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Karyopharm Therapeutics
KPTI

Name Holding Trade Value Shares
Change 		Change in
Stake
BlackRock
1
BlackRock
New York
$105M +$12.7M +52,075 +12%
ACA
2
Avoro Capital Advisors
New York
$87.6M -$16.3M -66,667 -14%
PAI
3
Palo Alto Investors
California
$74.3M +$14.1M +57,780 +21%
State Street
4
State Street
Massachusetts
$69.9M +$3.1M +12,669 +4%
FCM
5
Frontier Capital Management
Massachusetts
$54.1M +$14.9M +60,886 +33%
Vanguard Group
6
Vanguard Group
Pennsylvania
$50.3M -$1.96M -7,996 -3%
Adage Capital Partners
7
Adage Capital Partners
Massachusetts
$46.9M -$584K -2,388 -1%
D.E. Shaw & Co
8
D.E. Shaw & Co
New York
$34.9M -$9.58M -39,169 -20%
Alkeon Capital Management
9
Alkeon Capital Management
New York
$31.6M +$1.63M +6,667 +5%
Wellington Management Group
10
Wellington Management Group
Massachusetts
$25.4M +$3.92M +16,013 +16%
EA
11
Emerald Advisers
Pennsylvania
$23.4M +$5.86M +23,937 +29%
RHJA
12
Rice Hall James & Associates
California
$21.2M +$11.3M +46,227 +91%
EMFAT
13
Emerald Mutual Fund Advisers Trust
Pennsylvania
$21.2M +$6.73M +27,504 +40%
T. Rowe Price Associates
14
T. Rowe Price Associates
Maryland
$21M -$8.55M -34,971 -27%
Two Sigma Investments
15
Two Sigma Investments
New York
$18.8M +$17.2M +70,127 +446%
Two Sigma Advisers
16
Two Sigma Advisers
New York
$17.3M +$4.61M +18,827 +31%
Geode Capital Management
17
Geode Capital Management
Massachusetts
$15.4M +$371K +1,517 +2%
Nuveen
18
Nuveen
North Carolina
$15.4M +$10.3M +41,966 +149%
Citadel Advisors
19
Citadel Advisors
Florida
$13.5M +$12.9M +52,554 +567%
HRCM
20
Hood River Capital Management
Florida
$13.4M -$1.49M -6,107 -9%
Goldman Sachs
21
Goldman Sachs
New York
$12.6M -$18.5M -75,694 -57%
Northern Trust
22
Northern Trust
Illinois
$12.4M -$829K -3,391 -6%
FFM
23
Fairmount Funds Management
Pennsylvania
$10.3M +$815K +3,333 +8%
Dimensional Fund Advisors
24
Dimensional Fund Advisors
Texas
$10.2M -$1.36M -5,550 -11%
AAM
25
AMI Asset Management
California
$8.95M +$10M +40,864 New
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