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Milestone Pharmaceuticals

43 hedge funds and large institutions have $22.9M invested in Milestone Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 10 funds opening new positions, 10 increasing their positions, 9 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed

817% more call options, than puts

Call options by funds: $743K | Put options by funds: $81K

142% more capital invested

Capital invested by funds: $9.46M → $22.9M (+$13.5M)

11% more repeat investments, than reductions

Existing positions increased: 10 | Existing positions reduced: 9

0% more funds holding

Funds holding: 4343 (0)

0% more first-time investments, than exits

New positions opened: 10 | Existing positions closed: 10

0.06% less ownership

Funds ownership: 22.16%22.1% (-0.06%)

Holders
43
Holders Change
Holders Change %
0%
% of All Funds
0.57%
Holding in Top 10
2
Holding in Top 10 Change
+2
Holding in Top 10 Change %
% of All Funds
0.03%
New
10
Increased
10
Reduced
9
Closed
10
Calls
$743K
Puts
$81K
Net Calls
+$662K
Net Calls Change
+$423K
Name Holding Trade Value Shares
Change
Change in
Stake
RI
1
RTW Investments
New York
$4.86M
PBM
2
Propel Bio Management
California
$3.48M +$453K +340,000 +23%
AFA
3
Alta Fundamental Advisers
New York
$2.71M -$38K -28,502 -2%
BCM
4
BML Capital Management
Indiana
$2.2M
SAM
5
Simplify Asset Management
Nevada
$1.92M +$187K +140,000 +16%
Morgan Stanley
6
Morgan Stanley
New York
$1.59M -$197K -148,104 -15%
Toronto Dominion Bank
7
Toronto Dominion Bank
Ontario, Canada
$1.46M
LPC
8
Lion Point Capital
New York
$1.06M
BL
9
Bleichroeder LP
New York
$970K
UBS Group
10
UBS Group
Switzerland
$626K +$282K +211,125 +189%
XT
11
XTX Topco
Cayman Islands
$312K +$145K +108,959 +210%
VFA
12
Valeo Financial Advisors
Indiana
$254K +$148K +110,699 +553%
Goldman Sachs
13
Goldman Sachs
New York
$232K +$159K +119,449 New
CCAM
14
Cascades Capital Asset Management
North Carolina
$130K +$89.5K +67,135 New
Susquehanna International Group
15
Susquehanna International Group
Pennsylvania
$123K +$1.75K +1,309 +2%
Northern Trust
16
Northern Trust
Illinois
$103K
Raymond James Financial
17
Raymond James Financial
Florida
$83.9K +$13.3K +10,000 +30%
Focus Partners Wealth
18
Focus Partners Wealth
Massachusetts
$69.8K +$48K +36,000 New
Royal Bank of Canada
19
Royal Bank of Canada
Ontario, Canada
$69K +$34.1K +25,600 +256%
Jane Street
20
Jane Street
New York
$62K +$42.6K +31,933 New
Group One Trading
21
Group One Trading
Illinois
$61.3K -$142K -106,744 -77%
SIAG
22
Safeguard Investment Advisory Group
California
$48.6K
Creative Planning
23
Creative Planning
Kansas
$45.4K +$13.3K +10,000 +75%
SRL
24
Scientech Research LLC
New Jersey
$37K -$5.14K -3,854 -17%
National Bank of Canada
25
National Bank of Canada
Quebec, Canada
$36.1K

MIST Hedge Fund Activity: Q2 2025 in Review

43 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Milestone Pharmaceuticals (MIST) for Q2 2025, worth a combined $22.9M — up 142% from $9.46M a quarter earlier.

Fund positioning in MIST was balanced in Q2 2025: 10 funds opened new positions, 10 closed out, 10 added to existing stakes and 9 trimmed.

The largest buyer was Propel Bio Management, adding an estimated $453K. The largest seller was Millennium Management, exiting entirely with an estimated $258K sold.

  • 43 institutional investors held Milestone Pharmaceuticals (MIST) as of Q2 2025, unchanged from Q1 2025.
  • Funds reported $22.9M of Milestone Pharmaceuticals stock for Q2 2025, up 142% quarter-over-quarter.
  • 10 funds opened new Milestone Pharmaceuticals positions in Q2 2025 and 10 closed out, a net change of 0 holders.
  • The largest Milestone Pharmaceuticals buyer in Q2 2025 was Propel Bio Management, an estimated $453K added.
  • The largest Milestone Pharmaceuticals seller in Q2 2025 was Millennium Management, an estimated $258K sold.

Based on aggregated 13F filings for Q2 2025.