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Ionis Pharmaceuticals

490 hedge funds and large institutions have $13B invested in Ionis Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 73 funds opening new positions, 177 increasing their positions, 155 reducing their positions, and 66 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding in top 10

Funds holding in top 10:

more funds holding

Funds holding:

0.75% less ownership

Funds ownership: 105.2%104.44% (-0.75%)

2% less call options, than puts

Call options by funds: $141M | Put options by funds: $144M

4% less capital invested

Capital invested by funds: $13.5B → $13B (-$517M)

Holders
490
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
14
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$141M
Puts
$144M
Net Calls
Net Calls Change

Top Buyers

1 +$255M
2 +$252M
3 +$212M
4
Millennium Management
Millennium Management
New York
+$75.6M
5
Artisan Partners
Artisan Partners
Wisconsin
+$69.2M

Top Sellers

1 -$235M
2 -$233M
3 -$94.1M
4
Nomura Holdings
Nomura Holdings
Japan
-$58M
5
TLP
Tri Locum Partners
New York
-$44.1M
Name Holding Trade Value Shares
Change
Change in
Stake
SG Americas Securities
151
SG Americas Securities
New York
$4.75M
Russell Investments Group
152
Russell Investments Group
United Kingdom
$4.72M
BCI
153
Brinker Capital Investments
Pennsylvania
$4.61M
PCMH
154
Polymer Capital Management (HK)
Hong Kong
$4.6M
Rafferty Asset Management
155
Rafferty Asset Management
New York
$4.53M
Zurich Cantonal Bank
156
Zurich Cantonal Bank
Switzerland
$4.52M
JFG
157
Jefferies Financial Group
New York
$4.44M
OCM
158
One Capital Management
California
$4.43M
FFL
159
Future Fund LLC
Illinois
$4.41M
PAM
160
Panagora Asset Management
Massachusetts
$4.31M
DA
161
DCF Advisers
Connecticut
$4.21M
QCM
162
Quantinno Capital Management
New York
$4.17M
FISPB
163
Fideuram - Intesa Sanpaolo Private Banking
$4.08M
State of New Jersey Common Pension Fund D
164
State of New Jersey Common Pension Fund D
New Jersey
$3.95M
Creative Planning
165
Creative Planning
Kansas
$3.92M
NWM
166
Nicola Wealth Management
British Columbia, Canada
$3.9M
Adage Capital Partners
167
Adage Capital Partners
Massachusetts
$3.75M
CC
168
Capital Counsel
New York
$3.72M
Tudor Investment Corp
169
Tudor Investment Corp
Connecticut
$3.62M
EFM
170
E Fund Management
China
$3.51M
Ohio Public Employees Retirement System (OPERS)
171
Ohio Public Employees Retirement System (OPERS)
Ohio
$3.46M
Ensign Peak Advisors
172
Ensign Peak Advisors
Utah
$3.45M
BAMCO Inc
173
BAMCO Inc
New York
$3.38M
WMA
174
West Michigan Advisors
Michigan
$3.35M
GC
175
Guggenheim Capital
Illinois
$3.31M