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Ionis Pharmaceuticals

490 hedge funds and large institutions have $13B invested in Ionis Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 73 funds opening new positions, 177 increasing their positions, 155 reducing their positions, and 66 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding in top 10

Funds holding in top 10:

more funds holding

Funds holding:

0.75% less ownership

Funds ownership: 105.2%104.44% (-0.75%)

2% less call options, than puts

Call options by funds: $141M | Put options by funds: $144M

4% less capital invested

Capital invested by funds: $13.5B → $13B (-$517M)

Holders
490
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
14
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$141M
Puts
$144M
Net Calls
Net Calls Change

Top Buyers

1 +$255M
2 +$252M
3 +$212M
4
Millennium Management
Millennium Management
New York
+$75.6M
5
Artisan Partners
Artisan Partners
Wisconsin
+$69.2M

Top Sellers

1 -$235M
2 -$233M
3 -$94.1M
4
Nomura Holdings
Nomura Holdings
Japan
-$58M
5
TLP
Tri Locum Partners
New York
-$44.1M
Name Holding Trade Value Shares
Change
Change in
Stake
SEI Investments
101
SEI Investments
Pennsylvania
$11.8M
CP
102
CenterBook Partners
Connecticut
$11.3M
Manulife (Manufacturers Life Insurance)
103
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$11.2M
ACM
104
Aquatic Capital Management
Illinois
$11.1M
Citigroup
105
Citigroup
New York
$11M
AGP
106
Artia Global Partners
Florida
$10.8M
Capital Fund Management (CFM)
107
Capital Fund Management (CFM)
France
$10.7M
Fisher Asset Management
108
Fisher Asset Management
Washington
$10.6M
VAM
109
Vanguard Asset Management
$10.3M
EDRH
110
Edmond de Rothschild Holding
Switzerland
$10.3M
State Board of Administration of Florida Retirement System
111
State Board of Administration of Florida Retirement System
Florida
$10.2M
EGM
112
Engineers Gate Manager
New York
$10M
B
113
Braidwell
Connecticut
$9.83M
IC
114
Ikarian Capital
Texas
$9.54M
HP
115
HealthInvest Partners
Sweden
$9.4M
IHAM
116
Integral Health Asset Management
New York
$9.39M
GLA
117
Great Lakes Advisors
Illinois
$8.93M
AG
118
Algert Global
California
$8.75M
SAM
119
SEB Asset Management
$8.59M
Nomura Holdings
120
Nomura Holdings
Japan
$8.57M
Aberdeen Group
121
Aberdeen Group
United Kingdom
$8.55M
KCM
122
Kennedy Capital Management
Missouri
$8.4M
EAM
123
Exome Asset Management
New York
$8.26M
Victory Capital Management
124
Victory Capital Management
Texas
$8.17M
WG
125
Winton Group
United Kingdom
$8M