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Ionis Pharmaceuticals

490 hedge funds and large institutions have $13B invested in Ionis Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 73 funds opening new positions, 177 increasing their positions, 155 reducing their positions, and 66 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding in top 10

Funds holding in top 10:

more funds holding

Funds holding:

0.75% less ownership

Funds ownership: 105.2%104.44% (-0.75%)

2% less call options, than puts

Call options by funds: $141M | Put options by funds: $144M

4% less capital invested

Capital invested by funds: $13.5B → $13B (-$517M)

Holders
490
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
14
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$141M
Puts
$144M
Net Calls
Net Calls Change

Top Buyers

1 +$255M
2 +$252M
3 +$212M
4
Millennium Management
Millennium Management
New York
+$75.6M
5
Artisan Partners
Artisan Partners
Wisconsin
+$69.2M

Top Sellers

1 -$235M
2 -$233M
3 -$94.1M
4
Nomura Holdings
Nomura Holdings
Japan
-$58M
5
TLP
Tri Locum Partners
New York
-$44.1M
Name Holding Trade Value Shares
Change
Change in
Stake
MWM
476
Mascoma Wealth Management
New Hampshire
$1.05K
RIL
477
Rothschild Investment LLC
Illinois
$976
CA
478
Clearstead Advisors
Ohio
$902
CPG
479
Cornerstone Planning Group
New Jersey
$753
EP
480
Essential Partners
California
$526
Kayne Anderson Rudnick Investment Management
481
Kayne Anderson Rudnick Investment Management
California
$526
TWD
482
True Wealth Design
Ohio
$526
ACA
483
American Capital Advisory
Idaho
$526
CIAM
484
Caitong International Asset Management
Hong Kong
$526
HFS
485
Hughes Financial Services
Virginia
$451
MCM
486
Manchester Capital Management
Vermont
$376
DF
487
Dunhill Financial
United Kingdom
$201
3FI
488
3 Factor Indexing
California
$151
Nisa Investment Advisors
489
Nisa Investment Advisors
Missouri
$75
TC
490
Truvestments Capital
Florida
$56
Two Sigma Advisers
491
Two Sigma Advisers
New York
TLP
492
Tri Locum Partners
New York
Norges Bank
493
Norges Bank
Norway
Balyasny Asset Management
494
Balyasny Asset Management
Illinois
Skandinaviska Enskilda Banken (SEB)
495
Skandinaviska Enskilda Banken (SEB)
Sweden
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
496
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
Simplex Trading
497
Simplex Trading
Illinois
BA
498
Bridgewater Associates
Connecticut
BAMF
499
BI Asset Management Fondsmaeglerselskab
Denmark
PP
500
PDT Partners
New York