Two Sigma Investments’s Milestone Pharmaceuticals MIST Stock Holding History

Two Sigma Investments’s Portfolio MIST Stock Details MIST Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$2.76M	Buy	2,317,176 +802,715	+53%	+$1.41M	﹤0.01%	2502
2025 Q4	$3.06M	Buy	1,514,461 +847,910	+127%	+$1.83M	﹤0.01%	2130
2025 Q3	$1.33M	Buy	+666,551	New	+$1.17M	﹤0.01%	2396
2023 Q3	–	Sell	-52,186	Closed	-$149K	–	3110
2023 Q2	$149K	Buy	52,186 +16,879	+48%	+$63.7K	﹤0.01%	2697
2023 Q1	$139K	Sell	35,307 -159,036	-82%	-$581K	﹤0.01%	2626
2022 Q4	$770K	Buy	+194,343	New	+$1.02M	﹤0.01%	1836
2021 Q3	–	Sell	-16,235	Closed	-$89K	–	4517
2021 Q2	$89K	Sell	16,235 -38,578	-70%	-$219K	﹤0.01%	3915
2021 Q1	$317K	Sell	54,813 -2,598	-5%	-$19K	﹤0.01%	3288
2020 Q4	$385K	Buy	57,411 +37,509	+188%	+$251K	﹤0.01%	2679
2020 Q3	$146K	Buy	+19,902	New	+$143K	﹤0.01%	2889

Other funds holding MIST

RTW Investments New York $10B AUM 135.35% 1-Year Est. Return

PBM

Propel Bio Management Los Angeles, California $159M AUM 60.94% 1-Year Est. Return

Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return

Marshall Wace London, United Kingdom $100B AUM 35.1% 1-Year Est. Return

Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

SAM

Simplify Asset Management Las Vegas, Nevada $7.19B AUM 6.88% 1-Year Est. Return

Point72 Asset Management Stamford, Connecticut $78.1B AUM 55.25% 1-Year Est. Return

Balyasny Asset Management Chicago, Illinois $77.1B AUM 42.89% 1-Year Est. Return

LPC

Lion Point Capital New York $16.7M AUM 119.35% 1-Year Est. Return

Toronto Dominion Bank Toronto, Ontario, Ontario, Canada $69.7B AUM 40.86% 1-Year Est. Return

Two Sigma Investments's MIST Position: Q1 2026 in Review

Two Sigma Investments increased its Milestone Pharmaceuticals (MIST) stake by 53% in Q1 2026, buying an estimated $1.41M and bringing the position to 2,317,176 shares worth $2.76M. The position accounts for ﹤0.01% of the portfolio, ranked #2502.

Two Sigma Investments first reported a position in MIST in Q3 2020 and has held it in 10 quarters since. The position peaked at $3.06M in Q4 2025. 86 funds tracked by Wall St. Rank hold MIST as of Q1 2026.

Two Sigma Investments held 2,317,176 shares of Milestone Pharmaceuticals worth $2.76M as of Q1 2026.
Two Sigma Investments bought 802,715 Milestone Pharmaceuticals shares in Q1 2026, an estimated $1.41M.
Milestone Pharmaceuticals made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #2502 holding.
Two Sigma Investments first reported a position in Milestone Pharmaceuticals in Q3 2020 and has held it in 10 quarters since.
Two Sigma Investments's Milestone Pharmaceuticals position peaked at $3.06M in Q4 2025.
86 funds tracked by Wall St. Rank held Milestone Pharmaceuticals as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.