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Milestone Pharmaceuticals
MIST

Overview Fund Activity

44 hedge funds and large institutions have $22.9M invested in Milestone Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 11 funds opening new positions, 10 increasing their positions, 9 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
44
Holders Change
+1
Holders Change %
+2.33%
% of All Funds
0.59%
Holding in Top 10
2
Holding in Top 10 Change
+2
Holding in Top 10 Change %
%
% of All Funds
0.03%
New
11
Increased
10
Reduced
9
Closed
10
Calls
$743K
Puts
$81K
Net Calls
+$662K
Net Calls Change
+$423K

Top Buyers

1
PBM
Propel Bio Management
California
$3.48M
2
UBS Group
UBS Group
Switzerland
$626K
3
SAM
Simplify Asset Management
Nevada
$1.92M
4
Goldman Sachs
Goldman Sachs
New York
$232K
5
VFA
Valeo Financial Advisors
Indiana
$254K

Top Sellers

1
Morgan Stanley
Morgan Stanley
New York
$1.59M
2
Millennium Management
Millennium Management
New York
$0
3
Group One Trading
Group One Trading
Illinois
$61.3K
4
SCM
Stonepine Capital Management
Oregon
$0
5
LPL Financial
LPL Financial
California
$21.4K
Name Holding Trade Value Shares
Change 		Shares
Change %
RI
1
RTW Investments
New York
$4.86M – – –
PBM
2
Propel Bio Management
California
$3.48M +$660K +340,000 +23%
AFA
3
Alta Fundamental Advisers
New York
$2.71M -$55.3K -28,502 -2%
BCM
4
BML Capital Management
Indiana
$2.2M – – –
SAM
5
Simplify Asset Management
Nevada
$1.92M +$272K +140,000 +16%
Morgan Stanley
6
Morgan Stanley
New York
$1.59M -$287K -148,104 -15%
Toronto Dominion Bank
7
Toronto Dominion Bank
Ontario, Canada
$1.46M – – –
LPC
8
Lion Point Capital
New York
$1.06M – – –
BL
9
Bleichroeder LP
New York
$970K – – –
UBS Group
10
UBS Group
Switzerland
$626K +$410K +211,125 +189%
XT
11
XTX Topco
Cayman Islands
$312K +$211K +108,959 +210%
VFA
12
Valeo Financial Advisors
Indiana
$254K +$215K +110,699 +553%
Goldman Sachs
13
Goldman Sachs
New York
$232K +$232K +119,449 New
CCAM
14
Cascades Capital Asset Management
North Carolina
$130K +$130K +67,135 New
Susquehanna International Group
15
Susquehanna International Group
Pennsylvania
$123K +$2.54K +1,309 +2%
Northern Trust
16
Northern Trust
Illinois
$103K – – –
Raymond James Financial
17
Raymond James Financial
Florida
$83.9K +$19.4K +10,000 +30%
Focus Partners Wealth
18
Focus Partners Wealth
Massachusetts
$69.8K +$69.8K +36,000 New
Royal Bank of Canada
19
Royal Bank of Canada
Ontario, Canada
$69K +$49.6K +25,600 +256%
Jane Street
20
Jane Street
New York
$62K +$62K +31,933 New
Group One Trading
21
Group One Trading
Illinois
$61.3K -$207K -106,744 -77%
SIAG
22
Safeguard Investment Advisory Group
California
$48.6K – – –
Creative Planning
23
Creative Planning
Kansas
$45.4K +$19.4K +10,000 +75%
SRL
24
Scientech Research LLC
New Jersey
$37K -$7.48K -3,854 -17%
National Bank of Canada
25
National Bank of Canada
Quebec, Canada
$36.1K – – –
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