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Ionis Pharmaceuticals

339 hedge funds and large institutions have $5.01B invested in Ionis Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 54 funds opening new positions, 102 increasing their positions, 122 reducing their positions, and 61 closing their positions.

New
Increased
Maintained
Reduced
Closed

more funds holding in top 10

Funds holding in top 10:

more call options, than puts

Call options by funds: $ | Put options by funds: $

more ownership

Funds ownership:

less funds holding

Funds holding:

11% less capital invested

Capital invested by funds: $5.61B → $5.01B (-$606M)

11% less first-time investments, than exits

New positions opened: 54 | Existing positions closed: 61

16% less repeat investments, than reductions

Existing positions increased: 102 | Existing positions reduced: 122

Holders
339
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
6
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$24.8M
Puts
$18.8M
Net Calls
Net Calls Change

Top Buyers

1 +$79.4M
2 +$60.5M
3 +$57.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$39.6M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$27.9M
Name Holding Trade Value Shares
Change
Change in
Stake
TC
176
TwinBeech Capital
New York
$481K
Public Employees Retirement Association of Colorado
177
Public Employees Retirement Association of Colorado
Colorado
$470K
Envestnet Asset Management
178
Envestnet Asset Management
Illinois
$454K
Jones Financial Companies
179
Jones Financial Companies
Missouri
$428K
NSAM
180
North Star Asset Management
Wisconsin
$411K
SWP
181
Significant Wealth Partners
Illinois
$410K
WP
182
Westmount Partners
California
$391K
PHK
183
Point72 Hong Kong
Hong Kong
$388K
HKAM
184
Horizon Kinetics Asset Management
New York
$376K
XT
185
XTX Topco
Cayman Islands
$374K
Northwestern Mutual Wealth Management
186
Northwestern Mutual Wealth Management
Wisconsin
$373K
IIM
187
INTECH Investment Management
Florida
$368K
Brown Advisory
188
Brown Advisory
Maryland
$363K
SP
189
SIH Partners
Delaware
$362K
FC
190
FORA Capital
Florida
$349K
Twin Tree Management
191
Twin Tree Management
Texas
$343K
P
192
&Partners
Tennessee
$343K
PL
193
Plancorp LLC
Missouri
$336K
PNC Financial Services Group
194
PNC Financial Services Group
Pennsylvania
$331K
SCM
195
Suvretta Capital Management
New York
$326K
AGWCA
196
Annis Gardner Whiting Capital Advisors
Florida
$324K
AB
197
Amalgamated Bank
New York
$319K
HA
198
Harbor Advisors
Florida
$317K
Principal Financial Group
199
Principal Financial Group
Iowa
$315K
CM
200
Capula Management
Cayman Islands
$313K