Financial
California
$89.2K
4
Walleye Capital
4
Walleye Capital
New York
$73.5K
5
Group One Trading
5
Group One Trading
Illinois
$111K

Top Sellers

1
BlackRock
1
BlackRock
New York
$0
2
O
2
OrbiMed
New York
$0
3
NCM
3
Nantahala Capital Management
Connecticut
$0
4
Goldman Sachs
4
Goldman Sachs
New York
$0
5
Millennium Management
5
Millennium Management
New York
$258K
Name Market Value Shares Shares
Change 		Shares
Change %
RI
1
RTW Investments
New York
$2.01M 2,506,102 – –
PBM
2
Propel Bio Management
California
$1.16M 1,451,557 +1,451,557 New
AFA
3
Alta Fundamental Advisers
New York
$1.14M 1,427,479 -1,231,110 -46%
BCM
4
BML Capital Management
Indiana
$909K 1,136,091 – –
Morgan Stanley
5
Morgan Stanley
New York
$775K 968,525 -320,616 -25%
SAM
6
Simplify Asset Management
Nevada
$680K 850,000 +850,000 New
Toronto Dominion Bank
7
Toronto Dominion Bank
Ontario, Canada
$600K 750,000 – –
LPC
8
Lion Point Capital
New York
$439K 548,806 -477,000 -47%
BL
9
Bleichroeder LP
New York
$400K 500,000 -826,085 -62%
Millennium Management
10
Millennium Management
New York
$258K 322,082 -2,381,177 -88%
SCM
11
Stonepine Capital Management
Oregon
$200K 250,000 -250,000 -50%
Group One Trading
12
Group One Trading
Illinois
$111K 138,360 +85,723 +163%
LPL Financial
13
LPL Financial
California
$89.2K 111,540 +111,540 New
UBS Group
14
UBS Group
Switzerland
$89.2K 111,523 +22,017 +25%
Walleye Capital
15
Walleye Capital
New York
$73.5K 91,920 +91,920 New
Two Sigma Advisers
16
Two Sigma Advisers
New York
$60.8K 76,000 +76,000 New
Susquehanna International Group
17
Susquehanna International Group
Pennsylvania
$49.7K 62,060 +28,968 +88%
Northern Trust
18
Northern Trust
Illinois
$42.4K 53,001 -5,107 -9%
XT
19
XTX Topco
Cayman Islands
$41.6K 52,004 +17,950 +53%
Simplex Trading
20
Simplex Trading
Illinois
$32K 40,636 +35,994 +775%
Dimensional Fund Advisors
21
Dimensional Fund Advisors
Texas
$31.7K 39,450 – –
Bank of America
22
Bank of America
North Carolina
$31.5K 39,396 +39,396 New
Raymond James Financial
23
Raymond James Financial
Florida
$26.6K 33,235 +33,235 New
BNP Paribas Financial Markets
24
BNP Paribas Financial Markets
France
$20.8K 26,023 -5,110 -16%
SIAG
25
Safeguard Investment Advisory Group
California
$20K 25,044 +25,044 New
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